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Gene Review

Tnfsf10  -  tumor necrosis factor (ligand) superfamily...

Mus musculus

Synonyms: A330042I21Rik, AI448571, APO-2L, Ly81, Protein TRAIL, ...
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Disease relevance of Tnfsf10


High impact information on Tnfsf10

  • RIP is also required for necrotic death induced by tumor necrosis factor (TNF) and TNF-related apoptosis-inducing ligand (TRAIL) [5].
  • VSMCs sensitive to T cell-mediated killing express the death receptor DR5 (TNF-related apoptosis-inducing ligand [TRAIL] receptor 2), and anti-TRAIL and anti-DR5 antibodies block T cell-mediated apoptosis [6].
  • A combination of TUNEL and immunostaining for death-inducing tumor necrosis factor (TNF) family molecules indicated that the apoptotic cells were frequently found in conjugation with TNF-related apoptosis-inducing ligand (TRAIL)-expressing CD3+CD4+ human T cells [7].
  • Activated lymphocytes and synoviocytes from patients with rheumatoid arthritis express receptors that can bind TNF-related apoptosis-inducing ligand (TRAIL) [8].
  • In contrast, no difference in apoptosis is observed between cultured K8-null and WT hepatocytes after addition of the Fas-related death-factors tumor necrosis factor (TNF) alpha or TNF-related apoptosis-inducing ligand [9].

Chemical compound and disease context of Tnfsf10


Biological context of Tnfsf10


Anatomical context of Tnfsf10

  • In this study, we have investigated the effect of TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily of cytokines, in osteoclastogenesis, by using human peripheral blood mononuclear cells and the RAW264.7 murine monocytic cell line [16].
  • Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells [17].
  • We show that exposure to LF 15-0195 sensitizes Jurkat T cells to apoptosis induced by an agonistic anti-CD95 antibody (CH11 clone) and by the cytokine TNF-related apoptosis-inducing ligand [18].
  • Using stably transfected mouse TOSO (mTOSO)-expressing Jurkat cells, we show that TOSO protects cells from Fas/Fas ligand- and tumor necrosis factor-induced apoptosis but not from TNF-related apoptosis-inducing ligand-induced apoptosis [19].
  • Interferon gamma and lipopolysaccharide upregulate TNF-related apoptosis-inducing ligand expression in murine microglia [20].

Regulatory relationships of Tnfsf10


Other interactions of Tnfsf10


Analytical, diagnostic and therapeutic context of Tnfsf10


  1. Adenoviral expression of XIAP antisense RNA induces apoptosis in glioma cells and suppresses the growth of xenografts in nude mice. Naumann, U., B??hr, O., Wolburg, H., Altenberend, S., Wick, W., Liston, P., Ashkenazi, A., Weller, M. Gene Ther. (2007) [Pubmed]
  2. TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L suppresses experimental autoimmune encephalomyelitis in mice. Cretney, E., McQualter, J.L., Kayagaki, N., Yagita, H., Bernard, C.C., Grewal, I.S., Ashkenazi, A., Smyth, M.J. Immunol. Cell Biol. (2005) [Pubmed]
  3. Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice. Cretney, E., Takeda, K., Yagita, H., Glaccum, M., Peschon, J.J., Smyth, M.J. J. Immunol. (2002) [Pubmed]
  4. Interferon-gamma and TRAIL in human breast tumor cells. Ruiz de Almodóvar, C., López-Rivas, A., Ruiz-Ruiz, C. Vitam. Horm. (2004) [Pubmed]
  5. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Holler, N., Zaru, R., Micheau, O., Thome, M., Attinger, A., Valitutti, S., Bodmer, J.L., Schneider, P., Seed, B., Tschopp, J. Nat. Immunol. (2000) [Pubmed]
  6. TRAIL-expressing T cells induce apoptosis of vascular smooth muscle cells in the atherosclerotic plaque. Sato, K., Niessner, A., Kopecky, S.L., Frye, R.L., Goronzy, J.J., Weyand, C.M. J. Exp. Med. (2006) [Pubmed]
  7. Critical contribution of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to apoptosis of human CD4+ T cells in HIV-1-infected hu-PBL-NOD-SCID mice. Miura, Y., Misawa, N., Maeda, N., Inagaki, Y., Tanaka, Y., Ito, M., Kayagaki, N., Yamamoto, N., Yagita, H., Mizusawa, H., Koyanagi, Y. J. Exp. Med. (2001) [Pubmed]
  8. The TRAIL to arthritis. Tsokos, G.C., Tsokos, M. J. Clin. Invest. (2003) [Pubmed]
  9. Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation. Gilbert, S., Loranger, A., Daigle, N., Marceau, N. J. Cell Biol. (2001) [Pubmed]
  10. Cisplatin-dependent upregulation of death receptors 4 and 5 augments induction of apoptosis by TNF-related apoptosis-inducing ligand against esophageal squamous cell carcinoma. Kondo, K., Yamasaki, S., Sugie, T., Teratani, N., Kan, T., Imamura, M., Shimada, Y. Int. J. Cancer (2006) [Pubmed]
  11. Cloning, sequencing, and functional characterization of the rat homologue of receptor activator of NF-kappaB ligand. Xu, J., Tan, J.W., Huang, L., Gao, X.H., Laird, R., Liu, D., Wysocki, S., Zheng, M.H. J. Bone Miner. Res. (2000) [Pubmed]
  12. Defined inflammatory states in astrocyte cultures: correlation with susceptibility towards CD95-driven apoptosis. Falsig, J., Latta, M., Leist, M. J. Neurochem. (2004) [Pubmed]
  13. Suppression of antibody production by TNF-related apoptosis-inducing ligand (TRAIL). Kayagaki, N., Yamaguchi, N., Abe, M., Hirose, S., Shirai, T., Okumura, K., Yagita, H. Cell. Immunol. (2002) [Pubmed]
  14. Tumor-infiltrating CD4+ T lymphocytes express APO2 ligand (APO2L)/TRAIL upon specific stimulation with autologous lung carcinoma cells: role of IFN-alpha on APO2L/TRAIL expression and -mediated cytotoxicity. Dorothée, G., Vergnon, I., Menez, J., Echchakir, H., Grunenwald, D., Kubin, M., Chouaib, S., Mami-Chouaib, F. J. Immunol. (2002) [Pubmed]
  15. A "stealth effect": adenocarcinoma cells engineered to express TRAIL elude tumor-specific and allogeneic T cell reactions. Giovarelli, M., Musiani, P., Garotta, G., Ebner, R., Di Carlo, E., Kim, Y., Cappello, P., Rigamonti, L., Bernabei, P., Novelli, F., Modesti, A., Coletti, A., Ferrie, A.K., Lollini, P.L., Ruben, S., Salcedo, T., Forni, G. J. Immunol. (1999) [Pubmed]
  16. TNF-related apoptosis-inducing ligand (TRAIL) blocks osteoclastic differentiation induced by RANKL plus M-CSF. Zauli, G., Rimondi, E., Nicolin, V., Melloni, E., Celeghini, C., Secchiero, P. Blood (2004) [Pubmed]
  17. Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells. Kayagaki, N., Yamaguchi, N., Nakayama, M., Takeda, K., Akiba, H., Tsutsui, H., Okamura, H., Nakanishi, K., Okumura, K., Yagita, H. J. Immunol. (1999) [Pubmed]
  18. LF 15-0195 immunosuppressive agent enhances activation-induced T-cell death by facilitating caspase-8 and caspase-10 activation at the DISC level. Ducoroy, P., Micheau, O., Perruche, S., Dubrez-Daloz, L., de Fornel, D., Dutartre, P., Saas, P., Solary, E. Blood (2003) [Pubmed]
  19. The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain. Song, Y., Jacob, C.O. J. Biol. Chem. (2005) [Pubmed]
  20. Interferon gamma and lipopolysaccharide upregulate TNF-related apoptosis-inducing ligand expression in murine microglia. Genc, S., Kizildag, S., Genc, K., Ates, H., Atabey, N., Kizyldag, S. Immunol. Lett. (2003) [Pubmed]
  21. Anti-human hepatocellular carcinoma effects of tumor necrosis factor-related apoptosis-inducing ligand in vitro & in vivo. Guo, B.C., Xu, Y.H. Acta Pharmacol. Sin. (2001) [Pubmed]
  22. Immortalized myeloid suppressor cells trigger apoptosis in antigen-activated T lymphocytes. Apolloni, E., Bronte, V., Mazzoni, A., Serafini, P., Cabrelle, A., Segal, D.M., Young, H.A., Zanovello, P. J. Immunol. (2000) [Pubmed]
  23. Gene expression analysis on the dicyclanil-induced hepatocellular tumors in mice. Moto, M., Okamura, M., Muguruma, M., Ito, T., Jin, M., Kashida, Y., Mitsumori, K. Toxicologic pathology (2006) [Pubmed]
  24. Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells. Tan, K.B., Harrop, J., Reddy, M., Young, P., Terrett, J., Emery, J., Moore, G., Truneh, A. Gene (1997) [Pubmed]
  25. Maternal diabetes adversely affects preovulatory oocyte maturation, development, and granulosa cell apoptosis. Chang, A.S., Dale, A.N., Moley, K.H. Endocrinology (2005) [Pubmed]
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