Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Galderisi, M. et al.

Galderisi, de Simone, Cicala, De Simone, D'Errico, Caso, de Divitiis,

Coronary flow reserve in hypertensive patients with appropriate or inappropriate left ventricular mass.

OBJECTIVE: To assess the association between coronary flow reserve (CFR) and levels of left ventricular mass (LVM) exceeding the compensatory needs in arterial hypertension. DESIGN, SETTINGS AND PATIENTS: The association between the excess of LV mass and CFR was assessed in a population of 40 consecutive hypertensive outpatients free of coronary heart disease, 22 with appropriate and 17 with inappropriately high LVM (i.e. LVM exceeding 128% of the value predicted by sex, stroke work and height in m(2.7)). The CFR (the ratio between dipyridamole and basal diastolic peak velocity) of the distal left anterior descending artery was measured by transthoracic Doppler echocardiography. RESULTS: Patients with inappropriate LVM had similar age, body mass index (BMI), baseline blood pressure (BP) and coronary velocities, but lower LV systolic function, post-dipyridamole diastolic peak velocities (P < 0.05) and lower CFR (P < 0.002) than patients with appropriate LVM. CFR was negatively related to the extent of the excess of LVM (beta = -0.44, P < 0.005), independently of potential combined effect of age, BMI and post-dipyridamole diastolic BP. Impairment of CFR (i.e. < 2) was better discriminated by identification of clear-cut inappropriate LVM (P < 0.004) than by the presence of LV hypertrophy (i.e. LV mass index > or = 51 g/m(2.7); P = 0.057). CONCLUSIONS: In hypertensive patients free of coronary artery disease, the degree of reduction in CFR is associated with the excess of LVM beyond the values compensatory for individual haemodynamic load. This relation is also independent of the presence of LV hypertrophy.[1]

References

Coronary flow reserve in hypertensive patients with appropriate or inappropriate left ventricular mass. Galderisi, M., de Simone, G., Cicala, S., De Simone, L., D'Errico, A., Caso, P., de Divitiis, O. J. Hypertens. (2003) [Pubmed]

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