Chemical Compound Review:
BIM-9 3-[3-[4-(1-methylindol-3-yl)- 2,5-dioxo...
Synonyms:
CHEMBL6291, AG-K-37651, SureCN1567017, BSPBio_001077, KBioGR_000417, ...
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- Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells. Mahon, T.M., Matthews, J.S., O'Neill, L.A. Biochem. J. (1997)
- Proliferation of human melanoma cells is under tight control of protein kinase C alpha. Krasagakis, K., Lindschau, C., Fimmel, S., Eberle, J., Quass, P., Haller, H., Orfanos, C.E. J. Cell. Physiol. (2004)
- Human adenosine A1 receptor and P2Y2-purinoceptor-mediated activation of the mitogen-activated protein kinase cascade in transfected CHO cells. Dickenson, J.M., Blank, J.L., Hill, S.J. Br. J. Pharmacol. (1998)
- Growth inhibition induced by Ro 31-8220 and calphostin C in human glioblastoma cell lines is associated with apoptosis and inhibition of CDC2 kinase. Begemann, M., Kashimawo, S.A., Lunn, R.M., Delohery, T., Choi, Y.J., Kim, S., Heitjan, D.F., Santella, R.M., Schiff, P.B., Bruce, J.N., Weinstein, I.B. Anticancer Res. (1998)
- Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway. Zugaza, J.L., Sinnett-Smith, J., Van Lint, J., Rozengurt, E. EMBO J. (1996)
- Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion. Reed, G.L., Houng, A.K., Fitzgerald, M.L. Blood (1999)
- Pertussis toxin shows distinct early signalling events in platelet-activating factor-, leukotriene B4-, and C5a-induced eosinophil homotypic aggregation in vitro and recruitment in vivo. Teixeira, M.M., Giembycz, M.A., Lindsay, M.A., Hellewell, P.G. Blood (1997)
- Intracellular pH and tyrosine phosphorylation but not calcium determine shear stress-induced nitric oxide production in native endothelial cells. Ayajiki, K., Kindermann, M., Hecker, M., Fleming, I., Busse, R. Circ. Res. (1996)
- Neurotensin induces protein kinase C-dependent protein kinase D activation and DNA synthesis in human pancreatic carcinoma cell line PANC-1. Guha, S., Rey, O., Rozengurt, E. Cancer Res. (2002)
- Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth factor-1-binding protein-3. Shen, L., Glazer, R.I. Biochem. Pharmacol. (1998)
- Tyrosine phosphorylation of a 34-kDa protein induced by cross-linking a novel glycosylphosphatidylinositol-anchored glycoprotein (GPI-80) on human neutrophils that may regulate their adherence and migration. Yu, Y., Araki, Y., Sendo, F. IUBMB Life (2000)
- Rehmannia glutinosa induces glial cell line-derived neurotrophic factor gene expression in astroglial cells via cPKC and ERK1/2 pathways independently. Yu, H., Oh-Hashi, K., Tanaka, T., Sai, A., Inoue, M., Hirata, Y., Kiuchi, K. Pharmacol. Res. (2006)
- The staurosporine analog, Ro-31-8220, induces apoptosis independently of its ability to inhibit protein kinase C. Han, Z., Pantazis, P., Lange, T.S., Wyche, J.H., Hendrickson, E.A. Cell Death Differ. (2000)
- Regulation of phospholipase D in L6 skeletal muscle myoblasts. Role of protein kinase c and relationship to protein synthesis. Thompson, M.G., Mackie, S.C., Thom, A., Palmer, R.M. J. Biol. Chem. (1997)
- Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport. Standaert, M.L., Galloway, L., Karnam, P., Bandyopadhyay, G., Moscat, J., Farese, R.V. J. Biol. Chem. (1997)
- Bombesin, vasopressin, endothelin, bradykinin, and platelet-derived growth factor rapidly activate protein kinase D through a protein kinase C-dependent signal transduction pathway. Zugaza, J.L., Waldron, R.T., Sinnett-Smith, J., Rozengurt, E. J. Biol. Chem. (1997)
- Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C. Rushworth, S.A., Chen, X.L., Mackman, N., Ogborne, R.M., O'Connell, M.A. J. Immunol. (2005)
- Lysophosphatidic acid induces threonine phosphorylation of Tiam1 in Swiss 3T3 fibroblasts via activation of protein kinase C. Fleming, I.N., Elliott, C.M., Collard, J.G., Exton, J.H. J. Biol. Chem. (1997)
- Pervanadate stimulates amylase release and protein tyrosine phosphorylation of paxillin and p125(FAK) in differentiated AR4-2J pancreatic acinar cells. Feick, P., Gilhaus, S., Schulz, I. J. Biol. Chem. (1998)
- Bryostatin 1 induces biphasic activation of protein kinase D in intact cells. Matthews, S.A., Pettit, G.R., Rozengurt, E. J. Biol. Chem. (1997)
- Activation of extracellular signal-regulated kinase 1/2 inhibits type I collagen expression by human skin fibroblasts. Reunanen, N., Foschi, M., Han, J., Kahari, V.M. J. Biol. Chem. (2000)
- CD38 ligation results in activation of the Raf-1/mitogen-activated protein kinase and the CD3-zeta/zeta-associated protein-70 signaling pathways in Jurkat T lymphocytes. Zubiaur, M., Izquierdo, M., Terhorst, C., Malavasi, F., Sancho, J. J. Immunol. (1997)
- Molecular mechanism of thromboxane A(2)-induced platelet aggregation. Essential role for p2t(ac) and alpha(2a) receptors. Paul, B.Z., Jin, J., Kunapuli, S.P. J. Biol. Chem. (1999)
- A2B adenosine and P2Y2 receptors stimulate mitogen-activated protein kinase in human embryonic kidney-293 cells. cross-talk between cyclic AMP and protein kinase c pathways. Gao, Z., Chen, T., Weber, M.J., Linden, J. J. Biol. Chem. (1999)
- Stimulation of phospholipase D by epidermal growth factor requires protein kinase C activation in Swiss 3T3 cells. Yeo, E.J., Exton, J.H. J. Biol. Chem. (1995)
- Activation of group IV cytosolic phospholipase A2 in human eosinophils by phosphoinositide 3-kinase through a mitogen-activated protein kinase-independent pathway. Myou, S., Leff, A.R., Myo, S., Boetticher, E., Meliton, A.Y., Lambertino, A.T., Liu, J., Xu, C., Munoz, N.M., Zhu, X. J. Immunol. (2003)
- Atypical lambda/iota PKC conveys 5-lipoxygenase/leukotriene B4-mediated cross-talk between phospholipase A2s regulating NF-kappa B activation in response to tumor necrosis factor-alpha and interleukin-1beta. Anthonsen, M.W., Andersen, S., Solhaug, A., Johansen, B. J. Biol. Chem. (2001)
- Interferon-gamma-induced epithelial ICAM-1 expression and monocyte adhesion. Involvement of protein kinase C-dependent c-Src tyrosine kinase activation pathway. Chang, Y.J., Holtzman, M.J., Chen, C.C. J. Biol. Chem. (2002)
- Activation of platelet-activating factor (PAF) receptor stimulates nitric oxide (NO) release via protein kinase C-alpha in HEC-1B human endometrial epithelial cell line. Dearn, S., Rahman, M., Lewis, A., Ahmed, Z., Eggo, M.C., Ahmed, A. Mol. Med. (2000)
- Effect of protein kinase C inhibitors and 2,3-butanedione monoxime on the long-term hypothermic preservation of isolated rat hearts. Fagbemi, O.S., Northover, B.J. Clin. Sci. (1996)
- Failure to activate caspase 3 in phorbol ester-resistant leukemia cells is associated with resistance to apoptotic cell death. Choi, Y.J., Park, J.W., Woo, J.H., Kim, Y.H., Lee, S.H., Lee, J.M., Kwon, T.K. Cancer Lett. (2002)
- Vasoconstriction in rat isolated mesentery and small intestine in response to various activators of protein kinase C. Northover, A.M., Northover, B.J. Agents Actions (1994)
- Evidence for protein kinase involvement in long-term postsynaptic excitation of intrinsic primary afferent neurons in the intestine. Nguyen, T.V., Stebbing, M.J., Clerc, N., Kawai, M., Harvey, J.R., Furness, J.B. Autonomic neuroscience : basic & clinical. (2004)