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Chemical Compound Review

Sevorane     1,1,1,3,3,3-hexafluoro-2...

Synonyms: Sevofrane, Sojourn, Petrem, Sevofluran, Ultane, ...
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Disease relevance of Sevofluran


Psychiatry related information on Sevofluran


High impact information on Sevofluran


Chemical compound and disease context of Sevofluran


Biological context of Sevofluran


Anatomical context of Sevofluran


Associations of Sevofluran with other chemical compounds


Gene context of Sevofluran

  • While almost anesthetics are metabolized by the cytochrome P450 (CYP) 3A4, some major volatile ones such as halothane and sevoflurane are metabolized by CYP2E1 in humans [29].
  • Death signaling was not mediated via the Fas/CD95 receptor pathway because neither anti-Fas/CD95 receptor antagonism nor FADD deficiency or caspase-8 deficiency were able to attenuate sevoflurane-mediated apoptosis [30].
  • Our data suggest that sevoflurane anaesthesia transiently produced an impaired AQP2 response to an increase in intrinsic AVP [31].
  • These data suggest that sevoflurane-produced inhibition of Ang II-induced vasoconstriction is, at least in part, caused by depression of the p44/42 MAPK-mediated signaling pathway [32].
  • Sevoflurane-mediated suppression of AP-1 could be observed in primary CD3 lymphocytes from healthy volunteers, was time-dependent and concentration-dependent, and occurred at concentrations that are clinically achieved [33].

Analytical, diagnostic and therapeutic context of Sevofluran

  • Fifteen patients undergoing comparable operations with SF (approximately one-half as toxic as IF in vitro) and nine patients undergoing regional/ local anesthesia were controls [34].
  • METHODS: Twenty patients (American Society of Anesthesiologists physical status I), aged 20-68 yr undergoing body surface surgery with general anesthesia with sevoflurane were enrolled [35].
  • The authors hypothesized that the vaporizer settings required to maintain constant end-expired sevoflurane concentration (Etsevo) during minimal-flow anesthesia (MFA, fresh gas flow of 0.5 l/min) or low-flow anesthesia (LFA, fresh gas flow of 1 l/min) would be lower when sevoflurane is used in oxygen-nitrous oxide than in oxygen [36].
  • Influence of nitrous oxide on minimum alveolar concentration of sevoflurane for laryngeal mask insertion in children [37].
  • Prediction probability values for EEG parameters and sevoflurane concentration to predict depth of sedation and anesthesia were also calculated [38].


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  16. Role of the beta1-adrenergic pathway in anesthetic and ischemic preconditioning against myocardial infarction in the rabbit heart in vivo. Lange, M., Smul, T.M., Blomeyer, C.A., Redel, A., Klotz, K.N., Roewer, N., Kehl, F. Anesthesiology (2006) [Pubmed]
  17. The effects of fentanyl on sevoflurane requirements for loss of consciousness and skin incision. Katoh, T., Ikeda, K. Anesthesiology (1998) [Pubmed]
  18. Use of a modified cyclodextrin host for the enantioselective detection of a halogenated diether as chiral guest via optical and electrical transducers. Kieser, B., Fietzek, C., Schmidt, R., Belge, G., Weimar, U., Schurig, V., Gauglitz, G. Anal. Chem. (2002) [Pubmed]
  19. Effect of resuscitative mild hypothermia on glutamate and dopamine release, apoptosis and ischaemic brain damage in the endothelin-1 rat model for focal cerebral ischaemia. Van Hemelrijck, A., Vermijlen, D., Hachimi-Idrissi, S., Sarre, S., Ebinger, G., Michotte, Y. J. Neurochem. (2003) [Pubmed]
  20. Comparative hemodynamic depression of sevoflurane versus halothane in infants: an echocardiographic study. Wodey, E., Pladys, P., Copin, C., Lucas, M.M., Chaumont, A., Carre, P., Lelong, B., Azzis, O., Ecoffey, C. Anesthesiology (1997) [Pubmed]
  21. Halothane, isoflurane and sevoflurane inhibit NADH:ubiquinone oxidoreductase (complex I) of cardiac mitochondria. Hanley, P.J., Ray, J., Brandt, U., Daut, J. J. Physiol. (Lond.) (2002) [Pubmed]
  22. Volatile anaesthetic effects on Na+-Ca2+ exchange in rat cardiac myocytes. Seckin, I., Sieck, G.C., Prakash, Y.S. J. Physiol. (Lond.) (2001) [Pubmed]
  23. Sevoflurane but not propofol preserves myocardial function in coronary surgery patients. De Hert, S.G., ten Broecke, P.W., Mertens, E., Van Sommeren, E.W., De Blier, I.G., Stockman, B.A., Rodrigus, I.E. Anesthesiology (2002) [Pubmed]
  24. Effects of sevoflurane on the intracellular Ca2+ transient in ferret cardiac muscle. Bartunek, A.E., Housmans, P.R. Anesthesiology (2000) [Pubmed]
  25. An isothermal titration calorimetry study on the binding of four volatile general anesthetics to the hydrophobic core of a four-alpha-helix bundle protein. Zhang, T., Johansson, J.S. Biophys. J. (2003) [Pubmed]
  26. Quantitative determination of vapor-phase compound A in sevoflurane anesthesia using gas chromatography-mass spectrometry. Bouche, M.P., Van Bocxlaer, J.F., Rolly, G., Versichelen, L.F., Struys, M.M., Mortier, E., De Leenheer, A.P. Clin. Chem. (2001) [Pubmed]
  27. Propofol and sevoflurane depress spinal neurons in vitro via different molecular targets. Grasshoff, C., Antkowiak, B. Anesthesiology (2004) [Pubmed]
  28. Opioid-volatile anesthetic synergy: a response surface model with remifentanil and sevoflurane as prototypes. Manyam, S.C., Gupta, D.K., Johnson, K.B., White, J.L., Pace, N.L., Westenskow, D.R., Egan, T.D. Anesthesiology (2006) [Pubmed]
  29. Inhibition of cytochrome P450 2E1 by propofol in human and porcine liver microsomes. Lejus, C., Fautrel, A., Mallédant, Y., Guillouzo, A. Biochem. Pharmacol. (2002) [Pubmed]
  30. Volatile anesthetics induce caspase-dependent, mitochondria-mediated apoptosis in human T lymphocytes in vitro. Loop, T., Dovi-Akue, D., Frick, M., Roesslein, M., Egger, L., Humar, M., Hoetzel, A., Schmidt, R., Borner, C., Pahl, H.L., Geiger, K.K., Pannen, B.H. Anesthesiology (2005) [Pubmed]
  31. Sevoflurane anaesthesia causes a transient decrease in aquaporin-2 and impairment of urine concentration. Morita, K., Otsuka, F., Ogura, T., Takeuchi, M., Mizobuchi, S., Yamauchi, T., Makino, H., Hirakawa, M. British journal of anaesthesia. (1999) [Pubmed]
  32. The inhibitory effects of sevoflurane on angiotensin II- induced, p44/42 mitogen-activated protein kinase-mediated contraction of rat aortic smooth muscle. Yu, J., Mizumoto, K., Tokinaga, Y., Ogawa, K., Hatano, Y. Anesth. Analg. (2005) [Pubmed]
  33. Sevoflurane inhibits phorbol-myristate-acetate-induced activator protein-1 activation in human T lymphocytes in vitro: potential role of the p38-stress kinase pathway. Loop, T., Scheiermann, P., Doviakue, D., Musshoff, F., Humar, M., Roesslein, M., Hoetzel, A., Schmidt, R., Madea, B., Geiger, K.K., Pahl, H.L., Pannen, B.H. Anesthesiology (2004) [Pubmed]
  34. Spectrum and subcellular determinants of fluorinated anesthetic-mediated proximal tubular injury. Lochhead, K.M., Kharasch, E.D., Zager, R.A. Am. J. Pathol. (1997) [Pubmed]
  35. Area under the plasma concentration-time curve of inorganic fluoride following sevoflurane anesthesia correlates with CYP2E1 mRNA level in mononuclear cells. Hase, I., Imaoka, S., Oda, Y., Hiroi, T., Nakamoto, T., Asada, A., Funae, Y. Anesthesiology (2000) [Pubmed]
  36. Effect of N2O on sevoflurane vaporizer settings during minimal- and low-flow anesthesia. Hendrickx, J.F., Coddens, J., Callebaut, F., Artico, H., Deloof, T., Demeyer, I., De Wolf, A.M. Anesthesiology (2002) [Pubmed]
  37. Influence of nitrous oxide on minimum alveolar concentration of sevoflurane for laryngeal mask insertion in children. Kihara, S., Yaguchi, Y., Inomata, S., Watanabe, S., Brimacombe, J.R., Taguchi, N., Komatsuzaki, T. Anesthesiology (2003) [Pubmed]
  38. Electroencephalographic derivatives as a tool for predicting the depth of sedation and anesthesia induced by sevoflurane. Katoh, T., Suzuki, A., Ikeda, K. Anesthesiology (1998) [Pubmed]
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