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Nouraei, S.A. et al.

Dose-related effect of sevoflurane sedation on higher control of eye movements and decision making.

BACKGROUND: Saccadic latency may provide an objective method to assess sedative doses of anaesthetic on cortical oculomotor mechanisms and decision making. METHODS: We tested the effects of random doses of 0, 0.1, 0.2 and 0.3 MAC sevoflurane in six subjects, in a double-blind study using two measures of behavioural impairment: saccadic latency and stop signal reaction time (SSRT) in a countermanding task. RESULTS: Saccadic latency and SSRT both increased with increasing doses of sevoflurane. In both measures, reciprocal reaction time was linearly related to dose in each subject: all but two of the twelve regression coefficients were statistically significant (P<0.05). In one subject, SSRT was significantly more sensitive than simple latency (P<0.05); for the others there was no significant difference. CONCLUSION: Measurements of this kind could potentially provide estimates of cortical effects of sevoflurane sedation, and give a clinically useful measure of cognitive fitness.[1]

References

Dose-related effect of sevoflurane sedation on higher control of eye movements and decision making. Nouraei, S.A., De Pennington, N., Jones, J.G., Carpenter, R.H. British journal of anaesthesia. (2003) [Pubmed]

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