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Gene Review

Prdx2  -  peroxiredoxin 2

Rattus norvegicus

Synonyms: Peroxiredoxin-2, TSA, Tdpx1, Thiol-specific antioxidant protein, Thioredoxin peroxidase 1, ...
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High impact information on Prdx2


Anatomical context of Prdx2

  • The distribution of TPx throughout the islet cells was confirmed by immunocytochemistry [6].
  • Since pancreatic beta-cells possess a weak antioxidant enzyme defense system, especially with regard to hydrogen peroxidase-decomposing enzymes, the presence of a TPx analog in islets suggests that this enzyme may play a role in protecting pancreatic cells against reactive oxygen species [6].

Associations of Prdx2 with chemical compounds

  • A comparison was made of succinyladenylate lyase (SAMP lyase), total serum sialic (TSA), and lipid soluble serum sialic acid (LSA) as early markers of malignancy in three experimentally induced rat tumor models [7].

Analytical, diagnostic and therapeutic context of Prdx2


  1. Identification of a 28 kDa secretory protein from rat olfactory epithelium as a thiol-specific antioxidant. Peshenko, I.V., Novoselov, V.I., Evdokimov, V.A., Nikolaev, Y.V., Kamzalov, S.S., Shuvaeva, T.M., Lipkin, V.M., Fesenko, E.E. Free Radic. Biol. Med. (1998) [Pubmed]
  2. Genomic analysis of the rat lung following elemental mercury vapor exposure. Liu, J., Lei, D., Waalkes, M.P., Beliles, R.P., Morgan, D.L. Toxicol. Sci. (2003) [Pubmed]
  3. A comparative proteomic analysis of the rat brain during rebound hyperphagia induced by space-restriction. Ishihara, K., Nakata, K., Yamagishi, N., Iwasaki, S., Kiriike, N., Hatayama, T. Mol. Cell. Biochem. (2005) [Pubmed]
  4. Sialic acid is a marker of lung injury following lower extremities ischemia/reperfusion. Berkan, O., Göl, M.K., Içağasioğlu, S., Cetnkaya, O., Yildiz, E., Doğan, K., Günay, I. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. (2004) [Pubmed]
  5. Proteomic analysis of injured spinal cord tissue proteins using 2-DE and MALDI-TOF MS. Kang, S.K., So, H.H., Moon, Y.S., Kim, C.H. Proteomics (2006) [Pubmed]
  6. Expression of a thioredoxin peroxidase in insulin-producing cells. Boschero, A.C., Stoppiglia, L.F., Collares-Buzato, C.B., Bosqueiro, J.R., Delghingaro-Augusto, V., Leite, A., Carvalho, C.P., Netto, L.E., Carneiro, E.M. Diabetes Metab. (2002) [Pubmed]
  7. A comparison of succinyladenylate lyase activity and serum sialic acid as markers of malignancy. Mack, D.O., Lewis, E.M., Butler, E.M., Archer, W.H., Smith, L.D. Biochemical medicine. (1985) [Pubmed]
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