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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Rat liver lipogenesis is modulated by interleukin-15.

Interleukin-15 (IL-15) administration to rats resulted in an important decrease in carcass fat (27%) and, consequently, in white adipose tissue mass. This decrease was linked with a decreased lipogenic rate (per g of tissue) in both adipose tissue (53%) and liver (36%). The decrease in hepatic lipogenesis was associated with lower hepatic citrate levels (49%) and a reduced activity of lipogenic enzymes. The results presented here further demonstrate the involvement of IL-15 in lipid metabolism. Thus, IL-15 seems to be able to modulate de novo fatty acid synthesis, possibly by influencing citrate tissue levels, an allosteric activator of the key lipogenic enzyme acetyl-CoA carboxylase.[1]

References

  1. Rat liver lipogenesis is modulated by interleukin-15. López-Soriano, J., Carbó, N., Almendro, V., Figueras, M., Ribas, V., Busquets, S., López-Soriano, F.J., Argilés, J.M. Int. J. Mol. Med. (2004) [Pubmed]
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