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Debec, A. et al.

Cyclin B is associated with centrosomes in Drosophila mitotic cells.

We have studied by way of confocal laser scanning microscopy the subcellular localization of cyclin B in Drosophila-cultured cells and report here evidence that a part of the cyclin B cell pool is closely associated with the centrosome. This cyclin B centrosomal signal is strong in prophase and metaphase but disappears during anaphase. Moreover, the signal is absent in the acentriolar Drosophila cell line 1182-4. These results put forward additional arguments suggesting that the centrosome plays an important role in the control of the cell cycle.[1]

References

Cyclin B is associated with centrosomes in Drosophila mitotic cells. Debec, A., Montmory, C. Biol. Cell (1992) [Pubmed]

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