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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Wnt inhibitory factor-1: a candidate for a new player in tumorigenesis of intestinal epithelial cells.

Using cDNA-Representational Difference Analysis it was found that expression of Opg, Ctse, Krt2-4, Fut-2, 24p3 and Wif-1 genes was elevated in intestinal adenomas as compared to normal epithelial cells of Apc(Min/+) mutant mice. Expression of Wif-1, which encodes Wnt inhibitory factor-1 was also detected in a number of tumor cell lines of epithelial cell origin including two human colon adenocarcinoma cell lines. The possible role of Wif-1 over-expression in the etiology of colorectal cancer is discussed.[1]

References

  1. Wnt inhibitory factor-1: a candidate for a new player in tumorigenesis of intestinal epithelial cells. Cebrat, M., Strzadala, L., Kisielow, P. Cancer Lett. (2004) [Pubmed]
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