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Yoshinaga, T. et al.

Yoshinaga, Kaneko, Kinoshita, Tsukamoto, Watabe,

The molecular mechanisms of life history alterations in a rotifer: a novel approach in population dynamics.

The rotifer Brachionus plicatilis is a widely-used model for population dynamics studies. During the population growth of B. plicatilis, life history parameters such as reproduction and lifespan change widely, and determine the balance between birth and death rates that regulates the population fluctuations. The lifespan of B. plicatilis was extended 30% by inhibiting a phosphatidylinositol-3-OH kinase involved in an insulin/insulin-like growth factor (IGF) signal transduction pathway that regulates the reproduction and lifespan in nematodes. Subsequently, we cloned a cDNA encoding Mn-superoxide dismutase (SOD), which may function downstream of the IGF pathway. Real-time reverse-transcription polymerase chain reaction analysis revealed that the expression level of Mn-SOD mRNA was higher in B. plicatilis with longer lifespans than those with shorter lifespans. In addition, stress proteins may also influence population dynamics as molecules regulating lifespan and molecular chaperones to maintain the cellular integrity. Accordingly, we cloned two stress protein genes encoding HSP70 and GRP94, and found that their expression changed during the population growth of rotifers. Thus, this novel approach of integrating population ecology and molecular biology has potential use in investigation the detailed mechanisms of rotifer population dynamics.[1]

References

The molecular mechanisms of life history alterations in a rotifer: a novel approach in population dynamics. Yoshinaga, T., Kaneko, G., Kinoshita, S., Tsukamoto, K., Watabe, S. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2003) [Pubmed]

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