Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Hughes, E.G. et al.

Hughes, Beecroft, Wilkie, Burville, Claman, Tummon, Greenblatt, Fluker, Thorpe,

A multicentre randomized controlled trial of expectant management versus IVF in women with Fallopian tube patency.

BACKGROUND: Although observational studies suggest that IVF is more effective than no treatment for women with Fallopian tube patency, this has not been tested rigorously in a randomized controlled trial (RCT). METHODS: Eligible consenting couples planning their first treatment cycle in five Canadian fertility clinics received either IVF, within 90 days of randomization, or a period of 90 days with no treatment. Random allocation was stratified by female age and sperm quality, and administered using numbered, opaque, sealed envelopes. Follow-up assessed live birth and associated morbidity. RESULTS: Sixty-eight couples were randomized to a first cycle of IVF and 71 couples had 3 months without treatment. The live birth rates were 20/68 (29%) and 1/71 (1%), respectively. The single delivery in the untreated group was of twins, as were six of the 20 IVF deliveries (30%). An average of 2.0 embryos were transferred and no triplet pregnancies resulted. The relative likelihood of delivery after allocation to IVF was 20.9-fold higher than after allocation to no treatment [95% confidence interval (CI) 2.8-155]. The presence of abnormal sperm did not reduce this likelihood. Treating four women (95% CI 3-6) with one cycle of IVF is required to achieve a single additional birth. CONCLUSIONS: This study provides a valid and up-to-date comparison for policy makers and patients as they make choices around IVF, accurately measuring and confirming a major benefit from treatment.[1]

References

A multicentre randomized controlled trial of expectant management versus IVF in women with Fallopian tube patency. Hughes, E.G., Beecroft, M.L., Wilkie, V., Burville, L., Claman, P., Tummon, I., Greenblatt, E., Fluker, M., Thorpe, K. Hum. Reprod. (2004) [Pubmed]

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