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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3.

A total of 116,118 basepairs (bp) derived from three cosmids spanning the ERCC1 locus of human chromosome 19q13.3 have been sequenced with automated fluorescence-based sequencers and analysed by polymerase chain reaction amplification and computer methods. The assembled sequence forms two contigs totalling 105,831 bp, which contain a human fosB proto-oncogene, a gene encoding a protein phosphatase, two genes of unknown function and the previously-characterized ERCC1 DNA repair gene. This light band region has a high average density of 1.4 Alu repeats per kilobase. Human chromosome light bands could therefore contain up to 75,000 genes and 1.5 million Alu repeats.[1]


  1. Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3. Martin-Gallardo, A., McCombie, W.R., Gocayne, J.D., FitzGerald, M.G., Wallace, S., Lee, B.M., Lamerdin, J., Trapp, S., Kelley, J.M., Liu, L.I. Nat. Genet. (1992) [Pubmed]
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