- A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene. Toye, A.A., Moir, L., Hugill, A., Bentley, L., Quarterman, J., Mijat, V., Hough, T., Goldsworthy, M., Haynes, A., Hunter, A.J., Browne, M., Spurr, N., Cox, R.D. Diabetes (2004)