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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Acid-sensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration.

pH variations in the retina are thought to be involved in the fine-tuning of visual perception. We show that both photoreceptors and neurons of the mouse retina express the H+-gated cation channel subunits acid-sensing ion channel 2a (ASIC2a) and ASIC2b. Inactivation of the ASIC2 gene in mice leads to an increase in the rod electroretinogram a- and b-waves and thus to an enhanced gain of visual transduction. ASIC2 knock-out mice are also more sensitive to light-induced retinal degeneration. We suggest that ASIC2 is a negative modulator of rod phototransduction, and that functional ASIC2 channels are beneficial for the maintenance of retinal integrity.[1]

References

  1. Acid-sensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration. Ettaiche, M., Guy, N., Hofman, P., Lazdunski, M., Waldmann, R. J. Neurosci. (2004) [Pubmed]
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