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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Centrosome size is controlled by centriolar SAS-4.

The centrosome consists of a pair of centrioles and a surrounding matrix of pericentriolar material that anchors microtubule nucleation sites and consequently determines the number and organization of microtubules in interphase and mitotic cells. Recent studies utilizing a functional genomics approach in the nematode worm Caenorhabditis elegans and sophisticated light and electron microscopy techniques provide new insight into how centrioles act as centrosomal organizers and use a centriolar structural element to dictate centrosome size by defining their capacity to recruit pericentriolar material.[1]


  1. Centrosome size is controlled by centriolar SAS-4. Salisbury, J.L. Trends Cell Biol. (2003) [Pubmed]
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