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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Boschero, A.C. et al.

Boschero, Stoppiglia, Collares-Buzato, Bosqueiro, Delghingaro-Augusto, Leite, Carvalho, Netto, Carneiro,

Expression of a thioredoxin peroxidase in insulin-producing cells.

The presence of thioredoxin peroxidase (TPx), also known as thiol specific antioxidant (TSA), was investigated in neonatal and adult rat islets, and in the beta-cell line HIT-T15. Western blotting of extracts from neonatal and adult pancreatic islets and from the tumoral cell line HIT-T15 revealed the presence of a 25 kDa protein that comigrated with purified yeast TPx. Endocrine pancreatic TPx accounted for approximately 0.01% of the total protein content. Treatment with H2O2 for 3 h increased the expression of TPx in HIT-T15 cells. The distribution of TPx throughout the islet cells was confirmed by immunocytochemistry. Since pancreatic beta-cells possess a weak antioxidant enzyme defense system, especially with regard to hydrogen peroxidase-decomposing enzymes, the presence of a TPx analog in islets suggests that this enzyme may play a role in protecting pancreatic cells against reactive oxygen species.[1]

References

Expression of a thioredoxin peroxidase in insulin-producing cells. Boschero, A.C., Stoppiglia, L.F., Collares-Buzato, C.B., Bosqueiro, J.R., Delghingaro-Augusto, V., Leite, A., Carvalho, C.P., Netto, L.E., Carneiro, E.M. Diabetes Metab. (2002) [Pubmed]

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