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Sankaranarayanan, R. et al.

Sankaranarayanan, Rajkumar, Theresa, Esmy, Mahe, Bagyalakshmi, Thara, Frappart, Lucas, Muwonge, Shanthakumari, Jeevan, Subbarao, Parkin, Cherian,

Initial results from a randomized trial of cervical visual screening in rural south India.

The impact of a single round of screening of visual inspection with acetic acid (VIA) on cervical cancer incidence and mortality was investigated in a cluster randomized trial in south India. Women 30-59 years of age in 113 clusters in Dindigul District were randomized to VIA screening (57 clusters, 48,225 women) by nurses and to a control group (56 clusters, 30,167 women). 30,577 eligible women were screened between May 2000 and April 2003; 2,939 (9.6%) screen-positive women were investigated with colposcopy by nurses and 2,777 (9.1%) women had biopsy. CIN 1 was diagnosed in 1,778 women, CIN 2-3 lesions were found in 222, and there were 69 screen detected invasive cervical cancers. The detection rates of lesions per 1,000 screened women were 58.2 for CIN 1, 7.3 for CIN 2-3, and 2.3 for invasive cancer. The detection rate of high-grade lesions in our study was 2-3-fold higher than those observed in repeatedly screened populations in developed countries. 71% of women with CIN 1 and 80% of those with CIN 2-3 lesions accepted cryotherapy provided by nurses and surgical treatment by mid-level clinicians. Overall, 97 and 34 incident cervical cancer cases were observed in the intervention and control arms, respectively. The intervention arm accrued 124,144 person years and the control arm accrued 90,172 during the study period. The age standardized cervical cancer incidence rates were 92.4/100,000 person-years in the intervention and 43.1/100,000 in the control arms. In the screened arm, 35.0% of cases were in Stage I as opposed to none in the control arm. The preliminary findings from our study indicate that not only is a VIA-based screening programme feasible, safe and acceptable to a population in rural settings, it also results in early detection of cervical neoplasia.[1]

References

Initial results from a randomized trial of cervical visual screening in rural south India. Sankaranarayanan, R., Rajkumar, R., Theresa, R., Esmy, P.O., Mahe, C., Bagyalakshmi, K.R., Thara, S., Frappart, L., Lucas, E., Muwonge, R., Shanthakumari, S., Jeevan, D., Subbarao, T.M., Parkin, D.M., Cherian, J. Int. J. Cancer (2004) [Pubmed]

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