The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Acaca  -  acetyl-CoA carboxylase alpha

Rattus norvegicus

Synonyms: ACC-alpha, ACC1, Acac, Acetyl-CoA carboxylase 1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Acaca


High impact information on Acaca


Chemical compound and disease context of Acaca


Biological context of Acaca


Anatomical context of Acaca


Associations of Acaca with chemical compounds


Enzymatic interactions of Acaca


Regulatory relationships of Acaca


Other interactions of Acaca


Analytical, diagnostic and therapeutic context of Acaca


  1. MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats. Atkinson, L.L., Kelly, S.E., Russell, J.C., Bar-Tana, J., Lopaschuk, G.D. Diabetes (2002) [Pubmed]
  2. Myocardial ischemia differentially regulates LKB1 and an alternate 5'-AMP-activated protein kinase kinase. Altarejos, J.Y., Taniguchi, M., Clanachan, A.S., Lopaschuk, G.D. J. Biol. Chem. (2005) [Pubmed]
  3. Glucose regulation of acetyl-CoA carboxylase in hepatoma and islet cells. Louis, N.A., Witters, L.A. J. Biol. Chem. (1992) [Pubmed]
  4. Inhibition of acetyl-CoA carboxylase isoforms by pyridoxal phosphate. Lee, W.M., Elliott, J.E., Brownsey, R.W. J. Biol. Chem. (2005) [Pubmed]
  5. The AMP-activated protein kinase is involved in the regulation of ketone body production by astrocytes. Blázquez, C., Woods, A., de Ceballos, M.L., Carling, D., Guzmán, M. J. Neurochem. (1999) [Pubmed]
  6. Insulin resistance in uremia. Characterization of lipid metabolism in freshly isolated and primary cultures of hepatocytes from chronic uremic rats. Caro, J.F., Lanza-Jacoby, S. J. Clin. Invest. (1983) [Pubmed]
  7. Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis. Mao, J., DeMayo, F.J., Li, H., Abu-Elheiga, L., Gu, Z., Shaikenov, T.E., Kordari, P., Chirala, S.S., Heird, W.C., Wakil, S.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  8. Rapid transformation of white adipocytes into fat-oxidizing machines. Orci, L., Cook, W.S., Ravazzola, M., Wang, M.Y., Park, B.H., Montesano, R., Unger, R.H. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  9. High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5'-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase. Kudo, N., Barr, A.J., Barr, R.L., Desai, S., Lopaschuk, G.D. J. Biol. Chem. (1995) [Pubmed]
  10. Plasma triglyceride levels are higher in nephrotic than in analbuminemic rats despite a similar increase in hepatic triglyceride secretion. Joles, J.A., Bijleveld, C., van Tol, A., Geelen, M.J., Koomans, H.A. Kidney Int. (1995) [Pubmed]
  11. Resistance of lung fatty acid synthesis to inhibition by dietary fat in the meal-fed rat. Clarke, S.D., Wilson, M.D., Ibnoughazala, T. J. Nutr. (1984) [Pubmed]
  12. Acetyl coenzyme A carboxylase activity in neonatal rat cardiac myocytes in culture: citrate dependence and effects of hypoxia. Wang, D., Buja, L.M., McMillin, J.B. Arch. Biochem. Biophys. (1996) [Pubmed]
  13. Modulation of the activity of insulin-dependent enzymes of lipogenesis by glucocorticoids. Diamant, S., Shafrir, E. Eur. J. Biochem. (1975) [Pubmed]
  14. Structural features of the acetyl-CoA carboxylase gene: mechanisms for the generation of mRNAs with 5' end heterogeneity. Luo, X.C., Park, K., Lopez-Casillas, F., Kim, K.H. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  15. Unique structural features and differential phosphorylation of the 280-kDa component (isozyme) of rat liver acetyl-CoA carboxylase. Winz, R., Hess, D., Aebersold, R., Brownsey, R.W. J. Biol. Chem. (1994) [Pubmed]
  16. Acetyl-CoA carboxylase mRNA species with or without inhibitory coding sequence for Ser-1200 phosphorylation. Kong, I.S., López-Casillas, F., Kim, K.H. J. Biol. Chem. (1990) [Pubmed]
  17. Heterogeneity at the 5' end of rat acetyl-coenzyme A carboxylase mRNA. Lipogenic conditions enhance synthesis of a unique mRNA in liver. López-Casillas, F., Kim, K.H. J. Biol. Chem. (1989) [Pubmed]
  18. Analysis of the biotin-binding site on acetyl-CoA carboxylase from rat. Bai, D.H., Moon, T.W., López-Casillas, F., Andrews, P.C., Kim, K.H. Eur. J. Biochem. (1989) [Pubmed]
  19. Microsomal acetyl-CoA carboxylase: evidence for association of enzyme polymer with liver microsomes. Witters, L.A., Friedman, S.A., Bacon, G.W. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  20. Dietary and hormonal regulation of the content of acetyl coenzyme A carboxylase-synthesizing polysomes in rat liver. Nakanishi, S., Tanabe, T., Horikawa, S., Numa, S. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  21. Regulation of acetyl-coA carboxylase: properties of coA activation of acetyl-coA carboxylase. Yeh, L.A., Kim, K.H. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  22. Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase. Henin, N., Vincent, M.F., Gruber, H.E., Van den Berghe, G. FASEB J. (1995) [Pubmed]
  23. Phosphorylation of different sites of acetyl CoA carboxylase by ATP-citrate lyase kinase and cyclic AMP-dependent protein kinase. Ramakrishna, S., Benjamin, W.B. Biochem. Biophys. Res. Commun. (1983) [Pubmed]
  24. Protein kinase signaling pathway triggered by cell swelling and involved in the activation of glycogen synthase and acetyl-CoA carboxylase in isolated rat hepatocytes. Krause, U., Rider, M.H., Hue, L. J. Biol. Chem. (1996) [Pubmed]
  25. Growth-hormone-prolactin interactions in the regulation of mammary and adipose-tissue acetyl-CoA carboxylase activity and gene expression in lactating rats. Barber, M.C., Travers, M.T., Finley, E., Flint, D.J., Vernon, R.G. Biochem. J. (1992) [Pubmed]
  26. Transcriptional regulation of fatty acid synthase gene and ATP citrate-lyase gene by Sp1 and Sp3 in rat hepatocytes(1). Fukuda, H., Noguchi, T., Iritani, N. FEBS Lett. (1999) [Pubmed]
  27. A modest glucokinase overexpression in the liver promotes fed expression levels of glycolytic and lipogenic enzyme genes in the fasted state without altering SREBP-1c expression. Scott, D.K., Collier, J.J., Doan, T.T., Bunnell, A.S., Daniels, M.C., Eckert, D.T., O'Doherty, R.M. Mol. Cell. Biochem. (2003) [Pubmed]
  28. Mechanism of glucagon inhibition of liver acetyl-CoA carboxylase. Interrelationship of the effects of phosphorylation, polymer-protomer transition, and citrate on enzyme activity. Swenson, T.L., Porter, J.W. J. Biol. Chem. (1985) [Pubmed]
  29. Role of hexosamine biosynthesis in glucose-mediated up-regulation of lipogenic enzyme mRNA levels: effects of glucose, glutamine, and glucosamine on glycerophosphate dehydrogenase, fatty acid synthase, and acetyl-CoA carboxylase mRNA levels. Rumberger, J.M., Wu, T., Hering, M.A., Marshall, S. J. Biol. Chem. (2003) [Pubmed]
  30. Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. Park, H., Kaushik, V.K., Constant, S., Prentki, M., Przybytkowski, E., Ruderman, N.B., Saha, A.K. J. Biol. Chem. (2002) [Pubmed]
  31. Multiple signalling pathways involved in the stimulation of fatty acid and glycogen synthesis by insulin in rat epididymal fat cells. Moule, S.K., Edgell, N.J., Welsh, G.I., Diggle, T.A., Foulstone, E.J., Heesom, K.J., Proud, C.G., Denton, R.M. Biochem. J. (1995) [Pubmed]
  32. Effects of capsaicin on lipid metabolism in rats fed a high fat diet. Kawada, T., Hagihara, K., Iwai, K. J. Nutr. (1986) [Pubmed]
  33. Glucose regulation of the acetyl-CoA carboxylase promoter PI in rat hepatocytes. O'Callaghan, B.L., Koo, S.H., Wu, Y., Freake, H.C., Towle, H.C. J. Biol. Chem. (2001) [Pubmed]
  34. Reevaluation of properties of acetyl-CoA carboxylase from rat liver. Song, C.S., Kim, K.H. J. Biol. Chem. (1981) [Pubmed]
  35. Bimodal activation of acetyl-CoA carboxylase by glutamate. Boone, A.N., Chan, A., Kulpa, J.E., Brownsey, R.W. J. Biol. Chem. (2000) [Pubmed]
WikiGenes - Universities