Disease relevance of Rheumatic Diseases

• The safety and efficacy of influenza vaccination were studied in 32 healthy volunteers and in 62 patients with systemic lupus erythematosus (SLE), rheumatoid arthritis, degenerative joint disease, and other rheumatic diseases [1].
• MA antibodies were detected in the serum of 12 of 66 lupus patients and in none of 554 sera from normal controls or patients with other rheumatic diseases [2].
• Ocular toxicity and antenatal exposure to chloroquine or hydroxychloroquine for rheumatic diseases [3].
• Antibodies to the Sm-D polypeptide antigen are closely associated with the rheumatic disease systemic lupus erythematosus [4].
• Spontaneous regression of lymphoproliferative disorders in patients treated with methotrexate for rheumatoid arthritis and other rheumatic diseases [5].

Psychiatry related information on Rheumatic Diseases

• Medical complications of cocaine and other illicit drug abuse simulating rheumatic disease [6].
• The lower prevalence of rheumatoid arthritis in schizophrenia patients is mentioned, and a brief description is presented of somatoform disorders that may confound diagnosis with rheumatic diseases [7].

High impact information on Rheumatic Diseases

• Our structural observations, supported by mutation studies of both La and RNA components, illustrate the principles behind RNA sequestration by a rheumatic disease autoantigen, whereby the UUU(OH) 3' ends of nascent RNA transcripts are protected during downstream processing and maturation events [8].
• Autoantibodies from patients with systemic rheumatic diseases were used to map antigenic sites on the 68-kD autoantigen (p68) associated with (U1)RNA-containing small nuclear ribonucleoprotein (snRNP) particles [9].
• Furthermore, the sera from a subgroup of patients with other rheumatic diseases and a surprisingly high percentage of asymptomatic relatives of SLE patients exhibited a similar effect [10].
• The rheumatic disease autoantigen, Ro/SSA, was immunogenic to a rabbit host [11].
• Here we show that DNA-containing immune complexes (ICs) within lupus serum (SLE-ICs), but not protein-containing ICs from other autoimmune rheumatic diseases, stimulates plasmacytoid DCs (PDCs) to produce cytokines and chemokines via a cooperative interaction between Toll-like receptor 9 (TLR9) and FcgammaRIIa (CD32) [12].

Chemical compound and disease context of Rheumatic Diseases

• Calpastatin is the natural inhibitor of calpains, which are members of the cysteine proteinases recently implicated in joint destruction in rheumatic diseases [13].
• Chloroquine in rheumatic disease [14].
• The protective effect was studied in humans by measuring the fecal blood loss during indomethacin treatment of 18 patients with rheumatic diseases with and without concomitant oral supplementation with 1 mg prostaglandin E2 three times daily [15].
• These four painters may have been heavily exposed to mercury sulphide, cadmium sulphide, arsenic sulphide, lead, antimony, tin, cobalt, manganese, and chromium, the metals of the bright and clear colours, and exposure to these metals may be of importance in the development of inflammatory rheumatic diseases [16].
• PATIENTS: 67 patients for whom azathioprine was prescribed as second-line therapy for rheumatic disease [17].

Biological context of Rheumatic Diseases

• Cell-mediated immunity in rheumatic diseases. II. Mitogen responses in RA, SLE, and other illnesses: correlation with T- and B-lymphocyte populations [18].
• To determine whether these antibodies were directed against the small nuclear ribonucleoprotein (snRNP) particles that are characteristic targets for autoimmune responses in human rheumatic diseases, sera were studied in the 32P immunoprecipitation and immunoblotting assays [19].
• Beclomethasone dipropionate inhalation treatment for chronic hoarseness in rheumatic disease [20].
• Restriction fragment length polymorphism of the vitronectin gene in patients with rheumatic diseases [21].
• This review discusses the immunology of rheumatic diseases, specifically rheumatoid arthritis, and systemic lupus erythematosus, and presents some known data, while suggesting what more needs to be learned [22].

Anatomical context of Rheumatic Diseases

• We determined lactic acid levels by the lactic dehydrogenase method in synovial fluid of 41 patients with various rheumatic diseases, to test the concept that significantly elevated values were diagnostic of septic arthritis [23].
• In healthy individuals and patients with other rheumatic diseases, BiP-reactive T cells were undetectable [24].
• Studies of immunity to bovine soluble retinal antigen (antigen S) were carried out using serum and peripheral blood lymphocytes from children with juvenile rheumatoid arthritis and chronic anterior uveitis (JRA-uveitis), children with JRA alone, children with nonrheumatic diseases, and controls who had no ocular or rheumatic disease [25].
• Serum levels of interleukin-2 receptor and activity of rheumatic diseases characterized by immune system activation [26].
• METHODS: Blinded to clinical disease manifestations, sera from 27 rheumatic disease patients with U1-70-kd antibodies were used to immunoblot control, apoptotic, and oxidatively modified HeLa cell lysates [27].

Gene context of Rheumatic Diseases

• BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases [28].
• Biologically active soluble TNF-R are up-regulated in patients with rheumatic disease and are produced locally in the joints [29].
• CONCLUSION: Rheumatic disease was generated by the gld gene in mice with an MRL background, as it is by the lpr gene, which is a Fas deletion mutant, associated with autoimmune traits [30].
• METHOD: Binding of LPL by IgG from sera obtained from patients with SLE and other rheumatic diseases was measured by an enzyme-linked immunosorbent assay technique [31].
• Cytokine profile in systemic lupus erythematosus, rheumatoid arthritis, and other rheumatic diseases [32].

Analytical, diagnostic and therapeutic context of Rheumatic Diseases

• Western blotting and enzyme-linked immunosorbent assay (ELISA) of recombinant protein isolated by gene cloning were performed on serum from healthy controls, patients with BD, and patients with other rheumatic diseases (rheumatoid arthritis, systemic lupus erythematosus, and Wegener's granulomatosis) [33].
• METHODS: Sera from 1,472 patients with suspected systemic rheumatic disease were screened by RNA immunoprecipitation of HeLa cell extracts [34].
• CONCLUSION: These highly sensitive, specific, and quantitative RLAs represent new tools for the detection of autoantibodies to RNP antigens in rheumatic diseases, and may be useful for (differential) diagnosis in clinical practice [35].
• We determined IgM-RF and IgA-RF levels in paired serum samples (obtained at study entry and completion) from RA patients enrolled in multicenter trials with the Cooperative Systematic Studies of Rheumatic Diseases program [36].
• We have demonstrated the efficacy of therapeutic pheresis in a number of rheumatic diseases, especially rheumatoid arthritis (RA) [37].

References