High leptin level is accompanied with decreased long leptin receptor transcript in histamine deficient transgenic mice.
Leptin is a multifunctional cytokine and hormone that primarily acts in the hypothalamus and plays a key role in regulation of food intake and energy expenditure. Leptin acts through its receptor (OBR), the product of db gene that activates the Jak/STAT pathway predominantly. To exert its functions, leptin interacts with histamine as well. Histamine is a downstream effector of leptin as its release, metabolism is enhanced by leptin and hypothalamic histamine reduces food intake. In a bi-directional regulatory loop histamine also influences leptin concentration by inhibiting its expression. In this study we demonstrate that histamine deficiency elevates serum leptin level and decreases full-length leptin receptor isoform with a slight increase of the short one and results in mild late onset obesity. These observation can help to elucidate further the bi-lateral interaction of leptin and histamine, and therefore provide useful data to understand the pathomechanism of obesity.[1]References
- High leptin level is accompanied with decreased long leptin receptor transcript in histamine deficient transgenic mice. Hegyi, K., Fülöp, K.A., Kovács, K.J., Falus, A., Tóth, S. Immunol. Lett. (2004) [Pubmed]
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