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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Region-specific expression of a K+ channel gene in brain.

Northern blot analysis and in situ hybridization studies reveal the highly localized expression in rat brain of transcripts from a gene (KShIIIA) encoding components for voltage-gated K+ channels. KShIIIA expression is particularly prominent throughout the dorsal thalamus. The expression of KShIIIA is compared to that of a closely related gene, here called NGK2-KV4. These two genes encode transcripts that induce currents in Xenopus oocytes that are as of yet indistinguishable, but they show very different patterns of expression in rat brain. NGK2-KV4 transcripts are particularly abundant in the cerebellar cortex, where KShIIIA expression is very weak. These results demonstrate the existence of cell-type-specific K+ channel components and suggest that one reason for the unusually large diversity of K+ channel proteins is the presence of subtypes that participate in specific brain functions.[1]


  1. Region-specific expression of a K+ channel gene in brain. Rudy, B., Kentros, C., Weiser, M., Fruhling, D., Serodio, P., Vega-Saenz de Miera, E., Ellisman, M.H., Pollock, J.A., Baker, H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
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