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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

CCL27/PESKY: a novel paradigm for chemokine function.

Chemokines play a central role in regulating leukocyte migration. The recently discovered CC chemokine ligand 27 (CCL27), through interaction with its cognate receptor, CC chemokine receptor 10 ( CCR10), appears to be involved in attracting a subset of memory T cells to the skin during some cutaneous inflammatory responses. Strangely, CCL27 can also be produced as a non-secreted form, as a result of alternative splicing. This protein, termed PESKY, is targeted to the nucleus where it is able to modulate transcription and alter cell morphology. Specifically, PESKY induces a rearrangement of the actin cytoskeleton, manifest by the disruption of stress fibres. This consequently enhances cell motility. Surprisingly, secreted CCL27 can also reach the nucleus after CCR10-mediated internalisation, where it may also be capable of directly modulating transcription to alter cell behaviour. This review will discuss these unprecedented findings.[1]


  1. CCL27/PESKY: a novel paradigm for chemokine function. Nibbs, R.J., Graham, G.J. Expert opinion on biological therapy. (2003) [Pubmed]
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