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Gene Review

FLNA  -  filamin A, alpha

Gallus gallus

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High impact information on LOC395261

  • TW 260/240 is quite distinct from smooth muscle filamin and macrophage actin-binding protein (APB), but, in spite of its higher contour length (265 nm), seems to be related to erythrocyte spectrin (194 nm for the tetramer) [1].
  • The synthesis and deployment of filamin in chicken skeletal muscle [2].
  • By use of light microscopy and fluorescence photobleaching recovery, we have studied (a) structures that form in a system composed of copolymerized rabbit muscle actin and chicken gizzard filamin and (b) the Brownian motion of inert tracer macromolecules in this matrix [3].
  • The cytoskeleton, marked by antibodies to desmin and filamin is composed of a mainly longitudinal, meandering and branched system of fibrils that contrasts with the plait-like, interdigitating arrangement of linear fibrils of the contractile apparatus, labeled with antibodies to myosin and tropomyosin [4].
  • Membrane extracts from chicken smooth muscle contain, along with filamin, vinculin and alpha actinin, a group of polypeptides that have the ability to interact with the "barbed end" of actin filaments [5].

Biological context of LOC395261


Anatomical context of LOC395261


Associations of LOC395261 with chemical compounds


Physical interactions of LOC395261


Regulatory relationships of LOC395261

  • Villin inhibits filamin-induced F-actin gelation, but the effect can be overcome by increasing the amount of filamin [9].
  • However, a time course of agrin-induced clustering that focused on filamin revealed that most of the early AChR clusters (3-6 h) were not associated with detectable amounts of cytoskeletal material [20].
  • From these results, caldesmon and tropomyosin appeared to influence filamin binding to F-actin with different modes of actin [18].

Other interactions of LOC395261

  • Unlike other focal adhesion proteins, such as vinculin and talin, this filamin isoform is apparently not localized evenly throughout the entire area of adhesion, being absent from or greatly reduced in the distal portion of the area [21].
  • Filamin cross-links F-actin into networks that are more resilient, stiffer, more solid-like, and less dynamic than alpha-actinin and fascin [22].
  • Sedimentation assays show that villin does not inhibit gelation of actin by preventing filamin from binding to F-actin [9].
  • Reconstitution of Ca2+-sensitive gelation of actin filaments with filamin, caldesmon and calmodulin [23].
  • We determined the full cDNA sequences of chicken gizzard filamin and cgABP260 (chicken gizzard actin-binding protein 260) [24].

Analytical, diagnostic and therapeutic context of LOC395261


  1. An F-actin- and calmodulin-binding protein from isolated intestinal brush borders has a morphology related to spectrin. Glenney, J.R., Glenney, P., Osborn, M., Weber, K. Cell (1982) [Pubmed]
  2. The synthesis and deployment of filamin in chicken skeletal muscle. Gomer, R.H., Lazarides, E. Cell (1981) [Pubmed]
  3. Brownian motion of inert tracer macromolecules in polymerized and spontaneously bundled mixtures of actin and filamin. Hou, L., Luby-Phelps, K., Lanni, F. J. Cell Biol. (1990) [Pubmed]
  4. The cytoskeletal and contractile apparatus of smooth muscle: contraction bands and segmentation of the contractile elements. Draeger, A., Amos, W.B., Ikebe, M., Small, J.V. J. Cell Biol. (1990) [Pubmed]
  5. Studies on proteins that co-purify with smooth muscle vinculin: identification of immunologically related species in focal adhesions of nonmuscle and Z-lines of muscle cells. Wilkins, J.A., Risinger, M.A., Lin, S. J. Cell Biol. (1986) [Pubmed]
  6. A high molecular mass protein isolated from chicken gizzard: its localization at the dense plaques and dense bodies of smooth muscle and the Z-disks of skeletal muscle. Terasaki, A.G., Nakagawa, H., Kotani, E., Mori, H., Ohashi, K. J. Cell. Sci. (1995) [Pubmed]
  7. Purification and properties of filamin, and actin binding protein from chicken gizzard. Shizuta, Y., Shizuta, H., Gallo, M., Davies, P., Pastan, I. J. Biol. Chem. (1976) [Pubmed]
  8. Characterization of the actin binding site on smooth muscle filamin. Lebart, M.C., Méjean, C., Casanova, D., Audemard, E., Derancourt, J., Roustan, C., Benyamin, Y. J. Biol. Chem. (1994) [Pubmed]
  9. Reconstitution and regulation of actin gel-sol transformation with purified filamin and villin. Nunnally, M.H., Powell, L.D., Craig, S.W. J. Biol. Chem. (1981) [Pubmed]
  10. Actin filament cross-linking by chicken gizzard filamin is regulated by phosphorylation in vitro. Ohta, Y., Hartwig, J.H. Biochemistry (1995) [Pubmed]
  11. Localization of filamin in smooth muscle. Small, J.V., Fürst, D.O., De Mey, J. J. Cell Biol. (1986) [Pubmed]
  12. Cytoskeletal components of the vertebrate neuromuscular junction: vinculin, alpha-actinin, and filamin. Bloch, R.J., Hall, Z.W. J. Cell Biol. (1983) [Pubmed]
  13. Filamin concentration in cleavage furrow and midbody region: frequency of occurrence compared with that of alpha-actinin and myosin. Nunnally, M.H., D'Angelo, J.M., Craig, S.W. J. Cell Biol. (1980) [Pubmed]
  14. Filamin, a new high-molecular-weight protein found in smooth muscle and non-muscle cells. Wang, K., Ash, J.F., Singer, S.J. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  15. Localization of a filamin-like protein in glia of the chick central nervous system. Lemmon, V. J. Neurosci. (1986) [Pubmed]
  16. Transmembrane linkage between surface glycoproteins and components of the cytoplasm in neutrophil leukocytes. Sheterline, P., Hopkins, C.R. J. Cell Biol. (1981) [Pubmed]
  17. Cell-penetrating inhibitors of calpain block both membrane fusion and filamin cleavage in chick embryonic myoblasts. Kwak, K.B., Kambayashi, J., Kang, M.S., Ha, D.B., Chung, C.H. FEBS Lett. (1993) [Pubmed]
  18. The role of tropomyosin in the interactions of F-actin with caldesmon and actin-binding protein (or filamin). Nomura, M., Yoshikawa, K., Tanaka, T., Sobue, K., Maruyama, K. Eur. J. Biochem. (1987) [Pubmed]
  19. Crystallization and phasing of focal adhesion protein 52 from Gallus gallus. Töŕó, I., Nikki, M., Glumoff, T., Lehto, V.P., Djinović Carugo, K. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
  20. Agrin induces alpha-actinin, filamin, and vinculin to co-localize with AChR clusters on cultured chick myotubes. Shadiack, A.M., Nitkin, R.M. J. Neurobiol. (1991) [Pubmed]
  21. Identification of a filamin isoform enriched at the ends of stress fibers in chicken embryo fibroblasts. Pavalko, F.M., Otey, C.A., Burridge, K. J. Cell. Sci. (1989) [Pubmed]
  22. The bimodal role of filamin in controlling the architecture and mechanics of F-actin networks. Tseng, Y., An, K.M., Esue, O., Wirtz, D. J. Biol. Chem. (2004) [Pubmed]
  23. Reconstitution of Ca2+-sensitive gelation of actin filaments with filamin, caldesmon and calmodulin. Sobue, K., Morimoto, K., Kanda, K., Maruyama, K., Kakiuchi, S. FEBS Lett. (1982) [Pubmed]
  24. Chicken gizzard filamin, retina filamin and cgABP260 are respectively, smooth muscle-, non-muscle- and pan-muscle-type isoforms: distribution and localization in muscles. Ohashi, K., Oshima, K., Tachikawa, M., Morikawa, N., Hashimoto, Y., Ito, M., Mori, H., Kuribayashi, T., Terasaki, A.G. Cell Motil. Cytoskeleton (2005) [Pubmed]
  25. Interaction of filamin with f-actin in solution. Wang, K., Singer, S.J. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  26. A rapid purification of alpha-actinin, filamin, and a 130,000-dalton protein from smooth muscle. Feramisco, J.R., Burridge, K. J. Biol. Chem. (1980) [Pubmed]
  27. Identification of a high molecular weight actin-binding protein in skeletal muscle. Bechtel, P.J. J. Biol. Chem. (1979) [Pubmed]
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