Gene Review:
PRKCA - protein kinase C, alpha
Homo sapiens
Synonyms:
AAG6, PKC-A, PKC-alpha, PKCA, PRKACA, ...
Mangoura,
Sun,
Li,
Singh,
Gutmann,
Flores,
Ahmed,
Vallianatos,
Cook,
Morash,
Rosé,
Ridgway,
Byers,
Marino,
Acconcia,
Bresciani,
Weisz,
Trentalance,
Hussaini,
Trotter,
Zhao,
Abdel-Fattah,
Amos,
Xiao,
Agi,
Redpath,
Fang,
Leung,
Lopes,
Laws,
Rabinovitz,
Tsomo,
Mercurio,
Di Mari,
Mifflin,
Adegboyega,
Saada,
Powell,
- 1,25-Dihydroxyvitamin D(3) stimulates activator protein-1-dependent Caco-2 cell differentiation. Chen, A., Davis, B.H., Bissonnette, M., Scaglione-Sewell, B., Brasitus, T.A. J. Biol. Chem. (1999)
- Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation. Podar, K., Tai, Y.T., Lin, B.K., Narsimhan, R.P., Sattler, M., Kijima, T., Salgia, R., Gupta, D., Chauhan, D., Anderson, K.C. J. Biol. Chem. (2002)
- Angiotensin II activates extracellular signal regulated kinases via protein kinase C and epidermal growth factor receptor in breast cancer cells. Greco, S., Muscella, A., Elia, M.G., Salvatore, P., Storelli, C., Mazzotta, A., Manca, C., Marsigliante, S. J. Cell. Physiol. (2003)
- Ceramide regulates cellular homeostasis via diverse stress signaling pathways. Ruvolo, P.P. Leukemia (2001)
- Resveratrol antagonizes EGFR-dependent Erk1/2 activation in human androgen-independent prostate cancer cells with associated isozyme-selective PKC alpha inhibition. Stewart, J.R., O'Brian, C.A. Investigational new drugs. (2004)
- Characterization and differential distribution of the three major human protein kinase C isozymes (PKC alpha, PKC beta, and PKC gamma) of the central nervous system in normal and Alzheimer's disease brains. Clark, E.A., Leach, K.L., Trojanowski, J.Q., Lee, V.M. Lab. Invest. (1991)
- Differential regulation of mRNAs encoding protein kinase C isoenzymes in activated human B cells. Brick-Ghannam, C., Ericson, M.L., Schelle, I., Charron, D. Hum. Immunol. (1994)
- Concurrent measures of protein kinase C and phosphoinositides in lithium-treated bipolar patients and healthy individuals: a preliminary study. Soares, J.C., Chen, G., Dippold, C.S., Wells, K.F., Frank, E., Kupfer, D.J., Manji, H.K., Mallinger, A.G. Psychiatry research. (2000)
- Protein kinase C alpha activates RAF-1 by direct phosphorylation. Kolch, W., Heidecker, G., Kochs, G., Hummel, R., Vahidi, H., Mischak, H., Finkenzeller, G., Marmé, D., Rapp, U.R. Nature (1993)
- A role for MARCKS, the alpha isozyme of protein kinase C and myosin I in zymosan phagocytosis by macrophages. Allen, L.H., Aderem, A. J. Exp. Med. (1995)
- Tauroursodeoxycholate inhibits human cholangiocarcinoma growth via Ca2+-, PKC-, and MAPK-dependent pathways. Alpini, G., Kanno, N., Phinizy, J.L., Glaser, S., Francis, H., Taffetani, S., LeSage, G. Am. J. Physiol. Gastrointest. Liver Physiol. (2004)
- Protein kinase C alpha, delta, epsilon and zeta in C6 glioma cells. TPA induces translocation and down-regulation of conventional and new PKC isoforms but not atypical PKC zeta. Chen, C.C. FEBS Lett. (1993)
- Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells. Atten, M.J., Godoy-Romero, E., Attar, B.M., Milson, T., Zopel, M., Holian, O. Investigational new drugs. (2005)
- Protein kinase C isoforms and growth, differentiation and phosphatidylcholine turnover in human neuroblastoma cells. Cook, H.W., Morash, S.C., Rosé, S.D., Ridgway, N.D., Byers, D.M. Journal of lipid mediators and cell signalling. (1996)
- 12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha. Liu, B., Maher, R.J., Hannun, Y.A., Porter, A.T., Honn, K.V. J. Natl. Cancer Inst. (1994)
- Refinement of localization of the human genes for myeloperoxidase (MPO), protein kinase C, alpha polypeptide, PRKCA, and the DNA fragment D17S21 on chromosome 17q. Latos-Bielenska, A., Klett, C., Just, W., Hameister, H. Hereditas (1991)
- Novel roles of specific isoforms of protein kinase C in activation of the c-fos serum response element. Soh, J.W., Lee, E.H., Prywes, R., Weinstein, I.B. Mol. Cell. Biol. (1999)
- A protein kinase C cDNA without the regulatory domain is active after transfection in vivo in the absence of phorbol ester. Muramatsu, M., Kaibuchi, K., Arai, K. Mol. Cell. Biol. (1989)
- Distinct nongenomic signal transduction pathways controlled by 17beta-estradiol regulate DNA synthesis and cyclin D(1) gene transcription in HepG2 cells. Marino, M., Acconcia, F., Bresciani, F., Weisz, A., Trentalance, A. Mol. Biol. Cell (2002)
- Evidence that the bradykinin-induced activation of phospholipase D and of the mitogen-activated protein kinase cascade involve different protein kinase C isoforms. Clark, K.J., Murray, A.W. J. Biol. Chem. (1995)
- Heterogeneity of protein kinase C isoenzyme gene expression in human T cell lines. Protein kinase C-beta is not required for several T cell functions. Koretzky, G.A., Wahi, M., Newton, M.E., Weiss, A. J. Immunol. (1989)
- Increased expression of protein kinase Calpha, interleukin-1alpha, and RhoA guanosine 5'-triphosphatase in osteoblasts expressing the Ser252Trp fibroblast growth factor 2 receptor Apert mutation: identification by analysis of complementary DNA microarray. Lomri, A., Lemonnier, J., Delannoy, P., Marie, P.J. J. Bone Miner. Res. (2001)
- Alpha-tocopherol decreases superoxide anion release in human monocytes under hyperglycemic conditions via inhibition of protein kinase C-alpha. Venugopal, S.K., Devaraj, S., Yang, T., Jialal, I. Diabetes (2002)
- Matrix metalloproteinase-9 is differentially expressed in nonfunctioning invasive and noninvasive pituitary adenomas and increases invasion in human pituitary adenoma cell line. Hussaini, I.M., Trotter, C., Zhao, Y., Abdel-Fattah, R., Amos, S., Xiao, A., Agi, C.U., Redpath, G.T., Fang, Z., Leung, G.K., Lopes, M.B., Laws, E.R. Am. J. Pathol. (2007)
- Rapid heterologous desensitization of muscarinic and thrombin receptor-mediated phospholipase D activation. Nieto, M., Kennedy, E., Goldstein, D., Brown, J.H. Mol. Pharmacol. (1994)
- Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta. Luo, B., Prescott, S.M., Topham, M.K. J. Biol. Chem. (2003)
- Effects of apolipoprotein E (apoE) isoforms, beta-amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts. Cedazo-Mínguez, A., Wiehager, B., Winblad, B., Hüttinger, M., Cowburn, R.F. Neurochem. Int. (2001)
- Accelerated proliferation and interleukin-2 production of thymocytes by stimulation of soluble anti-CD3 monoclonal antibody in transgenic mice carrying a rabbit protein kinase C alpha. Iwamoto, T., Hagiwara, M., Hidaka, H., Isomura, T., Kioussis, D., Nakashima, I. J. Biol. Chem. (1992)
- Protein kinase C-beta II Is an apoptotic lamin kinase in polyomavirus-transformed, etoposide-treated pyF111 rat fibroblasts. Chiarini, A., Whitfield, J.F., Armato, U., Dal Pra, I. J. Biol. Chem. (2002)
- Structural aspects of the functional modules in human protein kinase-C alpha deduced from comparative analyses. Srinivasan, N., Bax, B., Blundell, T.L., Parker, P.J. Proteins (1996)
- Phosphorylation of neurofibromin by PKC is a possible molecular switch in EGF receptor signaling in neural cells. Mangoura, D., Sun, Y., Li, C., Singh, D., Gutmann, D.H., Flores, A., Ahmed, M., Vallianatos, G. Oncogene (2006)
- RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in cancer cells: implications in drug resistance. Sharma, R., Singhal, S.S., Wickramarachchi, D., Awasthi, Y.C., Awasthi, S. Int. J. Cancer (2004)
- Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C. Ritter, M., Buechler, C., Kapinsky, M., Schmitz, G. Eur. J. Immunol. (2001)
- Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase c-{alpha} and -{beta}. Devaraj, S., Venugopal, S.K., Singh, U., Jialal, I. Diabetes (2005)
- Role of protein kinase C alpha, Arf, and cytoplasmic calcium transients in phospholipase D activation by sodium fluoride in osteoblast-like cells. Bourgoin, S.G., Harbour, D., Poubelle, P.E. J. Bone Miner. Res. (1996)
- Disruption of hepatocellular tight junctions by vascular endothelial growth factor (VEGF): a novel mechanism for tumor invasion. Schmitt, M., Horbach, A., Kubitz, R., Frilling, A., Häussinger, D. J. Hepatol. (2004)
- Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes. Werlen, G., Jacinto, E., Xia, Y., Karin, M. EMBO J. (1998)
- Structural analysis of human phospholipase D1. Sung, T.C., Zhang, Y., Morris, A.J., Frohman, M.A. J. Biol. Chem. (1999)
- Increased neuronal and glial expression of protein kinase C isoforms in neocortex of transgenic Tg2576 mice with amyloid pathology. Rossner, S., Mehlhorn, G., Schliebs, R., Bigl, V. Eur. J. Neurosci. (2001)
- Expression, subcellular distribution and response to phorbol esters of protein kinase C (PKC) isozymes in drug-sensitive and multidrug-resistant KB cells evidence for altered regulation of PKC-alpha. Cloud-Heflin, B.A., McMasters, R.A., Osborn, M.T., Chambers, T.C. Eur. J. Biochem. (1996)
- IL-1alpha-induced COX-2 expression in human intestinal myofibroblasts is dependent on a PKCzeta-ROS pathway. Di Mari, J.F., Mifflin, R.C., Adegboyega, P.A., Saada, J.I., Powell, D.W. Gastroenterology (2003)
- Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. Rabinovitz, I., Tsomo, L., Mercurio, A.M. Mol. Cell. Biol. (2004)
- Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha. Blobe, G.C., Sachs, C.W., Khan, W.A., Fabbro, D., Stabel, S., Wetsel, W.C., Obeid, L.M., Fine, R.L., Hannun, Y.A. J. Biol. Chem. (1993)