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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Increased frequency of 2,4,6-trinitrophenyl (TNP)-specific, H-2b-restricted cytotoxic T lymphocyte precursors in transgenic mice expressing a T cell receptor beta chain gene from an H-2b-restricted, TNP-specific cytolytic T cell clone.

T cell antigen receptors (TcR) expressing V alpha 10/J alpha BBM142 genes in association with beta chains containing J beta 2.6 elements were found to be predominant among 2,4,6-trinitrophenyl (TNP)-specific, H-2b-restricted cytolytic T cell lines (CTL). To assess the relative contribution of the TcR beta chain to the TNP specificity as well as to the selection of the respective TcR alpha chain elements we generated transgenic mice expressing the TcR beta chain of the H-2b/TNP-specific CTL clone BT7.4. 1. The TcR of this clone does not belong to the type predominant among H-2b/TNP-specific CTL, as it consists of an alpha chain encoded by a V alpha 8/J alpha DO gene rearrangement and a V beta 2/J beta 1.1-containing beta chain. In the transgenic mice almost all T cells exclusively express the transgenic V beta 2 gene, as a result of allelic exclusion. TNP-specific, H-2b-restricted precursors were found at 7- to 8-fold higher frequency in these mice as compared with non-transgenic littermates. In H-2b/d heterozygous transgenic mice, an increased frequency of TNP-specific precursors was found only in H-2b, but not in H-2d-restricted CTL. Analysis of H-2b/TNP-specific CTL lines derived from V beta 2-transgenic mice indicated a preferential association of the transgenic TcR beta chain with endogenous alpha chains encoded by V alpha 8 and J alpha BBM142 genes. This suggests that the hapten TNP is recognized like typical peptide antigens by combinatorial TcR alpha and beta contact sites.[1]


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