The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Sleep Disorders

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Sleep Disorders


Psychiatry related information on Sleep Disorders


High impact information on Sleep Disorders


Chemical compound and disease context of Sleep Disorders


Biological context of Sleep Disorders


Anatomical context of Sleep Disorders


Gene context of Sleep Disorders

  • This raises the question of whether more direct interventions such as CRH receptor antagonists would open a new lead in the treatment of stress-related disorders such as depression, anxiety and sleep disorders [29].
  • Mutation screening of the human Clock gene in circadian rhythm sleep disorders [30].
  • Sleep disorders are common in NCL patients [31].
  • Results highlight the prominence of parent-reported sleep disturbance in children with ADHD and the need for clinicians to routinely screen for the presence of sleep disorders and assess detailed sleep physiology where indicated [32].
  • These results are consistent with the hypothesis that an age-related deterioration occurs in the Hcrt system that may contribute to age-related sleep disorders [33].

Analytical, diagnostic and therapeutic context of Sleep Disorders

  • These clinical guidelines were developed by the Standards of Practice Committee and reviewed and approved by the Board of Directors of the American Academy of Sleep Medicine. The guidelines provide recommendations for the practice of sleep medicine in North America regarding the use of light therapy for treatment of various sleep disorders [34].
  • Because cyclic alternating pattern can also be measured in CIPA, clinical exploitation of this phenomenon could include monitoring of epilepsy, studies of the effects of drug therapy, and assessment of other sleep disorders [35].
  • Recognition of the variety of generalized and partial epileptic syndromes associated with sleep, familiarity with the differential diagnosis of nocturnal spells, and awareness of the role that antiepileptic drugs and sleep disorders may play in epilepsy are helpful in evaluating patients presenting with behavioral and motor disturbances of sleep [36].
  • Finally, we predict the possible future promises for complementary and alternative medicine (CAM) that pave the way to the emergence of a "Holistic Sleep Medicine" approach to the treatment of sleep disorders in the ageing population [37].
  • Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis [38].


  1. Delayed sleep phase syndrome response to melatonin. Dahlitz, M., Alvarez, B., Vignau, J., English, J., Arendt, J., Parkes, J.D. Lancet (1991) [Pubmed]
  2. Objective and subjective sleep disturbances in patients with systemic lupus erythematosus. Valencia-Flores, M., Resendiz, M., Castaño, V.A., Santiago, V., Campos, R.M., Sandino, S., Valencia, X., Alcocer, J., Ramos, G.G., Bliwise, D.L. Arthritis Rheum. (1999) [Pubmed]
  3. Importance of sleep restoration in co-morbid disease: effect of anticonvulsants. Ehrenberg, B. Neurology (2000) [Pubmed]
  4. Selective histamine H3 receptor antagonists for treatment of cognitive deficiencies and other disorders of the central nervous system. Witkin, J.M., Nelson, D.L. Pharmacol. Ther. (2004) [Pubmed]
  5. The effects of breathing-related sleep disorders on mood disturbances in the general population. Ohayon, M.M. The Journal of clinical psychiatry. (2003) [Pubmed]
  6. Objective and subjective sleep disturbances in patients with rheumatoid arthritis. A reappraisal. Hirsch, M., Carlander, B., Vergé, M., Tafti, M., Anaya, J.M., Billiard, M., Sany, J. Arthritis Rheum. (1994) [Pubmed]
  7. Month of birth as a risk factor for narcolepsy. Dauvilliers, Y., Carlander, B., Molinari, N., Desautels, A., Okun, M., Tafti, M., Montplaisir, J., Mignot, E., Billiard, M. Sleep. (2003) [Pubmed]
  8. Clinical pharmacology, therapeutic use and potential of COMT inhibitors in Parkinson's disease. Kaakkola, S. Drugs (2000) [Pubmed]
  9. Mefloquine induces dose-related neurological effects in a rat model. Dow, G., Bauman, R., Caridha, D., Cabezas, M., Du, F., Gomez-Lobo, R., Park, M., Smith, K., Cannard, K. Antimicrob. Agents Chemother. (2006) [Pubmed]
  10. Fluoxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Benfield, P., Heel, R.C., Lewis, S.P. Drugs (1986) [Pubmed]
  11. The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. Kilduff, T.S., Peyron, C. Trends Neurosci. (2000) [Pubmed]
  12. Effect of sleep deprivation on overall 24 h growth-hormone secretion. Brandenberger, G., Gronfier, C., Chapotot, F., Simon, C., Piquard, F. Lancet (2000) [Pubmed]
  13. Improvement of sleep quality in elderly people by controlled-release melatonin. Garfinkel, D., Laudon, M., Nof, D., Zisapel, N. Lancet (1995) [Pubmed]
  14. The histamine H3 receptor as a novel therapeutic target for cognitive and sleep disorders. Passani, M.B., Lin, J.S., Hancock, A., Crochet, S., Blandina, P. Trends Pharmacol. Sci. (2004) [Pubmed]
  15. Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. Boger, D.L., Sato, H., Lerner, A.E., Hedrick, M.P., Fecik, R.A., Miyauchi, H., Wilkie, G.D., Austin, B.J., Patricelli, M.P., Cravatt, B.F. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  16. GABA, gamma-hydroxybutyric acid, and neurological disease. Wong, C.G., Bottiglieri, T., Snead, O.C. Ann. Neurol. (2003) [Pubmed]
  17. Plasma endogenous benzodiazepine-like activity in sleep disorders with excessive daytime sleepiness. Montagna, P., Sforza, E., Tinuper, P., Provini, F., Plazzi, G., Cortelli, P., Schoch, P., Rothstein, J.D., Lugaresi, E. Neurology (1995) [Pubmed]
  18. An electrocardiogram-based technique to assess cardiopulmonary coupling during sleep. Thomas, R.J., Mietus, J.E., Peng, C.K., Goldberger, A.L. Sleep. (2005) [Pubmed]
  19. Sleep disorders and depression with atypical features: response to valproate. Pies, R., Adler, D.A., Ehrenberg, B.L. Journal of clinical psychopharmacology. (1989) [Pubmed]
  20. Dopaminergic agents in restless legs syndrome and periodic limb movements of sleep: response and complications of extended treatment in 49 cases. Becker, P.M., Jamieson, A.O., Brown, W.D. Sleep. (1993) [Pubmed]
  21. Mechanism-based inhibition of the melatonin rhythm enzyme: pharmacologic exploitation of active site functional plasticity. Khalil, E.M., De Angelis, J., Ishii, M., Cole, P.A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  22. Sleep disorders and ADHD: shared and common phenotypes. Lewin, D.S., Di Pinto, M. Sleep. (2004) [Pubmed]
  23. Predictors of sleepiness in epilepsy patients. Malow, B.A., Bowes, R.J., Lin, X. Sleep. (1997) [Pubmed]
  24. Narcolepsy-cataplexy in Israeli Jews is associated exclusively with the HLA DR2 haplotype. A study at the serological and genomic level. Wilner, A., Steinman, L., Lavie, P., Peled, R., Friedmann, A., Brautbar, C. Hum. Immunol. (1988) [Pubmed]
  25. Genes for normal sleep and sleep disorders. Tafti, M., Maret, S., Dauvilliers, Y. Ann. Med. (2005) [Pubmed]
  26. Hypocretin/orexin and sleep: implications for the pathophysiology and diagnosis of narcolepsy. Overeem, S., Scammell, T.E., Lammers, G.J. Curr. Opin. Neurol. (2002) [Pubmed]
  27. Post-streptococcal autoimmune disorders of the central nervous system. Dale, R.C. Developmental medicine and child neurology. (2005) [Pubmed]
  28. Donepezil for Alzheimer's disease: pharmacodynamic, pharmacokinetic, and clinical profiles. Shigeta, M., Homma, A. CNS drug reviews. (2001) [Pubmed]
  29. Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders. Keck, M.E., Holsboer, F. Peptides (2001) [Pubmed]
  30. Mutation screening of the human Clock gene in circadian rhythm sleep disorders. Iwase, T., Kajimura, N., Uchiyama, M., Ebisawa, T., Yoshimura, K., Kamei, Y., Shibui, K., Kim, K., Kudo, Y., Katoh, M., Watanabe, T., Nakajima, T., Ozeki, Y., Sugishita, M., Hori, T., Ikeda, M., Toyoshima, R., Inoue, Y., Yamada, N., Mishima, K., Nomura, M., Ozaki, N., Okawa, M., Takahashi, K., Yamauchi, T. Psychiatry research. (2002) [Pubmed]
  31. Circadian rhythm studies in neuronal ceroid-lipofuscinosis (NCL). Heikkilä, E., Hàtònen, T.H., Telakivi, T., Laakso, M.L., Heiskala, H., Salmi, T., Alila, A., Santavuori, P. Am. J. Med. Genet. (1995) [Pubmed]
  32. Actigraphic and parent reports of sleep patterns and sleep disorders in children with subtypes of attention-deficit hyperactivity disorder. Wiggs, L., Montgomery, P., Stores, G. Sleep. (2005) [Pubmed]
  33. Age-related decline in hypocretin (orexin) receptor 2 messenger RNA levels in the mouse brain. Terao, A., Apte-Deshpande, A., Morairty, S., Freund, Y.R., Kilduff, T.S. Neurosci. Lett. (2002) [Pubmed]
  34. Practice parameters for the use of light therapy in the treatment of sleep disorders. Standards of Practice Committee, American Academy of Sleep Medicine. Chesson, A.L., Littner, M., Davila, D., Anderson, W.M., Grigg-Damberger, M., Hartse, K., Johnson, S., Wise, M. Sleep. (1999) [Pubmed]
  35. Periodicity of a noninvasive measure of cardiac vagal tone during non-rapid eye movement sleep in non-sleep deprived and sleep-deprived normal subjects. Delamont, R.S., Julu, P.O., Jamal, G.A. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. (1999) [Pubmed]
  36. Sleep and epilepsy. Malow, B.A. Neurologic clinics. (2005) [Pubmed]
  37. Senescence, sleep, and circadian rhythms. Pandi-Perumal, S.R., Seils, L.K., Kayumov, L., Ralph, M.R., Lowe, A., Moller, H., Swaab, D.F. Ageing Res. Rev. (2002) [Pubmed]
  38. Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis. Buscemi, N., Vandermeer, B., Hooton, N., Pandya, R., Tjosvold, L., Hartling, L., Vohra, S., Klassen, T.P., Baker, G. BMJ (2006) [Pubmed]
WikiGenes - Universities