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Rybicki, B.A. et al.

Rybicki, Amend, Maliarik, Iannuzzi,

Photocopier exposure and risk of sarcoidosis in African-American sibs.

BACKGROUND: In a family study of sarcoidosis in African-Americans, we detected a positive association between sarcoidosis and ever working in a sales or clerical occupation. This finding, and case reports of granulomatous lung disease in patients with photocopier toner dust exposure, led us to hypothesize that sarcoidosis risk may increase as a result of photocopier exposure. METHODS: Retrospective data on photocopier use and maintenance were collected from African-American sarcoidosis cases and their first degree relatives. The study sample consisted of 181 African-American sibships where one or more members had a history of sarcoidosis (n = 540). RESULTS: Sarcoidosis was statistically significantly associated with ever using a photocopier (Odds Ratio [OR] = 1.74, 95% confidence interval [CI]: 1.23-2.46), and ever changing photocopier toner or carrying out photocopier maintenance (OR = 2.88, 95% CI 1.83-4.54). In a conditional logistic regression model that adjusted for age and sex, the OR associated with a sarcoidosis history and being in the highest tertile of photocopier exposure ranged from 1.83 to 2.19 depending on the exposure measure used. CONCLUSIONS: These results suggest that photocopier toner dust may be a previously unrecognized antigen in the pathophysiology of some patients diagnosed with sarcoidosis.[1]

References

Photocopier exposure and risk of sarcoidosis in African-American sibs. Rybicki, B.A., Amend, K.L., Maliarik, M.J., Iannuzzi, M.C. Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders. (2004) [Pubmed]

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