Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Hwu, W.J. et al.

Hwu, Krown, Menell, Panageas, Merrell, Lamb, Williams, Quinn, Foster, Chapman, Livingston, Wolchok, Houghton,

Phase II study of temozolomide plus thalidomide for the treatment of metastatic melanoma.

PURPOSE: To further investigate the efficacy and safety of temozolomide plus thalidomide in patients with metastatic melanoma without brain metastases. PATIENTS AND METHODS: Patients with histologically confirmed advanced-stage metastatic melanoma were enrolled in an open-label, phase II study. The primary end point was response rate. Patients received temozolomide (75 mg/m2/d x 6 weeks with a 2-week rest between cycles) plus concomitant thalidomide (200 mg/d with dose escalation to 400 mg/d for patients < 70 years old, or 100 mg/d with dose escalation to 250 mg/d for patients >/= 70 years old). Treatment was continued until unacceptable toxicity or disease progression occurred. RESULTS: Thirty-eight patients (median age, 62 years) with stage IV (three patients with M1a, eight with M1b, and 26 with M1c) or stage IIIc (one patient) melanoma and a median of four metastatic sites were enrolled, and received a median of two cycles of therapy. Twelve patients (32%) had an objective tumor response, including one with an ongoing complete response of 25+ months' duration and 11 with partial responses. Five patients achieving partial response with a more than 90% reduction of disease were converted to a complete response with surgery. Treatment was generally well tolerated. Median survival was 9.5 months (95% confidence interval, 6.05 to 19.38 months), with a median follow-up among survivors of 24.3 months. CONCLUSION: The combination of temozolomide plus thalidomide seems to be a promising and well-tolerated oral regimen for metastatic melanoma that merits further study.[1]

References

Phase II study of temozolomide plus thalidomide for the treatment of metastatic melanoma. Hwu, W.J., Krown, S.E., Menell, J.H., Panageas, K.S., Merrell, J., Lamb, L.A., Williams, L.J., Quinn, C.J., Foster, T., Chapman, P.B., Livingston, P.O., Wolchok, J.D., Houghton, A.N. J. Clin. Oncol. (2003) [Pubmed]

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