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MeSH Review

Developed Countries

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Disease relevance of Developed Countries


Psychiatry related information on Developed Countries


High impact information on Developed Countries

  • Although retinol in the blood might well be truly protective, this would be of little immediate value without discovery of the important external determinants of blood retinol which (in developed countries) do not include dietary retinol or beta-carotene [10].
  • In developed countries, the Golden Age of Medicine is at hand--for the patients [11].
  • Allergic diseases mediated by T helper type (Th) 2 cell immune responses are rising dramatically in most developed countries [12].
  • HBV is the primary cause of HCC in high-risk areas including China and Africa, whereas in developed countries such as the United States, HCV plays a more prominent role and is at least partially responsible for the increase in HCC incidence in this country [13].
  • Prostate cancer is one of the most common malignant diseases for which health-care intervention is sought worldwide, and in many developed countries it is the most common [14].

Chemical compound and disease context of Developed Countries


Biological context of Developed Countries


Anatomical context of Developed Countries


Associations of Developed Countries with chemical compounds


Gene context of Developed Countries

  • Prostate cancer is the most frequent cancer among men in most developed countries, yet little is known about its causes [35].
  • Studies of HLA-G and HLA-E polymorphisms in different populations from many industrialized countries have uniformly reported little sequence variation within these genes [36].
  • Hence, CB2 offers a molecular target for the diagnosis and treatment of osteoporosis, the most prevalent degenerative disease in developed countries [37].
  • RP is the most prevalent cause of registered visual handicap in those of working age in developed countries, the 50 or so mutations so far identified within the RDS-peripherin gene accounting for up to 10% of dominant cases of the disease [38].
  • Recently, there has been many investigations on the relationship between leptin and obesity, which is the main health problem in developed countries [39].

Analytical, diagnostic and therapeutic context of Developed Countries


  1. Differences in HDL cholesterol concentrations in Japanese, American, and Australian children. Dwyer, T., Iwane, H., Dean, K., Odagiri, Y., Shimomitsu, T., Blizzard, L., Srinivasan, S., Nicklas, T., Wattigney, W., Riley, M., Berenson, G. Circulation (1997) [Pubmed]
  2. Amyloidosis. Pepys, M.B. Annu. Rev. Med. (2006) [Pubmed]
  3. A novel tissue inhibitor of metalloproteinases-3 mutation reveals a common molecular phenotype in Sorsby's fundus dystrophy. Langton, K.P., McKie, N., Curtis, A., Goodship, J.A., Bond, P.M., Barker, M.D., Clarke, M. J. Biol. Chem. (2000) [Pubmed]
  4. Long-term renoprotective effect of angiotensin-converting enzyme inhibition in non-insulin-dependent diabetes mellitus. A 7-year follow-up study. Ravid, M., Lang, R., Rachmani, R., Lishner, M. Arch. Intern. Med. (1996) [Pubmed]
  5. Primary prevention of diabetes mellitus. Zimmet, P.Z. Diabetes Care (1988) [Pubmed]
  6. Serum cholesterol and coronary artery disease in populations with low cholesterol levels: the Indian paradox. Singh, R.B., Rastogi, V., Niaz, M.A., Ghosh, S., Sy, R.G., Janus, E.D. International journal of cardiology. (1998) [Pubmed]
  7. Molecular genetics of Alzheimer disease: identification of genes and gene mutations. Van Broeckhoven, C.L. Eur. Neurol. (1995) [Pubmed]
  8. Risk factors and health determinants in older Italians. Farchi, G., Brescianini, S., Maggi, S., Mariotti, S., Scafato, E., Di Carlo, A., Baldereschi, M., Inzitari, D. Aging clinical and experimental research. (2004) [Pubmed]
  9. Changes in stone composition according to age and gender of patients: a multivariate epidemiological approach. Daudon, M., Doré, J.C., Jungers, P., Lacour, B. Urol. Res. (2004) [Pubmed]
  10. Can dietary beta-carotene materially reduce human cancer rates? Peto, R., Doll, R., Buckley, J.D., Sporn, M.B. Nature (1981) [Pubmed]
  11. In developed countries, the Golden Age of Medicine is at hand--for the patients. Lundberg, G.D. JAMA (1987) [Pubmed]
  12. Suppression of allergic airway inflammation by helminth-induced regulatory T cells. Wilson, M.S., Taylor, M.D., Balic, A., Finney, C.A., Lamb, J.R., Maizels, R.M. J. Exp. Med. (2005) [Pubmed]
  13. Environmental factors and risk for hepatocellular carcinoma. Yu, M.C., Yuan, J.M. Gastroenterology (2004) [Pubmed]
  14. Early prostate cancer: clinical decision-making. Jani, A.B., Hellman, S. Lancet (2003) [Pubmed]
  15. The acute and chronic toxic effects of vitamin A. Penniston, K.L., Tanumihardjo, S.A. Am. J. Clin. Nutr. (2006) [Pubmed]
  16. Antigenicity and immunogenicity of a synthetic oligosaccharide-protein conjugate vaccine against Haemophilus influenzae type b. Fernández-Santana, V., Cardoso, F., Rodriguez, A., Carmenate, T., Peña, L., Valdés, Y., Hardy, E., Mawas, F., Heynngnezz, L., Rodríguez, M.C., Figueroa, I., Chang, J., Toledo, M.E., Musacchio, A., Hernández, I., Izquierdo, M., Cosme, K., Roy, R., Verez-Bencomo, V. Infect. Immun. (2004) [Pubmed]
  17. Emergence of antimicrobial-resistant shigellosis in Oregon. Replogle, M.L., Fleming, D.W., Cieslak, P.R. Clin. Infect. Dis. (2000) [Pubmed]
  18. Minimum requirements of n-3 and n-6 essential fatty acids for the function of the central nervous system and for the prevention of chronic disease. Okuyama, H. Proc. Soc. Exp. Biol. Med. (1992) [Pubmed]
  19. Taenia solium cysticercosis. Garcia, H.H., Del Brutto, O.H. Infect. Dis. Clin. North Am. (2000) [Pubmed]
  20. Association of the DNA repair gene XPD Asp312Asn polymorphism with p53 gene mutations in tobacco-related non-small cell lung cancer. Gao, W.M., Romkes, M., Day, R.D., Siegfried, J.M., Luketich, J.D., Mady, H.H., Melhem, M.F., Keohavong, P. Carcinogenesis (2003) [Pubmed]
  21. Hepatitis B virus, tobacco smoking and ethanol consumption in the etiology of hepatocellular carcinoma. Trichopoulos, D., Day, N.E., Kaklamani, E., Tzonou, A., Muñoz, N., Zavitsanos, X., Koumantaki, Y., Trichopoulou, A. Int. J. Cancer (1987) [Pubmed]
  22. Trifluoroacetate in ocean waters. Frank, H., Christoph, E.H., Holm-Hansen, O., Bullister, J.L. Environ. Sci. Technol. (2002) [Pubmed]
  23. Effect of tea and other dietary factors on iron absorption. Zijp, I.M., Korver, O., Tijburg, L.B. Critical reviews in food science and nutrition. (2000) [Pubmed]
  24. Cardioprotective effects of ovarian hormones and the HERS in perspective. Rosano, G.M., Graziottin, A., Fini, M. Maturitas. (2000) [Pubmed]
  25. On the genetics of retinitis pigmentosa and on mutation-independent approaches to therapeutic intervention. Farrar, G.J., Kenna, P.F., Humphries, P. EMBO J. (2002) [Pubmed]
  26. DDT and human health. Beard, J. Sci. Total Environ. (2006) [Pubmed]
  27. Arsenic, cadmium and lead levels in hair and toenail samples in pakistan. Anwar, M. Environmental sciences : an international journal of environmental physiology and toxicology. (2005) [Pubmed]
  28. Magnesium deficiency in the pathogenesis of mitral valve prolapse. Galland, L.D., Baker, S.M., McLellan, R.K. Magnesium. (1986) [Pubmed]
  29. Diagnostic accuracy of stool assays for inflammatory bacterial gastroenteritis in developed and resource-poor countries. Gill, C.J., Lau, J., Gorbach, S.L., Hamer, D.H. Clin. Infect. Dis. (2003) [Pubmed]
  30. Isolation of a human biliary glycoprotein inhibitor of cholesterol crystallization. Ohya, T., Schwarzendrube, J., Busch, N., Gresky, S., Chandler, K., Takabayashi, A., Igimi, H., Egami, K., Holzbach, R.T. Gastroenterology (1993) [Pubmed]
  31. Vitamin A supplementation during pregnancy in developed countries. Bonati, M., Nannini, S., Addis, A. Lancet (1995) [Pubmed]
  32. Natural rubber latex allergy: a problem of interdisciplinary concern in medicine. Brehler, R., Kütting, B. Arch. Intern. Med. (2001) [Pubmed]
  33. Identification and characterization of somatic steroid 5alpha-reductase (SRD5A2) mutations in human prostate cancer tissue. Makridakis, N., Akalu, A., Reichardt, J.K. Oncogene (2004) [Pubmed]
  34. The rising prevalence of diabetes and impaired glucose tolerance: the Australian Diabetes, Obesity and Lifestyle Study. Dunstan, D.W., Zimmet, P.Z., Welborn, T.A., De Courten, M.P., Cameron, A.J., Sicree, R.A., Dwyer, T., Colagiuri, S., Jolley, D., Knuiman, M., Atkins, R., Shaw, J.E. Diabetes Care (2002) [Pubmed]
  35. The complex genetic epidemiology of prostate cancer. Schaid, D.J. Hum. Mol. Genet. (2004) [Pubmed]
  36. HLA-G and HLA-E polymorphisms in an indigenous African population. The ZVITAMBO Study Group. Matte, C., Lacaille, J., Zijenah, L., Ward, B., Roger, M. Hum. Immunol. (2000) [Pubmed]
  37. Peripheral cannabinoid receptor, CB2, regulates bone mass. Ofek, O., Karsak, M., Leclerc, N., Fogel, M., Frenkel, B., Wright, K., Tam, J., Attar-Namdar, M., Kram, V., Shohami, E., Mechoulam, R., Zimmer, A., Bab, I. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  38. Murine model of autosomal dominant retinitis pigmentosa generated by targeted deletion at codon 307 of the rds-peripherin gene. McNally, N., Kenna, P.F., Rancourt, D., Ahmed, T., Stitt, A., Colledge, W.H., Lloyd, D.G., Palfi, A., O'Neill, B., Humphries, M.M., Humphries, P., Farrar, G.J. Hum. Mol. Genet. (2002) [Pubmed]
  39. The effect of adrenalectomy on leptin levels and some metabolic parameters in rats with diet-induced obesity. Yilmaz, A., Suleyman, H., Umudum, Z., Sahin, Y.N. Biol. Pharm. Bull. (2002) [Pubmed]
  40. Association of HIV-1 load and CD4 lymphocyte count with mortality among untreated African children over one year of age. Taha, T.E., Kumwenda, N.I., Hoover, D.R., Biggar, R.J., Broadhead, R.L., Cassol, S., van der Hoven, L., Markakis, D., Liomba, G.N., Chiphangwi, J.D., Miotti, P.G. AIDS (2000) [Pubmed]
  41. First-line antiretroviral therapy in Africa--how evidence-base are our recommendations? Colebunders, R., Kamya, M.R., Laurence, J., Kambugu, A., Byakwaga, H., Mwebaze, P.S., Muganga, A.M., Katwere, M., Katabira, E. AIDS reviews. (2005) [Pubmed]
  42. Where is critical care medicine in today's undergraduate medical curriculum? Qutub, H.O. Saudi medical journal. (2000) [Pubmed]
  43. Providing safe surgery for neonates in sub-Saharan Africa. Ameh, E.A., Ameh, N. Tropical doctor. (2003) [Pubmed]
  44. The effects on infants of potent antiretroviral therapy during pregnancy: a report from Spain. Bellón Cano, J.M., Sánchez-Ramón, S., Ciria, L., León, J.A., Gurbindo, D., Fortuny, C., Bertrán, J.M., Ruiz Contreras, J., Ramos, J.T., Asensi, O., Mur, A., Resino, R., Muñóz-Fernández, M.A. Med. Sci. Monit. (2004) [Pubmed]
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