The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Birth Weight

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Birth Weight


Psychiatry related information on Birth Weight


High impact information on Birth Weight


Chemical compound and disease context of Birth Weight

  • Women who had positive assays for cocaine, as compared with nonusers, had infants with a 93-g decrease in birth weight (P = 0.07), a 0.7-cm decrement in length (P = 0.01), and a 0.43-cm-smaller head circumference (P = 0.01) [16].
  • Exposing pregnant rats to carbon monoxide (150 parts per million) produced only minor reductions in the birth weights of the pups and gave no evidence of overt teratogenesis [17].
  • Prednisone therapy and birth weight [18].
  • In contrast to previous reports, the HbA1c values did not predict abnormal maternal glucose tolerance or infant birth weight [19].
  • RESULTS--The three groups of patients were comparable in birth weight, gestational age, antenatal administration of betamethasone, and other perinatal characteristics [20].
  • The biological mechanism behind this association may involve insulin-like growth factor I (IGF-I), which is associated with high birth weight [21].

Biological context of Birth Weight


Anatomical context of Birth Weight


Gene context of Birth Weight

  • OBJECTIVE: To investigate whether the association between maternal cigarette smoking and infant birth weight differs by polymorphisms of 2 maternal metabolic genes: CYP1A1 and GSTT1 [22].
  • In preeclamptic patients, a positive correlation between birth weight and PAI-2 values was observed (r = .64, P less than .05), whereas birth weight was inversely correlated with both PAI-1 levels and total PAI activity (r = -.6, P less than .005 and r = -.76, P less than .005 respectively) [31].
  • These data show that the biological function of imprinting Igf2r is to increase birth weight and they also establish Igf2r as the Tme gene [32].
  • Here we show that administration of carbenoxolone, an inhibitor of placental 11 beta-HSD 2, to pregnant rats, leads to a significant reduction in average birth weight (20% fall) [33].
  • IGF-II was weakly related to ponderal index (r = 0.18; P < 0.05) and placental weight (r = 0.18; P < 0.05), and the molar ratio of IGF-II to IGF2R was also related to birth weight (r = 0.15; P < 0.05) [34].

Analytical, diagnostic and therapeutic context of Birth Weight


  1. Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants. Schmidt, B., Davis, P., Moddemann, D., Ohlsson, A., Roberts, R.S., Saigal, S., Solimano, A., Vincer, M., Wright, L.L. N. Engl. J. Med. (2001) [Pubmed]
  2. Toxicity of mild prenatal carbon monoxide exposure. Fechter, L.D., Annau, Z. Science (1977) [Pubmed]
  3. Prenatal exposure to prednisone in humans and animals retards intrauterine growth. Reinisch, J.M., Simon, N.G., Karow, W.G., Gandelman, R. Science (1978) [Pubmed]
  4. Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects. Mitchell, S.M., Weedon, M.N., Owen, K.R., Shields, B., Wilkins-Wall, B., Walker, M., McCarthy, M.I., Frayling, T.M., Hattersley, A.T. Diabetes (2003) [Pubmed]
  5. Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene. Weedon, M.N., Frayling, T.M., Shields, B., Knight, B., Turner, T., Metcalf, B.S., Voss, L., Wilkin, T.J., McCarthy, A., Ben-Shlomo, Y., Davey Smith, G., Ring, S., Jones, R., Golding, J., Byberg, L., Mann, V., Axelsson, T., Syvänen, A.C., Leon, D., Hattersley, A.T. Diabetes (2005) [Pubmed]
  6. Is glutamate decarboxylase 2 (GAD2) a genetic link between low birth weight and subsequent development of obesity in children? Meyre, D., Boutin, P., Tounian, A., Deweirder, M., Aout, M., Jouret, B., Heude, B., Weill, J., Tauber, M., Tounian, P., Froguel, P. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  7. Nicotine patches for pregnant smokers: a randomized controlled study. Wisborg, K., Henriksen, T.B., Jespersen, L.B., Secher, N.J. Obstetrics and gynecology. (2000) [Pubmed]
  8. Is an exaggerated postprandial triglyceride response associated with the component features of the insulin resistance syndrome? Byrne, C.D., Wareham, N.J., Phillips, D.I., Hales, C.N., Martensz, N.D. Diabet. Med. (1997) [Pubmed]
  9. Results of 313 consecutive live births of infants delivered to patients in the New York City Methadone Maintenance Treatment Program. Newman, R.G., Bashkow, S., Calko, D. Am. J. Obstet. Gynecol. (1975) [Pubmed]
  10. Differential effects of prenatal stress in two inbred strains of rats. Stöhr, T., Schulte Wermeling, D., Szuran, T., Pliska, V., Domeney, A., Welzl, H., Weiner, I., Feldon, J. Pharmacol. Biochem. Behav. (1998) [Pubmed]
  11. Fluconazole prophylaxis against fungal colonization and infection in preterm infants. Kaufman, D., Boyle, R., Hazen, K.C., Patrie, J.T., Robinson, M., Donowitz, L.G. N. Engl. J. Med. (2001) [Pubmed]
  12. Vitamin A supplementation for extremely-low-birth-weight infants. National Institute of Child Health and Human Development Neonatal Research Network. Tyson, J.E., Wright, L.L., Oh, W., Kennedy, K.A., Mele, L., Ehrenkranz, R.A., Stoll, B.J., Lemons, J.A., Stevenson, D.K., Bauer, C.R., Korones, S.B., Fanaroff, A.A. N. Engl. J. Med. (1999) [Pubmed]
  13. Mutations in the glucokinase gene of the fetus result in reduced birth weight. Hattersley, A.T., Beards, F., Ballantyne, E., Appleton, M., Harvey, R., Ellard, S. Nat. Genet. (1998) [Pubmed]
  14. Effects of thyroxine supplementation on neurologic development in infants born at less than 30 weeks' gestation. van Wassenaer, A.G., Kok, J.H., de Vijlder, J.J., Briët, J.M., Smit, B.J., Tamminga, P., van Baar, A., Dekker, F.W., Vulsma, T. N. Engl. J. Med. (1997) [Pubmed]
  15. The effect of epoetin beta (recombinant human erythropoietin) on the need for transfusion in very-low-birth-weight infants. European Multicentre Erythropoietin Study Group. Maier, R.F., Obladen, M., Scigalla, P., Linderkamp, O., Duc, G., Hieronimi, G., Halliday, H.L., Versmold, H.T., Moriette, G., Jorch, G. N. Engl. J. Med. (1994) [Pubmed]
  16. Effects of maternal marijuana and cocaine use on fetal growth. Zuckerman, B., Frank, D.A., Hingson, R., Amaro, H., Levenson, S.M., Kayne, H., Parker, S., Vinci, R., Aboagye, K., Fried, L.E. N. Engl. J. Med. (1989) [Pubmed]
  17. Prenatal exposure to carbon monoxide: learning and memory deficits. Mactutus, C.F., Fechter, L.D. Science (1984) [Pubmed]
  18. Prednisone therapy and birth weight. Jefferies, W.M. Science (1979) [Pubmed]
  19. Hemoglobin A1c in normal and diabetic pregnancy. Miller, J.M., Crenshaw, M.C., Welt, S.I. JAMA (1979) [Pubmed]
  20. Early ibuprofen administration to prevent patent ductus arteriosus in premature newborn infants. Varvarigou, A., Bardin, C.L., Beharry, K., Chemtob, S., Papageorgiou, A., Aranda, J.V. JAMA (1996) [Pubmed]
  21. The epidemiology of childhood leukemia with a focus on birth weight and diet. Tower, R.L., Spector, L.G. Crit. Rev. Clin. Lab. Sci (2007) [Pubmed]
  22. Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight. Wang, X., Zuckerman, B., Pearson, C., Kaufman, G., Chen, C., Wang, G., Niu, T., Wise, P.H., Bauchner, H., Xu, X. JAMA (2002) [Pubmed]
  23. Glucose-6-phosphate dehydrogenase deficiency, the UDP-glucuronosyl transferase 1A1 gene, and neonatal hyperbilirubinemia. Huang, C.S., Chang, P.F., Huang, M.J., Chen, E.S., Chen, W.C. Gastroenterology (2002) [Pubmed]
  24. Running in pregnancy transiently increases postnatal hippocampal neurogenesis in the offspring. Bick-Sander, A., Steiner, B., Wolf, S.A., Babu, H., Kempermann, G. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  25. Insulin effect during embryogenesis determines fetal growth: a possible molecular link between birth weight and susceptibility to type 2 diabetes. Terauchi, Y., Kubota, N., Tamemoto, H., Sakura, H., Nagai, R., Akanuma, Y., Kimura, S., Kadowaki, T. Diabetes (2000) [Pubmed]
  26. Insulin resistance syndrome in 8-year-old Indian children: small at birth, big at 8 years, or both? Bavdekar, A., Yajnik, C.S., Fall, C.H., Bapat, S., Pandit, A.N., Deshpande, V., Bhave, S., Kellingray, S.D., Joglekar, C. Diabetes (1999) [Pubmed]
  27. Fetal effects of regular salicylate ingestion in pregnancy. Turner, G., Collins, E. Lancet (1975) [Pubmed]
  28. Associations between prenatal and postnatal growth and adult body size and composition. Li, H., Stein, A.D., Barnhart, H.X., Ramakrishnan, U., Martorell, R. Am. J. Clin. Nutr. (2003) [Pubmed]
  29. Type 2 11 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid and activity in human placenta and fetal membranes: its relationship to birth weight and putative role in fetal adrenal steroidogenesis. Stewart, P.M., Rogerson, F.M., Mason, J.I. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  30. Variability of the insulin receptor substrate-1, hepatocyte nuclear factor-1alpha (HNF-1alpha), HNF-4alpha, and HNF-6 genes and size at birth in a population-based sample of young Danish subjects. Rasmussen, S.K., Urhammer, S.A., Hansen, T., Almind, K., Møller, A.M., Borch-Johnsen, K., Pedersen, O. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  31. Changes in the plasma levels of type 1 and type 2 plasminogen activator inhibitors in normal pregnancy and in patients with severe preeclampsia. Estellés, A., Gilabert, J., Aznar, J., Loskutoff, D.J., Schleef, R.R. Blood (1989) [Pubmed]
  32. Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice. Wutz, A., Theussl, H.C., Dausman, J., Jaenisch, R., Barlow, D.P., Wagner, E.F. Development (2001) [Pubmed]
  33. Prenatal glucocorticoid exposure leads to offspring hyperglycaemia in the rat: studies with the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone. Lindsay, R.S., Lindsay, R.M., Waddell, B.J., Seckl, J.R. Diabetologia (1996) [Pubmed]
  34. Size at birth and cord blood levels of insulin, insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-1 (IGFBP-1), IGFBP-3, and the soluble IGF-II/mannose-6-phosphate receptor in term human infants. The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Ong, K., Kratzsch, J., Kiess, W., Costello, M., Scott, C., Dunger, D. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  35. The association between prenatal care and birth weight among women exposed to cocaine in New York City. Racine, A., Joyce, T., Anderson, R. JAMA (1993) [Pubmed]
  36. The Gly972Arg variant in insulin receptor substrate-1 is not associated with birth weight in contemporary English children. The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Mason, S., Ong, K.K., Pembrey, M.E., Woods, K.A., Dunger, D.B. Diabetologia (2000) [Pubmed]
  37. Smallness for gestational age is associated with persistent change in insulin-like growth factor I (IGF-I) and the ratio of IGF-I/IGF-binding protein-3 in adulthood. Verkauskiene, R., Jaquet, D., Deghmoun, S., Chevenne, D., Czernichow, P., Lévy-Marchal, C. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  38. Folic acid: influence on the outcome of pregnancy. Scholl, T.O., Johnson, W.G. Am. J. Clin. Nutr. (2000) [Pubmed]
  39. Opposing influences of prenatal and postnatal weight gain on adrenarche in normal boys and girls. Ong, K.K., Potau, N., Petry, C.J., Jones, R., Ness, A.R., Honour, J.W., de Zegher, F., Ibáñez, L., Dunger, D.B. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
WikiGenes - Universities