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Gene Review

Il15  -  interleukin 15

Rattus norvegicus

Synonyms: IL-15, Interleukin-15
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Disease relevance of Il15

  • The production of IL-15 by colon cancer cells was not associated with the infiltration of natural killer cells into the tumors [1].
  • CONCLUSIONS: These data indicate that IL-15 produced by metastatic colon carcinoma cells can induce hyperplasia in the mucosa adjacent to colon cancer, thus contributing to angiogenesis and progression of the disease [1].
  • IL-15 induced a dramatic decrease in chemotherapy-induced gastrointestinal toxicities, significant potentiation of antitumor activity, and an increased therapeutic index of FUra administered on single dose, daily x 5 and weekly x 4 schedules [2].
  • IL-15 also moderately potentiated the antitumor activity of CPT-11 in rats bearing advanced colorectal cancer [3].
  • The recent finding of abundant IL-15 in rheumatoid arthritis synovial fluids suggested a possible role for this cytokine in the pathological destruction of bone and prompted us to determine whether IL-15 stimulates osteoclast formation [4].

High impact information on Il15


Chemical compound and disease context of Il15


Biological context of Il15


Anatomical context of Il15


Associations of Il15 with chemical compounds


Regulatory relationships of Il15


Other interactions of Il15

  • We aimed in this study to investigate if IL-15 could influence cell death and/or functional impairment of rat pancreatic islets induced by in vitro exposure to a combination of cytokines (25 U/ml IL-1beta+1000 U/ml IFN-gamma+1000 U/ml TNF-alpha) [8].
  • In euthyroid state, IL-15, IL-6 and TNFalpha decreased significantly, but IL-beta and TNFalpha were significantly higher than the baseline values (P < 0.05) while IL-6 levels turned back to the baseline values [15].
  • Moreover, low IL-15 concentration (0.1 ng/ml) strongly increased the level of calcitonin receptor mRNA of mononuclear preosteoclast-like cells [4].
  • Addition of IL-2 but not IL-15 to anti-CD4-treated alloactivated T cells restored IFN-gamma protein production without leading to enhanced IFN-gamma mRNA expression [16].
  • Thus, IL-15 seems to be able to modulate de novo fatty acid synthesis, possibly by influencing citrate tissue levels, an allosteric activator of the key lipogenic enzyme acetyl-CoA carboxylase [11].

Analytical, diagnostic and therapeutic context of Il15


  1. Production of interleukin 15 by human colon cancer cells is associated with induction of mucosal hyperplasia, angiogenesis, and metastasis. Kuniyasu, H., Ohmori, H., Sasaki, T., Sasahira, T., Yoshida, K., Kitadai, Y., Fidler, I.J. Clin. Cancer Res. (2003) [Pubmed]
  2. Interleukin 15 protects against toxicity and potentiates antitumor activity of 5-fluorouracil alone and in combination with leucovorin in rats bearing colorectal cancer. Cao, S., Troutt, A.B., Rustum, Y.M. Cancer Res. (1998) [Pubmed]
  3. Interleukin 15 offers selective protection from irinotecan-induced intestinal toxicity in a preclinical animal model. Cao, S., Black, J.D., Troutt, A.B., Rustum, Y.M. Cancer Res. (1998) [Pubmed]
  4. A novel role of IL-15 in the development of osteoclasts: inability to replace its activity with IL-2. Ogata, Y., Kukita, A., Kukita, T., Komine, M., Miyahara, A., Miyazaki, S., Kohashi, O. J. Immunol. (1999) [Pubmed]
  5. Intestinal epithelial cells both express and respond to interleukin 15. Reinecker, H.C., MacDermott, R.P., Mirau, S., Dignass, A., Podolsky, D.K. Gastroenterology (1996) [Pubmed]
  6. Myocytes respond in vivo to an antibody reactive with the acetylcholine receptor by upregulating interleukin-15: an interferon-gamma activator with the potential to influence the severity and course of experimental myasthenia gravis. Stegall, T., Krolick, K.A. J. Neuroimmunol. (2001) [Pubmed]
  7. Inhibition of lymphocyte apoptosis by pancreatic stellate cells: impact of interleukin-15. Sparmann, G., Glass, A., Brock, P., Jaster, R., Koczan, D., Thiesen, H.J., Liebe, S., Emmrich, J. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  8. Effects of interleukin-15 on suppression of rat pancreatic islets in vitro induced by proinflammatory cytokines. Wallström, J., Andersson, A.K., Sandler, S. Immunol. Lett. (2003) [Pubmed]
  9. Macro- and microcirculatory effects of IL-15. Baker, C.H., Abel, F.L. Shock (1995) [Pubmed]
  10. Interleukin-15 decreases lipid intestinal absorption. Almendro, V., Carbó, N., Busquets, S., López-Soriano, J., Figueras, M., Ametller, E., Argilés, J.M., López-Soriano, F.J. Int. J. Mol. Med. (2005) [Pubmed]
  11. Rat liver lipogenesis is modulated by interleukin-15. López-Soriano, J., Carbó, N., Almendro, V., Figueras, M., Ribas, V., Busquets, S., López-Soriano, F.J., Argilés, J.M. Int. J. Mol. Med. (2004) [Pubmed]
  12. Altered expression of antiviral cytokine mRNAs associated with cyclophosphamide's enhancement of viral oncolysis. Wakimoto, H., Fulci, G., Tyminski, E., Chiocca, E.A. Gene Ther. (2004) [Pubmed]
  13. Interleukin-15 stimulates C2 skeletal myoblast differentiation. Quinn, L.S., Haugk, K.L., Damon, S.E. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  14. Myocytes respond to both interleukin-4 and interferon-gamma: cytokine responsiveness with the potential to influence the severity and course of experimental myasthenia gravis. Stegall, T., Krolick, K.A. Clin. Immunol. (2000) [Pubmed]
  15. Osteoporotic cytokines and bone metabolism on rats with induced hyperthyroidism; changes as a result of reversal to euthyroidism. Simsek, G., Karter, Y., Aydin, S., Uzun, H. The Chinese journal of physiology. (2003) [Pubmed]
  16. IFN-gamma regulation in anti-CD4 antibody-induced T cell unresponsiveness. Sawitzki, B., Kieselbach, B., Fisser, M., Meisel, C., Vogt, K., Gaestel, M., Lehmann, M., Risch, K., Grütz, G., Volk, H.D. J. Am. Soc. Nephrol. (2004) [Pubmed]
  17. Intragraft gene expression profiles by cDNA microarray in small-for-size liver grafts. Man, K., Lo, C.M., Lee, T.K., Li, X.L., Ng, I.O., Fan, S.T. Liver Transpl. (2003) [Pubmed]
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