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Krasagakis, K. et al.

Krasagakis, Lindschau, Fimmel, Eberle, Quass, Haller, Orfanos,

Proliferation of human melanoma cells is under tight control of protein kinase C alpha.

Exponential proliferation of human melanoma cells has been associated with low levels of protein kinase C (PKC)-alpha. The aim of the present study was to investigate the functional relationship between PKC-alpha and melanoma cell proliferation. Treatment of human melanoma cells with the selective PKC inhibitor Ro-31-8220 resulted in a significant increase of cell proliferation as measured by (3)H-thymidine incorporation and a fluorometric microassay. In addition, phosphorothioate antisense-oligodeoxynucleotides (ODNs) to PKC-alpha enhanced DNA-synthesis of human melanoma cells. Furthermore, microinjection and transient transfection of melanoma cells with PKC-alpha decreased their proliferation, as shown by the reduction of nuclear staining with the proliferation marker Ki-67. The presented data demonstrate a cause-effect relationship between PKC-alpha and melanoma cell growth, whereby PKC-alpha reversely influences the rate of cell proliferation.[1]

References

Proliferation of human melanoma cells is under tight control of protein kinase C alpha. Krasagakis, K., Lindschau, C., Fimmel, S., Eberle, J., Quass, P., Haller, H., Orfanos, C.E. J. Cell. Physiol. (2004) [Pubmed]

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