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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Random Allocation

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Disease relevance of Random Allocation


High impact information on Random Allocation

  • Precise deletion of only DPS1 and DPS2 results in random selection of donor loci and in a cells without affecting selection in alpha cells [6].
  • Labour was induced or stimulated after random allocation of the mothers to one of three oxytocics (prostaglandin E2 orally, oxytocin intravenously, or demoxytocin buccally) [7].
  • INTERVENTIONS: Random allocation to a conventional antipsychotic, haloperidol (2-20 mg/d), or an atypical antipsychotic, olanzapine (5-20 mg/d) [8].
  • INTERVENTIONS: Random allocation to daily intake of 1700 mg of calcium (calcium carbonate given in divided doses with meals); placebo; or conjugated equine estrogens (0.625 mg; days 1 to 25), progesterone (10 mg; days 16 to 25), and 1700 mg of elemental calcium daily [9].
  • Here we show, from the results of complete or partial sequence determination of a random selection of 38 tryptic peptides covering 685 residues of the subunit of PZP, that PZP and alpha 2M indeed are extensively homologous [10].

Chemical compound and disease context of Random Allocation


Biological context of Random Allocation


Anatomical context of Random Allocation


Associations of Random Allocation with chemical compounds


Gene context of Random Allocation

  • Homothallic strains of yeast containing a null allele of CHL1 exhibited almost random selection of the donor locus in a MATa background but were normal in their ability to select HMR in a MAT alpha background [27].
  • The ability of Spz1 protein to bind to the bHLH consensus-binding site, the E-box, was confirmed by EMSA, and a 9-bp asymmetric target site was identified by random selection and PCR amplification [28].
  • Defining target sequences of DNA-binding proteins by random selection and PCR: determination of the GCN4 binding sequence repertoire [29].
  • We used the method of random selection to further define the primary sequence requirements for homodimer formation and heterodimer formation with Fos [30].
  • Screening was accomplished by random selection of 250 isolated colonies from each of four enrichment cycles and reaction with PRP-treated latex beads in microtiter plates [31].

Analytical, diagnostic and therapeutic context of Random Allocation


  1. Treatment of chronic oral candidiasis with clotrimazole troches. A controlled clinical trial. Kirkpatrick, C.H., Alling, D.W. N. Engl. J. Med. (1978) [Pubmed]
  2. Adjuvant treatment of node-positive breast cancer with cyclophosphamide, doxorubicin, fluorouracil, and vincristine versus cyclophosphamide, methotrexate, and fluorouracil: final report after a 16-year median follow-up duration. Misset, J.L., di Palma, M., Delgado, M., Plagne, R., Chollet, P., Fumoleau, P., Le Mevel, B., Belpomme, D., Guerrin, J., Fargeot, P., Metz, R., Ithzaki, M., Hill, C., Mathé, G. J. Clin. Oncol. (1996) [Pubmed]
  3. Sensitivity and specificity of anti-Jo-1 antibodies in autoimmune diseases with myositis. Vázquez-Abad, D., Rothfield, N.F. Arthritis Rheum. (1996) [Pubmed]
  4. Comparative efficacy and safety of nalidixic acid versus trimethoprim/sulfamethoxazole in treatment of acute urinary tract infections in college-age women. Iravani, A., Richard, G.A., Baer, H., Fennell, R. Antimicrob. Agents Chemother. (1981) [Pubmed]
  5. Use of the P gene to genotype human metapneumovirus identifies 4 viral subtypes. Mackay, I.M., Bialasiewicz, S., Waliuzzaman, Z., Chidlow, G.R., Fegredo, D.C., Laingam, S., Adamson, P., Harnett, G.B., Rawlinson, W., Nissen, M.D., Sloots, T.P. J. Infect. Dis. (2004) [Pubmed]
  6. Alpha2p controls donor preference during mating type interconversion in yeast by inactivating a recombinational enhancer of chromosome III. Szeto, L., Fafalios, M.K., Zhong, H., Vershon, A.K., Broach, J.R. Genes Dev. (1997) [Pubmed]
  7. Neonatal jaundice after labour induced or stimulated by prostaglandin E2 or oxytocin. Lange, A.P., Secher, N.J., Westergaard, J.G., Skovgård, I. Lancet (1982) [Pubmed]
  8. Antipsychotic drug effects on brain morphology in first-episode psychosis. Lieberman, J.A., Tollefson, G.D., Charles, C., Zipursky, R., Sharma, T., Kahn, R.S., Keefe, R.S., Green, A.I., Gur, R.E., McEvoy, J., Perkins, D., Hamer, R.M., Gu, H., Tohen, M. Arch. Gen. Psychiatry (2005) [Pubmed]
  9. Calcium supplementation with and without hormone replacement therapy to prevent postmenopausal bone loss. Aloia, J.F., Vaswani, A., Yeh, J.K., Ross, P.L., Flaster, E., Dilmanian, F.A. Ann. Intern. Med. (1994) [Pubmed]
  10. Partial primary structure of human pregnancy zone protein: extensive sequence homology with human alpha 2-macroglobulin. Sottrup-Jensen, L., Folkersen, J., Kristensen, T., Tack, B.F. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  11. Pain relief after inguinal hernia repair: a randomized double-blind study. Nehra, D., Gemmell, L., Pye, J.K. The British journal of surgery. (1995) [Pubmed]
  12. Intravenous regional anesthesia with meperidine. Acalovschi, I., Cristea, T. Anesth. Analg. (1995) [Pubmed]
  13. Temperature, hematocrit, pH, and glucose 4-way ANOVA of cytochrome C oxidase redox status during systemic cold circulatory arrest in swine. Gagnon, R.E., Gagnon, F.A., Macnab, A.J., LeBlanc, J.G. Metabolic brain disease. (2005) [Pubmed]
  14. Treatment of trigeminal and thoracic zoster with idoxuridine. Wildenhoff, K.E., Esmann, V., Ipsen, J., Harving, H., Peterslund, N.A., Schønheyder, H. Scand. J. Infect. Dis. (1981) [Pubmed]
  15. Reduction of peripheral blood macrophages/monocytes in Kawasaki disease by intravenous gammaglobulin. Furukawa, S., Matsubara, T., Jujoh, K., Sasai, K., Nakachi, S., Sugawara, T., Yabuta, K., Kato, H. Eur. J. Pediatr. (1990) [Pubmed]
  16. alpha-Ketoglutarate dehydrogenase complex may be heterogeneous in quaternary structure. Wagenknecht, T., Francis, N., DeRosier, D.J. J. Mol. Biol. (1983) [Pubmed]
  17. Telomere length and telomerase activity in malignant lymphomas at diagnosis and relapse. Remes, K., Norrback, K.F., Rosenquist, R., Mehle, C., Lindh, J., Roos, G. Br. J. Cancer (2000) [Pubmed]
  18. Participation in screening for colorectal cancer based on a faecal occult blood test is improved by endorsement by the primary care practitioner. Cole, S.R., Young, G.P., Byrne, D., Guy, J.R., Morcom, J. Journal of medical screening. (2002) [Pubmed]
  19. Lercanidipine vs lacidipine in isolated systolic hypertension. Millar-Craig, M., Shaffu, B., Greenough, A., Mitchell, L., McDonald, C. Journal of human hypertension. (2003) [Pubmed]
  20. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. Bischoff-Ferrari, H.A., Willett, W.C., Wong, J.B., Giovannucci, E., Dietrich, T., Dawson-Hughes, B. JAMA (2005) [Pubmed]
  21. A histologic comparison of Hydron and zinc oxide-eugenol as endodontic filling materials in the primary teeth of dogs. Woods, R.L., Kildea, P.M., Gabriel, S.A., Freilich, L.S. Oral Surg. Oral Med. Oral Pathol. (1984) [Pubmed]
  22. Intravenous fructose treatment of acute alcohol intoxication. Effects on alcohol metabolism. Levy, R., Elo, T., Hanenson, I.B. Arch. Intern. Med. (1977) [Pubmed]
  23. Ultraviolet irradiation corrects vitamin D deficiency and suppresses secondary hyperparathyroidism in the elderly. Chel, V.G., Ooms, M.E., Popp-Snijders, C., Pavel, S., Schothorst, A.A., Meulemans, C.C., Lips, P. J. Bone Miner. Res. (1998) [Pubmed]
  24. Intravenous/oral ciprofloxacin versus ceftazidime in the treatment of serious infections. Fass, R.J., Plouffe, J.F., Russell, J.A. Am. J. Med. (1989) [Pubmed]
  25. A comparative study of polyantibiotic and iodophor ointments in prevention of vascular catheter-related infection. Maki, D.G., Band, J.D. Am. J. Med. (1981) [Pubmed]
  26. A preliminary placebo-controlled crossover trial of fludrocortisone for chronic fatigue syndrome. Peterson, P.K., Pheley, A., Schroeppel, J., Schenck, C., Marshall, P., Kind, A., Haugland, J.M., Lambrecht, L.J., Swan, S., Goldsmith, S. Arch. Intern. Med. (1998) [Pubmed]
  27. Mutations affecting donor preference during mating type interconversion in Saccharomyces cerevisiae. Weiler, K.S., Szeto, L., Broach, J.R. Genetics (1995) [Pubmed]
  28. Spz1, a novel bHLH-Zip protein, is specifically expressed in testis. Hsu, S.H., Shyu, H.W., Hsieh-Li, H.M., Li, H. Mech. Dev. (2001) [Pubmed]
  29. Defining target sequences of DNA-binding proteins by random selection and PCR: determination of the GCN4 binding sequence repertoire. Mavrothalassitis, G., Beal, G., Papas, T.S. DNA Cell Biol. (1990) [Pubmed]
  30. Dimerization of leucine zippers analyzed by random selection. Pu, W.T., Struhl, K. Nucleic Acids Res. (1993) [Pubmed]
  31. Isolation and characterization of Actinomyces viscosus mutants defective in binding salivary proline-rich proteins. Nesbitt, W.E., Beem, J.E., Leung, K.P., Clark, W.B. Infect. Immun. (1992) [Pubmed]
  32. Comparison of the use of a physiologically based pharmacokinetic model and a classical pharmacokinetic model for dioxin exposure assessments. Emond, C., Michalek, J.E., Birnbaum, L.S., DeVito, M.J. Environ. Health Perspect. (2005) [Pubmed]
  33. Propofol vs midazolam for ICU sedation : a Canadian multicenter randomized trial. Hall, R.I., Sandham, D., Cardinal, P., Tweeddale, M., Moher, D., Wang, X., Anis, A.H. Chest (2001) [Pubmed]
  34. The effect of clonidine on sevoflurane requirements for anaesthesia and hypnosis. Katoh, T., Ikeda, K. Anaesthesia. (1997) [Pubmed]
  35. Choice of local anaesthetic drug for extradural caesarean section. Comparison of 0.5% and 0.75% bupivacaine and 1.5% etidocaine. Dutton, D.A., Moir, D.D., Howie, H.B., Thorburn, J., Watson, R. British journal of anaesthesia. (1984) [Pubmed]
  36. Post-operative delirium: predictors and prognosis in elderly orthopedic patients. Williams-Russo, P., Urquhart, B.L., Sharrock, N.E., Charlson, M.E. Journal of the American Geriatrics Society. (1992) [Pubmed]
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