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Gene Review

CCL27  -  chemokine (C-C motif) ligand 27

Homo sapiens

Synonyms: ALP, C-C motif chemokine 27, CC chemokine ILC, CTACK, CTAK, ...
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Disease relevance of CCL27


High impact information on CCL27


Chemical compound and disease context of CCL27

  • Expression of vascular endothelial growth factor, apoptosis inhibitors (survivin and p16) and CCL27 in alopecia areata before and after diphencyprone treatment: an immunohistochemical study [10].
  • Alendronate-treated women with at least a 30% reduction in bone ALP had a lower risk of non-spine (RH = 0.72; CI: 0.55, 0.92) and hip fractures (RH = 0.26; CI: 0.08, 0.83) relative to those with reductions <30% [11].
  • The Spanish Lung Cancer Group (SLCG) compared the GC regimen with an etoposide plus cisplatin combination (EP), the Hoosier Oncology Group (HOG) compared it with single-agent cisplatin, and the Italian Lung Cancer Project (ILCP) compared it with a mitomycin plus ifosfamide plus cisplatin combination (MIC) [12].
  • Cases were analyzed for local failure (LF) with respect to histology (invasive ductal (IDC), IDC with associated DCIS (IDC/DCIS), invasive lobular (ILC)), age, tumor size, total excision volume, reexcision, total dose, tamoxifen therapy, and chemotherapy [13].
  • As expected, the decrease of both bone formation markers (bone ALP and PINP) was delayed compared to that of bone resorption and significant (p < 0.05-0.01) only after 2 months of treatment in the estrogen-treated group compared to the placebo group [14].

Biological context of CCL27


Anatomical context of CCL27


Associations of CCL27 with chemical compounds

  • In conclusion, local CCL27-mediated retention of CCR10+ CD4+ T cells in sites previously challenged by ACD could be responsible for phenomena such as local skin memory observed in retest reactions and flare-up reactions in which the presence of persisting T cells results in an accelerated inflammatory response upon renewed allergen challenge [5].
  • Intracellular Ca(2+) chelator BAPTA/AM or cyclic adenosine monophosphate (cAMP)-dependent protein kinase inhibitor H-89 partially blocked the inhibitory effects of PGE(2) on CCL27 production and NF-kappaB activity, and the addition of both completely abrogated the inhibition [22].
  • Prostaglandin E(2) suppresses CCL27 production through EP2 and EP3 receptors in human keratinocytes [22].
  • Furthermore, in 7 patients with AD, serum TARC and CTACK levels were studied after the start of systemic cyclosporin A treatment [23].
  • Biochemical parameters (serum albumin, bilirubin, ALP, AST and ALT), lipid peroxides, hydroxyproline, as well as histological changes in liver tissues were analyzed [24].

Regulatory relationships of CCL27


Other interactions of CCL27


Analytical, diagnostic and therapeutic context of CCL27

  • METHODS: Keratinocytes were incubated with TNF-alpha in the presence or absence of PGE(2) . CCL27 secretion and mRNA level were analyzed by means of ELISA and RT-PCR, respectively [22].
  • CCL27 secretion and mRNA levels were analyzed by means of ELISA and RT-PCR, respectively [25].
  • Aim of this study was to investigate using immunohistochemistry techniques the interrelation between T immunoreactive cells and the expression of CCR10 and its ligand CCL27 in 59 cutaneous melanocytic lesions [29].
  • In the present study, we investigated the role of CCL27, a T cell skin-homing chemokine known to be elevated in sera of human AD patients, in disease development in our animal model of AD [17].
  • OBJECTIVE: To compare the efficacy of arthroscopic lavage plus administration of corticosteroids (ALC), arthroscopic lavage plus administration of placebo (ALP), and joint aspiration plus administration of corticosteroids (JAC) in knee arthritis, and to evaluate whether clinical or histologic characteristics determine outcome [8].


  1. Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). Homey, B., Wang, W., Soto, H., Buchanan, M.E., Wiesenborn, A., Catron, D., Müller, A., McClanahan, T.K., Dieu-Nosjean, M.C., Orozco, R., Ruzicka, T., Lehmann, P., Oldham, E., Zlotnik, A. J. Immunol. (2000) [Pubmed]
  2. Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris. Kakinuma, T., Saeki, H., Tsunemi, Y., Fujita, H., Asano, N., Mitsui, H., Tada, Y., Wakugawa, M., Watanabe, T., Torii, H., Komine, M., Asahina, A., Nakamura, K., Tamaki, K. J. Allergy Clin. Immunol. (2003) [Pubmed]
  3. Tumor necrosis factor-alpha-induced CTACK/CCL27 (cutaneous T-cell-attracting chemokine) production in keratinocytes is controlled by nuclear factor kappaB. Vestergaard, C., Johansen, C., Otkjaer, K., Deleuran, M., Iversen, L. Cytokine (2005) [Pubmed]
  4. Chemokines in onchocerciasis patients after a single dose of ivermectin. Fendt, J., Hamm, D.M., Banla, M., Schulz-Key, H., Wolf, H., Helling-Giese, G., Heuschkel, C., Soboslay, P.T. Clin. Exp. Immunol. (2005) [Pubmed]
  5. Increased CCL27-CCR10 expression in allergic contact dermatitis: implications for local skin memory. Moed, H., Boorsma, D.M., Tensen, C.P., Flier, J., Jonker, M.J., Stoof, T.J., von Blomberg, B.M., Bruynzeel, D.P., Scheper, R.J., Rustemeyer, T., Gibbs, S. J. Pathol. (2004) [Pubmed]
  6. Antitumor effect by interleukin-11 receptor alpha-locus chemokine/CCL27, introduced into tumor cells through a recombinant adenovirus vector. Gao, J.Q., Tsuda, Y., Katayama, K., Nakayama, T., Hatanaka, Y., Tani, Y., Mizuguchi, H., Hayakawa, T., Yoshie, O., Tsutsumi, Y., Mayumi, T., Nakagawa, S. Cancer Res. (2003) [Pubmed]
  7. Evaluation of a new endoscopic index to predict first bleeding from the upper gastrointestinal tract in patients with cirrhosis. Zoli, M., Merkel, C., Magalotti, D., Marchesini, G., Gatta, A., Pisi, E. Hepatology (1996) [Pubmed]
  8. Comparison of efficacy of arthroscopic lavage plus administration of corticosteroids, arthroscopic lavage plus administration of placebo, and joint aspiration plus administration of corticosteroids in arthritis of the knee: A randomized controlled trial. van Oosterhout, M., Sont, J.K., Bajema, I.M., Breedveld, F.C., van Laar, J.M. Arthritis Rheum. (2006) [Pubmed]
  9. Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: An amplification cycle triggering cutaneous lupus erythematosus. Meller, S., Winterberg, F., Gilliet, M., Müller, A., Lauceviciute, I., Rieker, J., Neumann, N.J., Kubitza, R., Gombert, M., Bünemann, E., Wiesner, U., Franken-Kunkel, P., Kanzler, H., Dieu-Nosjean, M.C., Amara, A., Ruzicka, T., Lehmann, P., Zlotnik, A., Homey, B. Arthritis Rheum. (2005) [Pubmed]
  10. Expression of vascular endothelial growth factor, apoptosis inhibitors (survivin and p16) and CCL27 in alopecia areata before and after diphencyprone treatment: an immunohistochemical study. Simonetti, O., Lucarini, G., Bernardini, M.L., Simoncini, C., Biagini, G., Offidani, A. Br. J. Dermatol. (2004) [Pubmed]
  11. Change in bone turnover and hip, non-spine, and vertebral fracture in alendronate-treated women: the fracture intervention trial. Bauer, D.C., Black, D.M., Garnero, P., Hochberg, M., Ott, S., Orloff, J., Thompson, D.E., Ewing, S.K., Delmas, P.D. J. Bone Miner. Res. (2004) [Pubmed]
  12. The activity of gemcitabine plus cisplatin in randomized trials in untreated patients with advanced non-small cell lung cancer. Rosell, R., Tonato, M., Sandler, A. Semin. Oncol. (1998) [Pubmed]
  13. Factors determining outcome for breast-conserving irradiation with margin-directed dose escalation to the tumor bed. Wazer, D.E., Schmidt-Ullrich, R.K., Ruthazer, R., Schmid, C.H., Graham, R., Safaii, H., Rothschild, J., McGrath, J., Erban, J.K. Int. J. Radiat. Oncol. Biol. Phys. (1998) [Pubmed]
  14. Short-term effects of new synthetic conjugated estrogens on biochemical markers of bone turnover. Garnero, P., Stevens, R.E., Ayres, S.A., Phelps, K.V. Journal of clinical pharmacology. (2002) [Pubmed]
  15. CCL28 production in HaCaT cells was mediated by different signal pathways from CCL27. Kagami, S., Saeki, H., Komine, M., Kakinuma, T., Nakamura, K., Tsunemi, Y., Sasaki, K., Asahina, A., Tamaki, K. Exp. Dermatol. (2006) [Pubmed]
  16. CCL27/PESKY: a novel paradigm for chemokine function. Nibbs, R.J., Graham, G.J. Expert opinion on biological therapy. (2003) [Pubmed]
  17. CCL27 is a critical factor for the development of atopic dermatitis in the keratin-14 IL-4 transgenic mouse model. Chen, L., Lin, S.X., Agha-Majzoub, R., Overbergh, L., Mathieu, C., Chan, L.S. Int. Immunol. (2006) [Pubmed]
  18. CTACK/CCL27 Accelerates Skin Regeneration via Accumulation of Bone Marrow-Derived Keratinocytes. Inokuma, D., Abe, R., Fujita, Y., Sasaki, M., Shibaki, A., Nakamura, H., McMillan, J.R., Shimizu, T., Shimizu, H. Stem Cells (2006) [Pubmed]
  19. Residues determining the binding specificity of uncompetitive inhibitors to tissue-nonspecific alkaline phosphatase. Kozlenkov, A., Le Du, M.H., Cuniasse, P., Ny, T., Hoylaerts, M.F., Millán, J.L. J. Bone Miner. Res. (2004) [Pubmed]
  20. Insulin-like growth factor I-stimulated melanoma cell migration requires phosphoinositide 3-kinase but not extracellular-regulated kinase activation. Neudauer, C.L., McCarthy, J.B. Exp. Cell Res. (2003) [Pubmed]
  21. Trafficking pathways and characterization of CD4 and CD8 cells recruited to the skin of humans experimentally infected with Haemophilus ducreyi. Humphreys, T.L., Baldridge, L.A., Billings, S.D., Campbell, J.J., Spinola, S.M. Infect. Immun. (2005) [Pubmed]
  22. Prostaglandin E(2) suppresses CCL27 production through EP2 and EP3 receptors in human keratinocytes. Kanda, N., Mitsui, H., Watanabe, S. J. Allergy Clin. Immunol. (2004) [Pubmed]
  23. Serum thymus and activation-regulated chemokine (TARC) and cutaneous T cell- attracting chemokine (CTACK) levels in allergic diseases: TARC and CTACK are disease-specific markers for atopic dermatitis. Hijnen, D., De Bruin-Weller, M., Oosting, B., Lebre, C., De Jong, E., Bruijnzeel-Koomen, C., Knol, E. J. Allergy Clin. Immunol. (2004) [Pubmed]
  24. An herbal formula, CGX, exerts hepatotherapeutic effects on dimethylnitrosamine-induced chronic liver injury model in rats. Shin, J.W., Son, J.Y., Oh, S.M., Han, S.H., Wang, J.H., Cho, J.H., Cho, C.K., Yoo, H.S., Lee, Y.W., Lee, M.M., Hu, X.P., Son, C.G. World J. Gastroenterol. (2006) [Pubmed]
  25. IL-17 suppresses TNF-alpha-induced CCL27 production through induction of COX-2 in human keratinocytes. Kanda, N., Koike, S., Watanabe, S. J. Allergy Clin. Immunol. (2005) [Pubmed]
  26. A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. Pan, J., Kunkel, E.J., Gosslar, U., Lazarus, N., Langdon, P., Broadwell, K., Vierra, M.A., Genovese, M.C., Butcher, E.C., Soler, D. J. Immunol. (2000) [Pubmed]
  27. Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine. Jarmin, D.I., Rits, M., Bota, D., Gerard, N.P., Graham, G.J., Clark-Lewis, I., Gerard, C. J. Immunol. (2000) [Pubmed]
  28. Suppressive effects of antimycotics on tumor necrosis factor-alpha-induced CCL27, CCL2, and CCL5 production in human keratinocytes. Kanda, N., Watanabe, S. Biochem. Pharmacol. (2006) [Pubmed]
  29. Potential role of CCL27 and CCR10 expression in melanoma progression and immune escape. Simonetti, O., Goteri, G., Lucarini, G., Filosa, A., Pieramici, T., Rubini, C., Biagini, G., Offidani, A. Eur. J. Cancer (2006) [Pubmed]
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