The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Rheumatic Diseases

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Rheumatic Diseases


Psychiatry related information on Rheumatic Diseases


High impact information on Rheumatic Diseases

  • Our structural observations, supported by mutation studies of both La and RNA components, illustrate the principles behind RNA sequestration by a rheumatic disease autoantigen, whereby the UUU(OH) 3' ends of nascent RNA transcripts are protected during downstream processing and maturation events [8].
  • Autoantibodies from patients with systemic rheumatic diseases were used to map antigenic sites on the 68-kD autoantigen (p68) associated with (U1)RNA-containing small nuclear ribonucleoprotein (snRNP) particles [9].
  • Furthermore, the sera from a subgroup of patients with other rheumatic diseases and a surprisingly high percentage of asymptomatic relatives of SLE patients exhibited a similar effect [10].
  • The rheumatic disease autoantigen, Ro/SSA, was immunogenic to a rabbit host [11].
  • Here we show that DNA-containing immune complexes (ICs) within lupus serum (SLE-ICs), but not protein-containing ICs from other autoimmune rheumatic diseases, stimulates plasmacytoid DCs (PDCs) to produce cytokines and chemokines via a cooperative interaction between Toll-like receptor 9 (TLR9) and FcgammaRIIa (CD32) [12].

Chemical compound and disease context of Rheumatic Diseases


Biological context of Rheumatic Diseases


Anatomical context of Rheumatic Diseases


Gene context of Rheumatic Diseases


Analytical, diagnostic and therapeutic context of Rheumatic Diseases


  1. Influenza vaccination in patients with rheumatic diseases. Safety and efficacy. Herron, A., Dettleff, G., Hixon, B., Brandwin, L., Ortbals, D., Hornick, R., Hahn, B. JAMA (1979) [Pubmed]
  2. Characterization of a distinct nuclear acidic protein antigen (MA) and clinical findings in systemic lupus erythematosus patients with MA antibodies. Winn, D.M., Wolfe, J.F., Harmon, D., Sharp, G.C. J. Clin. Invest. (1979) [Pubmed]
  3. Ocular toxicity and antenatal exposure to chloroquine or hydroxychloroquine for rheumatic diseases. Klinger, G., Morad, Y., Westall, C.A., Laskin, C., Spitzer, K.A., Koren, G., Ito, S., Buncic, R.J. Lancet (2001) [Pubmed]
  4. Molecular cloning of a cDNA encoding the human Sm-D autoantigen. Rokeach, L.A., Haselby, J.A., Hoch, S.O. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  5. Spontaneous regression of lymphoproliferative disorders in patients treated with methotrexate for rheumatoid arthritis and other rheumatic diseases. Salloum, E., Cooper, D.L., Howe, G., Lacy, J., Tallini, G., Crouch, J., Schultz, M., Murren, J. J. Clin. Oncol. (1996) [Pubmed]
  6. Medical complications of cocaine and other illicit drug abuse simulating rheumatic disease. Lie, J.T. J. Rheumatol. (1990) [Pubmed]
  7. Rheumatic manifestations of neurologic and psychiatric diseases. Aviña-Zubieta, J.A., Páez, F., Galindo-Rodriguez, G. Current opinion in rheumatology. (1997) [Pubmed]
  8. Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen. Teplova, M., Yuan, Y.R., Phan, A.T., Malinina, L., Ilin, S., Teplov, A., Patel, D.J. Mol. Cell (2006) [Pubmed]
  9. Human anti-p68 autoantibodies recognize a common epitope of U1 RNA containing small nuclear ribonucleoprotein and influenza B virus. Guldner, H.H., Netter, H.J., Szostecki, C., Jaeger, E., Will, H. J. Exp. Med. (1990) [Pubmed]
  10. DNA receptor dysfunction in systemic lupus erythematosus and kindred disorders. Induction by anti-DNA antibodies, antihistone antibodies, and antireceptor antibodies. Bennett, R.M., Kotzin, B.L., Merritt, M.J. J. Exp. Med. (1987) [Pubmed]
  11. The Ro/SSA autoantigen as an immunogen. Some anti-Ro/SSA antibody binds IgG. Mamula, M.J., Fox, O.F., Yamagata, H., Harley, J.B. J. Exp. Med. (1986) [Pubmed]
  12. Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. Means, T.K., Latz, E., Hayashi, F., Murali, M.R., Golenbock, D.T., Luster, A.D. J. Clin. Invest. (2005) [Pubmed]
  13. Detection and expression of a cDNA clone that encodes a polypeptide containing two inhibitory domains of human calpastatin and its recognition by rheumatoid arthritis sera. Després, N., Talbot, G., Plouffe, B., Boire, G., Ménard, H.A. J. Clin. Invest. (1995) [Pubmed]
  14. Chloroquine in rheumatic disease. Holt, P.J. Lancet (1979) [Pubmed]
  15. Protective effect of prostaglandin E2 in the gastrointestinal tract during indomethacin treatment of rheumatic diseases. Johansson, C., Kollberg, B., Nordemar, R., Samuelson, K., Bergström, S. Gastroenterology (1980) [Pubmed]
  16. Rheumatic disease, heavy-metal pigments, and the Great Masters. Pedersen, L.M., Permin, H. Lancet (1988) [Pubmed]
  17. Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine. Black, A.J., McLeod, H.L., Capell, H.A., Powrie, R.H., Matowe, L.K., Pritchard, S.C., Collie-Duguid, E.S., Reid, D.M. Ann. Intern. Med. (1998) [Pubmed]
  18. Cell-mediated immunity in rheumatic diseases. II. Mitogen responses in RA, SLE, and other illnesses: correlation with T- and B-lymphocyte populations. Lockshin, M.D., Eisenhauer, A.C., Kohn, R., Weksler, M., Block, S., Mushlin, S.B. Arthritis Rheum. (1975) [Pubmed]
  19. Murine graft vs host disease. A model for study of mechanisms that generate autoantibodies to ribonucleoproteins. Gelpi, C., Rodriguez-Sanchez, J.L., Martinez, M.A., Craft, J., Hardin, J.A. J. Immunol. (1988) [Pubmed]
  20. Beclomethasone dipropionate inhalation treatment for chronic hoarseness in rheumatic disease. Goldberg, J., Kovarsky, J. Arthritis Rheum. (1983) [Pubmed]
  21. Restriction fragment length polymorphism of the vitronectin gene in patients with rheumatic diseases. Shiokawa, S., Yasuda, M., Nobunaga, M. Arthritis Rheum. (1992) [Pubmed]
  22. Lymphocyte function in rheumatic disorders. Vaughan, J.H., Chihara, T. Arch. Intern. Med. (1975) [Pubmed]
  23. Synovial fluid lactic acid in septic and nonseptic arthritis. Arthur, R.E., Stern, M., Galeazzi, M., Baldassare, A.R., Weiss, T.D., Rogers, J.R., Zuckner, J. Arthritis Rheum. (1983) [Pubmed]
  24. The stress protein BiP is overexpressed and is a major B and T cell target in rheumatoid arthritis. Bläss, S., Union, A., Raymackers, J., Schumann, F., Ungethüm, U., Müller-Steinbach, S., De Keyser, F., Engel, J.M., Burmester, G.R. Arthritis Rheum. (2001) [Pubmed]
  25. Immunity to soluble retinal antigen in patients with uveitis accompanying juvenile rheumatoid arthritis. Petty, R.E., Hunt, D.W., Rollins, D.F., Schroeder, M.L., Puterman, M.L. Arthritis Rheum. (1987) [Pubmed]
  26. Serum levels of interleukin-2 receptor and activity of rheumatic diseases characterized by immune system activation. Campen, D.H., Horwitz, D.A., Quismorio, F.P., Ehresmann, G.R., Martin, W.J. Arthritis Rheum. (1988) [Pubmed]
  27. Autoantibody recognition of distinctly modified forms of the U1-70-kd antigen is associated with different clinical disease manifestations. Greidinger, E.L., Casciola-Rosen, L., Morris, S.M., Hoffman, R.W., Rosen, A. Arthritis Rheum. (2000) [Pubmed]
  28. BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases. Roschke, V., Sosnovtseva, S., Ward, C.D., Hong, J.S., Smith, R., Albert, V., Stohl, W., Baker, K.P., Ullrich, S., Nardelli, B., Hilbert, D.M., Migone, T.S. J. Immunol. (2002) [Pubmed]
  29. Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases. Cope, A.P., Aderka, D., Doherty, M., Engelmann, H., Gibbons, D., Jones, A.C., Brennan, F.M., Maini, R.N., Wallach, D., Feldmann, M. Arthritis Rheum. (1992) [Pubmed]
  30. Rheumatic diseases in an MRL strain of mice with a deficit in the functional Fas ligand. Ito, M.R., Terasaki, S., Itoh, J., Katoh, H., Yonehara, S., Nose, M. Arthritis Rheum. (1997) [Pubmed]
  31. Autoantibodies to lipoprotein lipase and dyslipidemia in systemic lupus erythematosus. Reichlin, M., Fesmire, J., Quintero-Del-Rio, A.I., Wolfson-Reichlin, M. Arthritis Rheum. (2002) [Pubmed]
  32. Cytokine profile in systemic lupus erythematosus, rheumatoid arthritis, and other rheumatic diseases. al-Janadi, M., al-Balla, S., al-Dalaan, A., Raziuddin, S. J. Clin. Immunol. (1993) [Pubmed]
  33. Human alpha-enolase from endothelial cells as a target antigen of anti-endothelial cell antibody in Behçet's disease. Lee, K.H., Chung, H.S., Kim, H.S., Oh, S.H., Ha, M.K., Baik, J.H., Lee, S., Bang, D. Arthritis Rheum. (2003) [Pubmed]
  34. Spectrum and clinical significance of autoantibodies against transfer RNA. Ohosone, Y., Ishida, M., Takahashi, Y., Matsumura, M., Hirakata, M., Kawahara, Y., Nishikawa, T., Mimori, T. Arthritis Rheum. (1998) [Pubmed]
  35. Quantitative radioligand assays using de novo-synthesized recombinant autoantigens in connective tissue diseases: new tools to approach the pathogenic significance of anti-RNP antibodies in rheumatic diseases. Yamamoto, A.M., Amoura, Z., Johannet, C., Jeronimo, A.L., Campos, H., Koutouzov, S., Piette, J.C., Bach, J.F. Arthritis Rheum. (2000) [Pubmed]
  36. Suppression of rheumatoid factor production by methotrexate in patients with rheumatoid arthritis. Evidence for differential influences of therapy and clinical status on IgM and IgA rheumatoid factor expression. Alarcón, G.S., Schrohenloher, R.E., Bartolucci, A.A., Ward, J.R., Williams, H.J., Koopman, W.J. Arthritis Rheum. (1990) [Pubmed]
  37. Plasmapheresis and lymphoplasmapheresis in the management of rheumatoid arthritis. Wallace, D.J., Goldfinger, D., Gatti, R., Lowe, C., Fan, P., Bluestone, R., Klinenberg, J.R. Arthritis Rheum. (1979) [Pubmed]
WikiGenes - Universities