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MeSH Review

Histocompatibility Testing

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Disease relevance of Histocompatibility Testing


Psychiatry related information on Histocompatibility Testing


High impact information on Histocompatibility Testing

  • Thus, precisely targeted immunotherapy directed against antigen MZ2-E could be provided to individuals identified by HLA typing and analysis of the RNA of a small tumor sample [7].
  • Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children [8].
  • HLA typing showed HLA-DR3 in 61% of patients (controls 22%, Pc less than 0.005) and the combination of DR3, DR4 in 43% (controls 3%, Pc less than 0.00001) [9].
  • Only 4 patients had the typical HLA typing of celiac disease [10].
  • Antibodies to gluten, folic acid serum concentrations, were measured, and HLA typing was done in most patients [11].

Chemical compound and disease context of Histocompatibility Testing


Biological context of Histocompatibility Testing


Anatomical context of Histocompatibility Testing


Associations of Histocompatibility Testing with chemical compounds

  • PATIENTS AND METHODS: After induction therapy that randomized patients to receive one of two anthracycline-containing regimens, either daunorubicin (DNR) or zorubicin (ZRB), patients were assigned to postremission treatment according to age and results of HLA typing [24].
  • Another sister and her daughter had different HLA typing and had no detectable abnormalities of cortisol secretion [25].
  • We describe a 19-year-old woman with typical MG and heterozygous C2 deficiency, along with HLA typing of the patient and her immediate family [26].
  • HLA typing was carried out by the PCR-RFLP method, which allowed discrimination of most HLA DQA1, DQB1, DPB1, and DRB alleles [27].
  • Determination of intracellular adenosine triphosphate for detecting anti-HLA antibody-mediated cytolysis. Introduction to a new method for HLA typing [28].

Gene context of Histocompatibility Testing

  • Fifty-three patients with SCA underwent complete HLA typing at both HLA class I (HLA-A, B) and HLA class II (HLA-DR, DQ, DP) loci [29].
  • Comparison of the results of HLA typing between the SCA patients with a positive and those with a negative MRI documented that the 2 groups differed with respect to the class I HLA-B (P =.012), and the class II HLA-DRB1 (P =.0008) and DQB1 (P =.029) [29].
  • The genomic HLA typing, performed on the DRB1 and DRB5 genes in the DR2+ subjects, showed no obvious correspondence between preferential responses to regions of MBP and HLA-DR2 subtypes [30].
  • DNA-based HLA typing for DRB1, DQB1, and DPB1 was performed on 16 consistently RF--patients with erosive RA [31].
  • Thus, the PCR-RFLP method is technically simple, practical and inexpensive for determination of the HLA-DRB1 alleles for routine HLA typing work [32].

Analytical, diagnostic and therapeutic context of Histocompatibility Testing


  1. Idiopathic hemochromatosis. Demonstration of recessive transmission and early detection by family HLA typing. Simon, M., Bourel, M., Genetet, B., Fauchet, R. N. Engl. J. Med. (1977) [Pubmed]
  2. Tissue typing the HLA-A locus from genomic DNA by sequence-specific PCR: comparison of HLA genotype and surface expression on colorectal tumor cell lines. Browning, M.J., Krausa, P., Rowan, A., Bicknell, D.C., Bodmer, J.G., Bodmer, W.F. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  3. Aspartic acid homozygosity at codon 57 of HLA-DQ beta is associated with susceptibility to pulmonary tuberculosis in Cambodia. Delgado, J.C., Baena, A., Thim, S., Goldfeld, A.E. J. Immunol. (2006) [Pubmed]
  4. Hereditary articular chondrocalcinosis. Clinical and genetic features in 13 pedigrees. Rodriguez-Valverde, V., Zuniga, M., Casanueva, B., Sanchez, S., Merino, J. Am. J. Med. (1988) [Pubmed]
  5. Detection of heterozygotes for congenital adrenal hyperplasia: 21-hydroxylase deficiency-a comparison of HLA typing and 17-OH progesterone response to ACTH infusion. Mauseth, R.S., Hansen, J.A., Smith, E.K., Giblett, E.R., Kelley, V.C. J. Pediatr. (1980) [Pubmed]
  6. Posttraumatic narcolepsy: the complete syndrome with tissue typing. Case report. Good, J.L., Barry, E., Fishman, P.S. J. Neurosurg. (1989) [Pubmed]
  7. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. van der Bruggen, P., Traversari, C., Chomez, P., Lurquin, C., De Plaen, E., Van den Eynde, B., Knuth, A., Boon, T. Science (1991) [Pubmed]
  8. Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children. Hagopian, W.A., Sanjeevi, C.B., Kockum, I., Landin-Olsson, M., Karlsen, A.E., Sundkvist, G., Dahlquist, G., Palmer, J., Lernmark, A. J. Clin. Invest. (1995) [Pubmed]
  9. High frequency of histocompatibility antigens HLA-DR3 and DR4 in herpes gestations. Shornick, J.K., Stastny, P., Gilliam, J.N. J. Clin. Invest. (1981) [Pubmed]
  10. Gluten-sensitive disease with mild enteropathy. Picarelli, A., Maiuri, L., Mazzilli, M.C., Coletta, S., Ferrante, P., Di Giovambattista, F., Greco, M., Torsoli, A., Auricchio, S. Gastroenterology (1996) [Pubmed]
  11. Coeliac disease, epilepsy, and cerebral calcifications. The Italian Working Group on Coeliac Disease and Epilepsy. Gobbi, G., Bouquet, F., Greco, L., Lambertini, A., Tassinari, C.A., Ventura, A., Zaniboni, M.G. Lancet (1992) [Pubmed]
  12. Predictive value of HLA antigen for methotrexate-induced liver damage in patients with psoriasis. Pestana, A., Halprin, K.M., Taylor, J.R., Schiff, E.R., Esquenazi, V., Comerford, M., Gomez, C. J. Am. Acad. Dermatol. (1985) [Pubmed]
  13. Prenatal diagnosis of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency by steroid analysis in the amniotic fluid of mid-pregnancy: comparison with HLA typing in 17 pregnancies at risk for CAH. Forest, M.G., Bétuel, H., Couillin, P., Boué, A. Prenat. Diagn. (1981) [Pubmed]
  14. Evidence for recessive and against dominant inheritance at the HLA-"linked" locus in coeliac disease. Greenberg, D.A., Hodge, S.E., Rotter, J.I. Am. J. Hum. Genet. (1982) [Pubmed]
  15. Diagnosis and management of hereditary hemochromatosis. Valberg, L.S., Ghent, C.N. Annu. Rev. Med. (1985) [Pubmed]
  16. Immunogenicity of intraperitoneal insulin infusion using programmable implantable devices. Jeandidier, N., Boivin, S., Sapin, R., Rosart-Ortega, F., Uring-Lambert, B., Réville, P., Pinget, M. Diabetologia (1995) [Pubmed]
  17. An HLA-associated nonresponsiveness to mellitin: a component of bee venom. Lympany, P., Kemeny, D.M., Welsh, K.I., Lee, T.H. J. Allergy Clin. Immunol. (1990) [Pubmed]
  18. Predictive value of human leukocyte antigen class II typing for the development of islet autoantibodies and insulin-dependent diabetes postpartum in women with gestational diabetes. Ferber, K.M., Keller, E., Albert, E.D., Ziegler, A.G. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  19. Virilization without adrenal hyperplasia in 21-hydroxylase deficiency during fetal life. Kuhnle, U., Böhm, N., Wolff, G., Mayerová, A., Dörr, H.G., Bidlingmaier, F., Knorr, D. J. Clin. Endocrinol. Metab. (1984) [Pubmed]
  20. Changing concepts of the epidemiology of insulin-dependent diabetes. Bennett, P.H. Diabetes Care (1985) [Pubmed]
  21. Specificity of human T lymphocytes expressing a gamma/delta T cell antigen receptor. Recognition of a polymorphic determinant of HLA class I molecules by a gamma/delta clone. Ciccone, E., Viale, O., Pende, D., Malnati, M., Battista Ferrara, G., Barocci, S., Moretta, A., Moretta, L. Eur. J. Immunol. (1989) [Pubmed]
  22. Report of a case of immunosuppression with prednisone in an 8-year-old boy with an acute onset of hypocretin-deficiency narcolepsy. Hecht, M., Lin, L., Kushida, C.A., Umetsu, D.T., Taheri, S., Einen, M., Mignot, E. Sleep. (2003) [Pubmed]
  23. Two siblings with acute T-cell lymphocytic leukemia. Weber, W., Müller, H., Moroni, C., von Fliedner, V., Sartorius, J.A., Speck, B., Obrecht, J.P., Jeannet, M. Int. J. Cancer (1980) [Pubmed]
  24. Adult acute lymphoblastic leukemia: a multicentric randomized trial testing bone marrow transplantation as postremission therapy. The French Group on Therapy for Adult Acute Lymphoblastic Leukemia. Fière, D., Lepage, E., Sebban, C., Boucheix, C., Gisselbrecht, C., Vernant, J.P., Varet, B., Broustet, A., Cahn, J.Y., Rigal-Huguet, F. J. Clin. Oncol. (1993) [Pubmed]
  25. Familial Cushing's syndrome. Micronodular adrenocortical dysplasia. Hodge, B.O., Froesch, T.A. Arch. Intern. Med. (1988) [Pubmed]
  26. Heterozygous C2-deficiency and myasthenia gravis. Riggs, J.E., Griggs, R.C., Rosenfeld, S.I., May, A.G., Penn, A.S. Neurology (1980) [Pubmed]
  27. HLA class II alleles in isocyanate-induced asthma. Bignon, J.S., Aron, Y., Ju, L.Y., Kopferschmitt, M.C., Garnier, R., Mapp, C., Fabbri, L.M., Pauli, G., Lockhart, A., Charron, D. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  28. Determination of intracellular adenosine triphosphate for detecting anti-HLA antibody-mediated cytolysis. Introduction to a new method for HLA typing. Descamps, B. Transplantation (1980) [Pubmed]
  29. Evidence for HLA-related susceptibility for stroke in children with sickle cell disease. Styles, L.A., Hoppe, C., Klitz, W., Vichinsky, E., Lubin, B., Trachtenberg, E. Blood (2000) [Pubmed]
  30. Predominant and stable T cell responses to regions of myelin basic protein can be detected in individual patients with multiple sclerosis. Salvetti, M., Ristori, G., D'Amato, M., Buttinelli, C., Falcone, M., Fieschi, C., Wekerle, H., Pozzilli, C. Eur. J. Immunol. (1993) [Pubmed]
  31. Erosive rheumatoid factor negative and positive rheumatoid arthritis are immunogenetically similar. Vehe, R.K., Nepom, G.T., Wilske, K.R., Stage, D., Begovich, A.B., Nepom, B.S. J. Rheumatol. (1994) [Pubmed]
  32. HLA-DRB1 genotyping by modified PCR-RFLP method combined with group-specific primers. Ota, M., Seki, T., Fukushima, H., Tsuji, K., Inoko, H. Tissue Antigens (1992) [Pubmed]
  33. Arthritis of hemochromatosis. Clinical spectrum, relation to histocompatibility antigens, and effectiveness of early phlebotomy. Askari, A.D., Muir, W.A., Rosner, I.A., Moskowitz, R.W., McLaren, G.D., Braun, W.E. Am. J. Med. (1983) [Pubmed]
  34. Lack of association between HLA-DR antigens and sleep-onset REM periods in major depression. Staner, L., Bouillon, E., Andrien, M., Dupont, E., Mendlewicz, J. Biol. Psychiatry (1991) [Pubmed]
  35. Prenatal identification of potential donors for umbilical cord blood transplantation for Fanconi anemia. Auerbach, A.D., Liu, Q., Ghosh, R., Pollack, M.S., Douglas, G.W., Broxmeyer, H.E. Transfusion (1990) [Pubmed]
  36. Experience with live donor nephrectomy. Weinstein, S.H., Navarre, R.J., Loening, S.A., Corry, R.J. J. Urol. (1980) [Pubmed]
  37. HLA typing of cultured amniotic fluid cells. Whitsett, C.F., Priest, J.H., Priest, R.E., Marion, J. Am. J. Clin. Pathol. (1983) [Pubmed]
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