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Chemical Compound Review

Melinite     2,4,6-trinitrophenol

Synonyms: Picral, picric, Pikrinezuur, Pikrinsaeure, Trinitrophenol, ...
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Disease relevance of picric acid


Psychiatry related information on picric acid

  • The responses to 2,4,6-trinitrophenyl conjugates of different Ficoll preparations differ with respect to the magnitude of the accompanying auto-anti-idiotype (Id) response in both mice and chickens [6].

High impact information on picric acid


Chemical compound and disease context of picric acid


Biological context of picric acid


Anatomical context of picric acid


Associations of picric acid with other chemical compounds

  • Simultaneous injection of 2 X 10(7) gamma-irradiated or glutaraldehyde-fixed RCS cells with the antigen sheep red blood cells (SRBC) or 2,4,6-trinitrophenol (TNP)-Ficoll markedly suppressed the subsequent plaque-forming cell response in the spleen [27].
  • This high-resolution analysis indicates that the active site is partially occupied with picric acid and that the anomalous density seen in the original study is attributed to the population of multiple conformational states of Trp-102 and not a formal covalent bond between the indole ring of Trp-102 and picric acid [21].
  • The kinetics of responses to bacterial lipopolysaccharide (LPS) in both B cell subpopulations were determined in three assay procedures: 1) incorporation of radioactive thymidine into DNA; 2) incorporation of radioactive leucine into immunoglobulin; 3) enumeration of cells forming polyclonal antibody to the 2,4,6-trinitrophenyl hapten [28].
  • The low-melting polymorphic modification of the 1:1 complex of benzocaine (BC) and picric acid (PA) had earlier been reported to be an example of a "disappearing polymorph". The BC:PA system has been reinvestigated by thermomicroscopy, calorimetry, solid-state NMR, and X-ray crystallography [29].
  • A similar result was obtained when a monoclonal antibody directed against a single plasma membrane glycoprotein was used, or when the rate of surface loss of TNP groups unoccupied by antibodies was measured [30].

Gene context of picric acid


Analytical, diagnostic and therapeutic context of picric acid


  1. In vitro and in vivo studies of a 2,4,6-trinitrophenyl (TNP)-binding immunoglobulin A (IgA) lymphoma isolated from MOPC-315, a TNP-binding IgA plasmacytoma of BALB/c mice. Gebel, H.M., Autry, J.R., Rohrer, J.W., Lynch, R.G. J. Natl. Cancer Inst. (1979) [Pubmed]
  2. Direct thymic involvement in anterior chamber-associated immune deviation: evidence for a nondeletional mechanism of centrally induced tolerance to extrathymic antigens in adult mice. Wang, Y., Goldschneider, I., Foss, D., Wu, D.Y., O'Rourke, J., Cone, R.E. J. Immunol. (1997) [Pubmed]
  3. TGF-beta production regulates the development of the 2,4,6-trinitrophenol-conjugated keyhole limpet hemocyanin-induced colonic inflammation in IL-2-deficient mice. Lúdvíksson, B.R., Ehrhardt, R.O., Strober, W. J. Immunol. (1997) [Pubmed]
  4. Formation of lipid-linked oligosaccharides by MOPC 315 plasmacytoma cells. Decreased synthesis by a nonsecretory variant. Hickman, S., Wong-Yip, Y.P., Rebbe, N.F., Greco, J.M. J. Biol. Chem. (1985) [Pubmed]
  5. Protective immunity to progressive tumors can be induced by antigen presented on regressor tumors. Flood, P.M., Schreiber, H., Ron, Y. J. Immunol. (1987) [Pubmed]
  6. Production of auto-anti-idiotype antibody during the normal immune response. XI. Ficoll-induced variations in auto-anti-idiotype production during the response to 2,4,6-trinitrophenyl-Ficoll. Bhogal, B.S., Goidl, E.A., Jacobson, E.B., Gibbons, J.J., Thorbecke, G.J., Siskind, G.W. Cell. Immunol. (1985) [Pubmed]
  7. Dominance of one T-cell receptor in the H-2Kb/TNP response. Hochgeschwender, U., Simon, H.G., Weltzien, H.U., Bartels, F., Becker, A., Epplen, J.T. Nature (1987) [Pubmed]
  8. Self-MHC-restricted cytotoxic T-cell response without thymic influence. Ando, I. Nature (1981) [Pubmed]
  9. Production of target-specific effector cells using hetero-cross-linked aggregates containing anti-target cell and anti-Fc gamma receptor antibodies. Karpovsky, B., Titus, J.A., Stephany, D.A., Segal, D.M. J. Exp. Med. (1984) [Pubmed]
  10. Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. Rock, K.L., Benacerraf, B., Abbas, A.K. J. Exp. Med. (1984) [Pubmed]
  11. Definition of conditions that enable antigen-specific activation of the majority of isolated trinitrophenol-binding B cells. Cambier, J.C., Monroe, J.G., Neale, M.J. J. Exp. Med. (1982) [Pubmed]
  12. Initial hydrogenation during catabolism of picric acid by Rhodococcus erythropolis HL 24-2. Lenke, H., Knackmuss, H.J. Appl. Environ. Microbiol. (1992) [Pubmed]
  13. Conversion of 2,4,6-trinitrophenol to a mutagen by Pseudomonas aeruginosa. Wyman, J.F., Guard, H.E., Won, W.D., Quay, J.H. Appl. Environ. Microbiol. (1979) [Pubmed]
  14. Regulatory cells induced by feeding TNP-haptenated colonic protein cross-protect mice from colitis induced by an unrelated hapten. Boirivant, M., Strober, W., Fuss, I.J. Inflamm. Bowel Dis. (2005) [Pubmed]
  15. A primary in vitro antibody assay for antigen-specific T-suppressor factor: cross-suppression of TNP-specific antibody responses by TMA-specific TsF1. Jendrisak, G.S., Jayaraman, S., Bellone, C.J. Cell. Immunol. (1985) [Pubmed]
  16. Immunocytochemical diagnosis of early myocardial ischaemic/hypoxic damage. Leadbeatter, S., Wawman, H.M., Jasani, B. Forensic Sci. Int. (1989) [Pubmed]
  17. Effect of colchicine on the antibody response. I. Enhancement of antibody formation in mice. Shek, P.N., Coons, A.H. J. Exp. Med. (1978) [Pubmed]
  18. Stimulation and inhibition of secretion in Paramecium: role of divalent cations. Gilligan, D.M., Satir, B.H. J. Cell Biol. (1983) [Pubmed]
  19. Regulation of the systemic immune response by visible light and the eye. Ferguson, T.A., Hayashi, J.D., Kaplan, H.J. FASEB J. (1988) [Pubmed]
  20. Bioelimination of trinitroaromatic compounds: immobilization versus mineralization. Heiss, G., Knackmuss, H.J. Curr. Opin. Microbiol. (2002) [Pubmed]
  21. Atomic resolution structures and solution behavior of enzyme-substrate complexes of Enterobacter cloacae PB2 pentaerythritol tetranitrate reductase. Multiple conformational states and implications for the mechanism of nitroaromatic explosive degradation. Khan, H., Barna, T., Harris, R.J., Bruce, N.C., Barsukov, I., Munro, A.W., Moody, P.C., Scrutton, N.S. J. Biol. Chem. (2004) [Pubmed]
  22. Preferential expression of a defined T-cell receptor beta-chain gene in hapten-specific cytotoxic T-cell clones. Hochgeschwender, U., Weltzien, H.U., Eichmann, K., Wallace, R.B., Epplen, J.T. Nature (1986) [Pubmed]
  23. Dendritic cells are accessory cells for the development of anti-trinitrophenyl cytotoxic T lymphocytes. Nussenzweig, M.C., Steinman, R.M., Gutchinov, B., Cohn, Z.A. J. Exp. Med. (1980) [Pubmed]
  24. The role of H-2 linked genes in helper T-cell function. IV. Importance of T-cell genotype and host environment in I-region and Ir gene expression. Kappler, J.W., Marrack, P. J. Exp. Med. (1978) [Pubmed]
  25. Immunoglobulin heavy chain constant regions regulate immunity and tolerance to idiotypes of antibody variable regions. Reitan, S.K., Hannestad, K. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  26. Introduction of antigenic phospholipids into the plasma membrane of mammalian cells: organization and antibody-induced lipid redistribution. Schroit, A.J., Pagano, R.E. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  27. Regulation of immune responses in SJL and F1 hybrid mice by gamma-irradiated syngeneic lymphoma cells. Katz, I.R., Nagase, F., Bell, M.K., Ponzio, N.M., Thorbecke, G.J. J. Natl. Cancer Inst. (1984) [Pubmed]
  28. Polyclonal activation of CR+ and CR- B lymphocytes: the kinetics of initiation of DNA and immunoglobulin synthesis by lipopolysaccharide. Hämmerling, U., Chua, R., Hoffmann, M.K. J. Immunol. (1978) [Pubmed]
  29. Disappearing and reappearing polymorphs. The benzocaine:picric acid system. Henck, J.O., Bernstein, J., Ellern, A., Boese, R. J. Am. Chem. Soc. (2001) [Pubmed]
  30. Cell surface glycoproteins of CHO cells. I. Internalization and rapid recycling. Raub, T.J., Denny, J.B., Roberts, R.M. Exp. Cell Res. (1986) [Pubmed]
  31. CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. Castigli, E., Alt, F.W., Davidson, L., Bottaro, A., Mizoguchi, E., Bhan, A.K., Geha, R.S. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  32. Regulation of Fas ligand-induced apoptosis by TNF. Elzey, B.D., Griffith, T.S., Herndon, J.M., Barreiro, R., Tschopp, J., Ferguson, T.A. J. Immunol. (2001) [Pubmed]
  33. No role of interleukin-4 in CD23/IgE-mediated enhancement of the murine antibody response in vivo. Hjulström, S., Landin, A., Jansson, L., Holmdahl, R., Heyman, B. Eur. J. Immunol. (1995) [Pubmed]
  34. Dysregulated intrathymic development in the IL-2-deficient mouse leads to colitis-inducing thymocytes. Lúdvíksson, B.R., Gray, B., Strober, W., Ehrhardt, R.O. J. Immunol. (1997) [Pubmed]
  35. Characterization of the interleukin 5-reactive splenic B cell population. Rolink, A.G., Thalmann, P., Kikuchi, Y., Erdei, A. Eur. J. Immunol. (1990) [Pubmed]
  36. Apoptosis, tolerance, and regulatory T cells--old wine, new wineskins. Ferguson, T.A., Stuart, P.M., Herndon, J.M., Griffith, T.S. Immunol. Rev. (2003) [Pubmed]
  37. A simplified method for HPLC determination of creatinine in mouse serum. Yuen, P.S., Dunn, S.R., Miyaji, T., Yasuda, H., Sharma, K., Star, R.A. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  38. Effect of interleukin 1 on the induction and maintenance of B cell tolerance in vitro. Duan, J.M., Habicht, G.S. J. Leukoc. Biol. (1989) [Pubmed]
  39. Inhibitory mechanisms of antibody production by nitrogen oxides released from activated macrophages during the immune response: relationship to energy consumption. Takagi, K., Nukaya, I., Yasukawa, K., Suketa, Y. Immunol. Cell Biol. (1994) [Pubmed]
  40. Diesel exhaust, carbon black, and silica particles display distinct Th1/Th2 modulating activity. van Zijverden, M., van der Pijl, A., Bol, M., van Pinxteren, F.A., de Haar, C., Penninks, A.H., van Loveren, H., Pieters, R. Toxicol. Appl. Pharmacol. (2000) [Pubmed]
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