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Crystallization and phasing of focal adhesion protein 52 from Gallus gallus.

Focal adhesion protein 52 (FAP52) is a multidomain adaptor protein of 448 amino acids characterized as an abundant component of focal adhesions. FAP52 binds to filamin via its N-terminal alpha-helical domain, suggesting a role in linking focal adhesions to the actin-based cytoskeleton. The recombinant protein was crystallized using the hanging-drop vapour-diffusion method, which yielded two crystal forms. Native data were collected from both crystal forms to 2.8 and 2.1 A resolution, respectively. For one of the crystal forms, initial MAD phasing was successfully performed using two data sets from xenon-derivatized crystals. The derivative data sets were collected using softer X-rays of 1.5 and 1.9 A wavelength. Preliminary structural analysis reveals the presence of a dimer in the asymmetric unit.[1]

References

  1. Crystallization and phasing of focal adhesion protein 52 from Gallus gallus. Töŕó, I., Nikki, M., Glumoff, T., Lehto, V.P., Djinović Carugo, K. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
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