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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The modifier subunit of glutamate cysteine ligase (GCLM) is a molecular target for amelioration of cisplatin resistance in lung cancer.

It is unclear whether a subunit of glutamate cysteine ligase [a modifier subunit (GCLM) and a catalytic subunit (GCLC)] is an effective target for ameliorating cisplatin (CDDP)-resistance. We inhibited each subunit of GCL mRNA using a specific ribozyme (M-Rz and C-Rz) in the pulmonary adenocarcinoma cell line A549. GCL activity was suppressed by the ribozyme. CDDP-resistance was more effectively ameliorated when GCLM rather than GCLC was inhibited. GCLM is a potentially more effective pharmacologic target for ameliorating CDDP-resistance in non-small cell lung cancer than GCLC.[1]

References

  1. The modifier subunit of glutamate cysteine ligase (GCLM) is a molecular target for amelioration of cisplatin resistance in lung cancer. Inoue, Y., Tomisawa, M., Yamazaki, H., Abe, Y., Suemizu, H., Tsukamoto, H., Tomii, Y., Kawamura, M., Kijima, H., Hatanaka, H., Ueyama, Y., Nakamura, M., Kobayashi, K. Int. J. Oncol. (2003) [Pubmed]
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