The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Cryotherapy


High impact information on Cryotherapy

  • Cryotherapy failure was defined as an increasing postcryotherapy prostate-specific antigen (PSA) level of > or = 2 ng/mL above the postcryotherapy nadir, a positive prostate biopsy, or radiographic evidence of metastatic disease [6].
  • All patients received oral cryotherapy for 30 minutes with each dose of 5FU [7].
  • We now routinely recommend this cryotherapy procedure for our patients receiving daily bolus 5FU plus leucovorin [8].
  • Established ablative therapies for the treatment of primary and secondary liver tumours, including percutaneous ethanol injection, cryotherapy, and radiofrequency ablation, are discussed [9].
  • Recently, nephron-sparing surgery has emerged as a viable alternative; and experimental minimally invasive percutaneous tissue ablation techniques, including cryotherapy and radiofrequency ablation, are being evaluated [10].

Chemical compound and disease context of Cryotherapy


Biological context of Cryotherapy


Anatomical context of Cryotherapy

  • METHODS: A 10-year-old child with extensive recurrent viral papillomata involving the superior and inferior tarsal, forniceal, and bulbar conjunctiva underwent surgical excision of all diseased areas and double freeze-thaw cryotherapy [20].
  • In vivo studies have demonstrated the potential for cryotherapy to combat the process of restenosis, but the mechanisms whereby freezing and/or cooling can reduce or eliminate smooth muscle cell (SMC) proliferation and ECM synthesis are not well known [21].
  • The effect of subtenon injection of methylprednisolone acetate on the breakdown of blood retinal barrier after cryotherapy [22].
  • Endodiathermy especially could provide the typical ophthalmoscopic findings of nerve fiber bundle defects without any abnormal fluorescein angiographic findings, while endophotocoagulation and intraocular cryotherapy induced hyperfluorescence due to window defect at the coagulation site [23].
  • Although therapy with oral fluconazol and topical amphotericin B was begun, the scleritis continued to worsen, so cryotherapy and dura mater grafting were performed [24].

Associations of Cryotherapy with chemical compounds

  • RESULTS: MR imaging-guided percutaneous cryotherapy resulted in no serious complications and no clinically important changes in serum liver enzymes or creatinine or myoglobin levels [25].
  • RESULTS: Complete clearance of warts in patients who received up to six treatments of cryotherapy were observed in 86% of cases and in 70% of patients who received up to six treatments of trichloracetic acid [1].
  • METHODS: A technique was developed that combined lidocaine/prilocaine topical anesthesia with hyperfocal cryotherapy [26].
  • Eleven required cryotherapy: 5 of 25 with no dexamethasone, 5 of 9 treated for 24 days or less, and 1 of 14 treated for longer than 24 days (P < .04) [4].
  • All were treated with pharmacologic serum levels of vitamin E; 17 infants were also treated with cryotherapy (10 in one eye and 7 in both eyes) [2].

Gene context of Cryotherapy

  • One hundred fifty-two patients were enrolled in a study to evaluate 3 interferon (IFN) preparations used in combination with cryotherapy for treatment of anogenital warts [27].
  • Chemotherapy combined with laser therapy and cryotherapy has improved the ocular salvage rate for children with bilateral retinoblastoma [28].
  • CONCLUSION: Hepatic cryotherapy is effective and safe, as demonstrated by the significant reduction in postoperative CEA concentration and the low risk of complications [29].
  • In this study we aimed to assess the plasma concentrations of the cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) following hepatic cryotherapy and to relate them to the duration and volume of freezing and to hepatocellular injury [30].
  • In patients undergoing cryotherapy or resection with cryotherapy of additional lesions (n = 14), the volume and duration of hepatic freezing were significantly associated with postoperative serum AST and plasma TNF-alpha and IL-6 levels at various postoperative times [30].

Analytical, diagnostic and therapeutic context of Cryotherapy


  1. Treatment of external genital warts comparing cryotherapy (liquid nitrogen) and trichloroacetic acid. Abdullah, A.N., Walzman, M., Wade, A. Sexually transmitted diseases. (1993) [Pubmed]
  2. Severe retinopathy of prematurity in infants with birth weights less than 1250 grams: incidence and outcome of treatment with pharmacologic serum levels of vitamin E in addition to cryotherapy from 1985 to 1991. Johnson, L., Quinn, G.E., Abbasi, S., Gerdes, J., Bowen, F.W., Bhutani, V. J. Pediatr. (1995) [Pubmed]
  3. Phase I trial of edatrexate plus carboplatin in advanced solid tumors: amelioration of dose-limiting mucositis by ice chip cryotherapy. Edelman, M.J., Gandara, D.R., Perez, E.A., Lau, D., Lauder, I., Turrell, C., Uhrich, M., Meyers, F. Investigational new drugs. (1998) [Pubmed]
  4. Prolonged dexamethasone therapy reduces the incidence of cryotherapy for retinopathy of prematurity in infants of less than 1 kilogram birth weight with bronchopulmonary dysplasia. Sobel, D.B., Philip, A.G. Pediatrics (1992) [Pubmed]
  5. The emergent role of focal liver ablation techniques in the treatment of primary and secondary liver tumours. Garcea, G., Lloyd, T.D., Aylott, C., Maddern, G., Berry, D.P. Eur. J. Cancer (2003) [Pubmed]
  6. Salvage cryotherapy for recurrent prostate cancer after radiotherapy: variables affecting patient outcome. Izawa, J.I., Madsen, L.T., Scott, S.M., Tran, J.P., McGuire, E.J., Von Eschenbach, A.C., Pisters, L.L. J. Clin. Oncol. (2002) [Pubmed]
  7. Phase III controlled evaluation of sucralfate to alleviate stomatitis in patients receiving fluorouracil-based chemotherapy. Loprinzi, C.L., Ghosh, C., Camoriano, J., Sloan, J., Steen, P.D., Michalak, J.C., Schaefer, P.L., Novotny, P.J., Gerstner, J.B., White, D.F., Hatfield, A.K., Quella, S.K. J. Clin. Oncol. (1997) [Pubmed]
  8. Inhibition of fluorouracil-induced stomatitis by oral cryotherapy. Mahood, D.J., Dose, A.M., Loprinzi, C.L., Veeder, M.H., Athmann, L.M., Therneau, T.M., Sorensen, J.M., Gainey, D.K., Mailliard, J.A., Gusa, N.L. J. Clin. Oncol. (1991) [Pubmed]
  9. Ablative therapy for liver tumours. Dick, E.A., Taylor-Robinson, S.D., Thomas, H.C., Gedroyc, W.M. Gut (2002) [Pubmed]
  10. Management of small renal tumors: an overview. Reddan, D.N., Raj, G.V., Polascik, T.J. Am. J. Med. (2001) [Pubmed]
  11. The use of EMLA cream and 1% lidocaine infiltration in men for relief of pain associated with the removal of genital warts by cryotherapy. Menter, A., Black-Noller, G., Riendeau, L.A., Monti, K.L. J. Am. Acad. Dermatol. (1997) [Pubmed]
  12. Prevention of high dose L-PAM-induced mucositis by cryotherapy. Dumontet, C., Sonnet, A., Bastion, Y., Salles, G., Espinouse, D., Coiffier, B. Bone Marrow Transplant. (1994) [Pubmed]
  13. Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: A prospective, randomized study. Szeimies, R.M., Karrer, S., Radakovic-Fijan, S., Tanew, A., Calzavara-Pinton, P.G., Zane, C., Sidoroff, A., Hempel, M., Ulrich, J., Proebstle, T., Meffert, H., Mulder, M., Salomon, D., Dittmar, H.C., Bauer, J.W., Kernland, K., Braathen, L. J. Am. Acad. Dermatol. (2002) [Pubmed]
  14. Chemotherapy with focal therapy can cure intraocular retinoblastoma without radiotherapy. Gallie, B.L., Budning, A., DeBoer, G., Thiessen, J.J., Koren, G., Verjee, Z., Ling, V., Chan, H.S. Arch. Ophthalmol. (1996) [Pubmed]
  15. Surgical margin in hepatic resection for colorectal metastasis: a critical and improvable determinant of outcome. Cady, B., Jenkins, R.L., Steele, G.D., Lewis, W.D., Stone, M.D., McDermott, W.V., Jessup, J.M., Bothe, A., Lalor, P., Lovett, E.J., Lavin, P., Linehan, D.C. Ann. Surg. (1998) [Pubmed]
  16. Phase I study of percutaneous cryotherapy for colorectal liver metastasis. Huang, A., McCall, J.M., Weston, M.D., Mathur, P., Quinn, H., Henderson, D.C., Allen-Mersh, T.G. The British journal of surgery. (2002) [Pubmed]
  17. Successful cryotherapy of a benign tracheal neoplasm. Rodgers, B.M., Moazam, F., Talbert, J.L. J. Pediatr. Surg. (1988) [Pubmed]
  18. Combined use of superpulsed carbon dioxide laser and cryotherapy for treatment of facial rhytids. Nasri, S., Newman, J.P., Goode, R.L., Koch, R.J. Arch. Otolaryngol. Head Neck Surg. (1996) [Pubmed]
  19. Successful treatment of disseminated facial verrucae with contact immunotherapy. Weisshaar, E., Neumann, H.J., Gollnick, H. European journal of dermatology : EJD. (1998) [Pubmed]
  20. Autologous cultivated conjunctival transplantation for recurrent viral papillomata. Ang, L.P., Tan, D.T. Am. J. Ophthalmol. (2005) [Pubmed]
  21. In vitro model systems for evaluation of smooth muscle cell response to cryoplasty. Grassl, E.D., Bischof, J.C. Cryobiology (2005) [Pubmed]
  22. The effect of subtenon injection of methylprednisolone acetate on the breakdown of blood retinal barrier after cryotherapy. Lee, J.H., Kim, S.J., Chung, H. Korean journal of ophthalmology : KJO. (1995) [Pubmed]
  23. Ophthalmoscopic model of nerve fiber bundle defects in monkey eyes produced by intraocular retinal coagulation. Mae, Y., Matsui, M. Jpn. J. Ophthalmol. (1982) [Pubmed]
  24. Aspergillus fumigatus scleritis. Rodriguez-Ares, M.T., De Rojas Silva, M.V., Pereiro, M., Fente Sampayo, B., Gallegos Chamas, G., S-Salorio, M. Acta ophthalmologica Scandinavica. (1995) [Pubmed]
  25. MR imaging-guided percutaneous cryotherapy of liver tumors: initial experience. Silverman, S.G., Tuncali, K., Adams, D.F., vanSonnenberg, E., Zou, K.H., Kacher, D.F., Morrison, P.R., Jolesz, F.A. Radiology. (2000) [Pubmed]
  26. Hyperfocal cryotherapy of multiple Molluscum contagiosum lesions in patients with the acquired immune deficiency syndrome. Bardenstein, D.S., Elmets, C. Ophthalmology (1995) [Pubmed]
  27. A randomized, double-blind, placebo-controlled trial of systemically administered interferon-alpha, -beta, or -gamma in combination with cryotherapy for the treatment of condyloma acuminatum. Bonnez, W., Oakes, D., Bailey-Farchione, A., Choi, A., Hallahan, D., Pappas, P., Holloway, M., Corey, L., Barnum, G., Dunne, A. J. Infect. Dis. (1995) [Pubmed]
  28. Topotecan combination chemotherapy in two new rodent models of retinoblastoma. Laurie, N.A., Gray, J.K., Zhang, J., Leggas, M., Relling, M., Egorin, M., Stewart, C., Dyer, M.A. Clin. Cancer Res. (2005) [Pubmed]
  29. Cryotherapeutic ablation of liver tumours. Sheen, A.J., Poston, G.J., Sherlock, D.J. The British journal of surgery. (2002) [Pubmed]
  30. Interleukin-6 and tumor necrosis factor-alpha levels following hepatic cryotherapy: association with volume and duration of freezing. Seifert, J.K., Stewart, G.J., Hewitt, P.M., Bolton, E.J., Junginger, T., Morris, D.L. World journal of surgery. (1999) [Pubmed]
  31. Development of myopia in infants with birth weights less than 1251 grams. The Cryotherapy for Retinopathy of Prematurity Cooperative Group. Quinn, G.E., Dobson, V., Repka, M.X., Reynolds, J., Kivlin, J., Davis, B., Buckley, E., Flynn, J.T., Palmer, E.A. Ophthalmology (1992) [Pubmed]
  32. Development of new retinoblastomas after 6 cycles of chemoreduction for retinoblastoma in 162 eyes of 106 consecutive patients. Shields, C.L., Shelil, A., Cater, J., Meadows, A.T., Shields, J.A. Arch. Ophthalmol. (2003) [Pubmed]
  33. Cryotherapy of the uterine cervix. Mayeaux, E.J., Spigener, S.D., German, J.A. The Journal of family practice. (1998) [Pubmed]
  34. Transscleral iontophoresis of dexamethasone. Lam, T.T., Edward, D.P., Zhu, X.A., Tso, M.O. Arch. Ophthalmol. (1989) [Pubmed]
WikiGenes - Universities