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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The TRAIL to arthritis.

Antigen-specific lymphocytes are involved in synovial proliferation within inflamed joints. Activated lymphocytes and synoviocytes from patients with rheumatoid arthritis express receptors that can bind TNF-related apoptosis-inducing ligand (TRAIL). A new study demonstrates that DCs pulsed with collagen and transduced with an adenovirus-based vector able to express TRAIL limit the incidence of arthritis in a model of collagen-induced arthritis and joint inflammation. These results suggest that gene-modified cell therapy represents a therapeutic option for systemic rheumatic diseases.[1]


  1. The TRAIL to arthritis. Tsokos, G.C., Tsokos, M. J. Clin. Invest. (2003) [Pubmed]
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