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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Narcolepsy-like symptoms in a patient with down syndrome and without obstructive sleep apnea.

OBJECTIVE: The study reports on a 33-year-old Caucasian female with Down syndrome and narcolepsy-like symptoms. METHOD: After medical and genetic screening, docturnal polysomnography followed by a Multiple Sleep Latency Test and HLA typing were performed. The patient was medication free and reported a number of cataplexy attacks everyday. Each time that she came to the sleep disorders clinic, she was observed to have cataplexy. She also felt extremely drowsy. A mean sleep latency of 8.8 minutes with 4 sleep-onset rapid eye movement periods in the Multiple Sleep Latency Test, with no other sleep disorder that accounts for the symptoms, was obtained. The patient was DQB1*0301, DQB1*0602, as revealed by the last high-resolution serologic typing.[1]

References

  1. Narcolepsy-like symptoms in a patient with down syndrome and without obstructive sleep apnea. Dominguez-Ortega, L., Salin-Pascual, R.J., Díaz-Gállego, E. Sleep. (2003) [Pubmed]
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