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Savaskan, E. et al.

Savaskan, Olivieri, Meier, Seifritz, Wirz-Justice, Müller-Spahn,

Red wine ingredient resveratrol protects from beta-amyloid neurotoxicity.

BACKGROUND: beta-Amyloid peptide (Abeta), a neutrotoxic substance, has been implicated to a great degree in cell death during the course of AD. Resveratrol, a natural polyphenol mainly found in red wine, has been shown to be cardioprotective and chemoprotective. Since a moderate wine intake correlates with a lower risk for Alzheimer disease (AD), an additional neuroprotective effect has been postulated for resveratrol. OBJECTIVE: The present study aimed at elucidating the possible neuroprotective effects of resveratrol against Abeta-induced neurotoxicity. METHODS: The neuroprotective capacity against Abeta-related oxidative stress was studied in a cell culture model suitable for studying such potentially neuroprotective substances. RESULTS: Resveratrol maintains cell viability and exerts an anti-oxidative action by enhancing the intracellular free-radical scavenger glutathione. CONCLUSION: Our findings suggest that red wine may be neuroprotective through the actions of resveratrol.[1]

References

Red wine ingredient resveratrol protects from beta-amyloid neurotoxicity. Savaskan, E., Olivieri, G., Meier, F., Seifritz, E., Wirz-Justice, A., Müller-Spahn, F. Gerontology. (2003) [Pubmed]

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