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Chen, J. et al.

Chen, Liu, Zhang, Ye, Wang,

Decreased renal vitamin K-dependent gamma-glutamyl carboxylase activity in calcium oxalate calculi patients.

OBJECTIVE: To study the activity of vitamin K-dependent gamma-glutamyl carboxylase in patients with calcium oxalate (CaOx) urolithiasis compared with healthy individuals and to assess its relationship to the renal calcium oxalate urolithiasis. METHODS: Renal parenchymas were harvested from urolithic patients and renal tumor patients undergoing nephrectomy. The renal carboxylase activity was evaluated as the radioactivity of [(14)C] labeled sodium bicarbonate in carboxylic reactions in vitro using beta-liquid scintillation counting. RESULTS: Significantly reduced activity of renal vitamin K-dependent gamma-glutamyl carboxylase was observed in the urolithic group as compared with normal controls (P < 0.01). CONCLUSION: It suggests that the reduced carboxylase activity observed in the urolithic patients may play an important role in the course of renal calcium oxalate urolithiasis.[1]

References

Decreased renal vitamin K-dependent gamma-glutamyl carboxylase activity in calcium oxalate calculi patients. Chen, J., Liu, J., Zhang, Y., Ye, Z., Wang, S. Chin. Med. J. (2003) [Pubmed]

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