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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Evidence of subtle auditory deficit in a group of patients recovered from bacterial meningitis.

OBJECTIVES: Sensorineural hearing loss of greater than 30 dB hearing loss occurs in up to 30% of patients after acute bacterial meningitis. This study investigated whether postbacterial meningitic patients with no apparent clinical sensorineural hearing loss had any evidence of more subtle subclinical cochlear deficit. DESIGN: Prospective case-controlled clinical trial. SETTING: Departments of Otolaryngology in Leicester and Nottingham, England, UK. PATIENTS: Fifty-eight controls and 20 postbacterial meningitic patients aged between 18 and 38 years were screened by a questionnaire and tympanometry to exclude hearing loss attributable to other causes. All participants fell below the 90th percentile pure-tone audiometry threshold of the Lutman and Davis UK data sets. MAIN OUTCOME MEASURES: In both ears, standard (0.25-8 kHz) pure-tone audiometry, high-frequency pure-tone audiometry (10-16 kHz), and distortion product otoacoustic emissions at 2, 4, and 6 kHz were measured. RESULTS: Mean thresholds over the range of standard pure-tone audiometry (analyzed independently) for the postbacterial meningitic patients were significantly elevated at most frequencies (p < 0.05-p < 0.001) between 4 and 7 dB in both ears above control group values. There was no evidence of significant high-frequency threshold elevation (10-16 kHz). The mean iso-distortion product values at 2, 4, and 6 kHz were elevated in both ears in the meningitis group; significantly so (p < 0.05-p < 0.01) at all three frequencies in the right ear and at 4 kHz in the left. CONCLUSIONS: Postbacterial meningitic patients with hearing below the 90th percentile range had a slight but significant subclinical threshold elevation over the standard pure-tone audiometry. This may reflect a real effect of the infection at the level of the cochlea, or it may be attributable to a mild residual cognitive defect. The moderate increases in iso-distortion product values are more likely to be real and reflect an effect on outer hair cell function in response to lower stimulus intensities.[1]

References

  1. Evidence of subtle auditory deficit in a group of patients recovered from bacterial meningitis. Mulheran, M., Wiselka, M., Johnston, M.N. Otol. Neurotol. (2004) [Pubmed]
 
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