Gene Review:
Gck - glucokinase
Mus musculus
Synonyms:
GLK, Gk, Gls006, Glucokinase, HK IV, ...
- Insulin effect during embryogenesis determines fetal growth: a possible molecular link between birth weight and susceptibility to type 2 diabetes. Terauchi, Y., Kubota, N., Tamemoto, H., Sakura, H., Nagai, R., Akanuma, Y., Kimura, S., Kadowaki, T. Diabetes (2000)
- Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis. Grupe, A., Hultgren, B., Ryan, A., Ma, Y.H., Bauer, M., Stewart, T.A. Cell (1995)
- Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. Bali, D., Svetlanov, A., Lee, H.W., Fusco-DeMane, D., Leiser, M., Li, B., Barzilai, N., Surana, M., Hou, H., Fleischer, N. J. Biol. Chem. (1995)
- Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. Postic, C., Shiota, M., Niswender, K.D., Jetton, T.L., Chen, Y., Moates, J.M., Shelton, K.D., Lindner, J., Cherrington, A.D., Magnuson, M.A. J. Biol. Chem. (1999)
- Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice. Pontoglio, M., Sreenan, S., Roe, M., Pugh, W., Ostrega, D., Doyen, A., Pick, A.J., Baldwin, A., Velho, G., Froguel, P., Levisetti, M., Bonner-Weir, S., Bell, G.I., Yaniv, M., Polonsky, K.S. J. Clin. Invest. (1998)
- NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Kojima, H., Fujimiya, M., Matsumura, K., Younan, P., Imaeda, H., Maeda, M., Chan, L. Nat. Med. (2003)
- A dominant role for glucose in beta cell compensation of insulin resistance. Weir, G.C., Bonner-Weir, S. J. Clin. Invest. (2007)
- Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and age-dependent hepatosteatosis. Inoue, Y., Inoue, J., Lambert, G., Yim, S.H., Gonzalez, F.J. J. Biol. Chem. (2004)
- Systemic treatment with sympatholytic dopamine agonists improves aberrant beta-cell hyperplasia and GLUT2, glucokinase, and insulin immunoreactive levels in ob/ob mice. Jetton, T.L., Liang, Y., Cincotta, A.H. Metab. Clin. Exp. (2001)
- Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease. Terauchi, Y., Iwamoto, K., Tamemoto, H., Komeda, K., Ishii, C., Kanazawa, Y., Asanuma, N., Aizawa, T., Akanuma, Y., Yasuda, K., Kodama, T., Tobe, K., Yazaki, Y., Kadowaki, T. J. Clin. Invest. (1997)
- Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. Dentin, R., Pégorier, J.P., Benhamed, F., Foufelle, F., Ferré, P., Fauveau, V., Magnuson, M.A., Girard, J., Postic, C. J. Biol. Chem. (2004)
- Liver glucokinase gene expression is controlled by the onecut transcription factor hepatocyte nuclear factor-6. Lannoy, V.J., Decaux, J.F., Pierreux, C.E., Lemaigre, F.P., Rousseau, G.G. Diabetologia (2002)
- Regulation of beta cell glucokinase by S-nitrosylation and association with nitric oxide synthase. Rizzo, M.A., Piston, D.W. J. Cell Biol. (2003)
- Glucokinase is an integral component of the insulin granules in glucose-responsive insulin secretory cells and does not translocate during glucose stimulation. Arden, C., Harbottle, A., Baltrusch, S., Tiedge, M., Agius, L. Diabetes (2004)
- Multiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells. Shelton, K.D., Franklin, A.J., Khoor, A., Beechem, J., Magnuson, M.A. Mol. Cell. Biol. (1992)
- Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice. Sreenan, S.K., Cockburn, B.N., Baldwin, A.C., Ostrega, D.M., Levisetti, M., Grupe, A., Bell, G.I., Stewart, T.A., Roe, M.W., Polonsky, K.S. Diabetes (1998)
- Adenovirus-mediated overexpression of sterol regulatory element binding protein-1c mimics insulin effects on hepatic gene expression and glucose homeostasis in diabetic mice. Bécard, D., Hainault, I., Azzout-Marniche, D., Bertry-Coussot, L., Ferré, P., Foufelle, F. Diabetes (2001)
- A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene. Toye, A.A., Moir, L., Hugill, A., Bentley, L., Quarterman, J., Mijat, V., Hough, T., Goldsworthy, M., Haynes, A., Hunter, A.J., Browne, M., Spurr, N., Cox, R.D. Diabetes (2004)
- Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose. Terauchi, Y., Sakura, H., Yasuda, K., Iwamoto, K., Takahashi, N., Ito, K., Kasai, H., Suzuki, H., Ueda, O., Kamada, N. J. Biol. Chem. (1995)
- Inhibitory effects of streptozotocin, tumor necrosis factor-alpha, and interleukin-1beta on glucokinase activity in pancreatic islets and gene expression of GLUT2 and glucokinase. Park, C., Kim, J.R., Shim, J.K., Kang, B.S., Park, Y.G., Nam, K.S., Lee, Y.C., Kim, C.H. Arch. Biochem. Biophys. (1999)
- Characterization of glucokinase regulatory protein-deficient mice. Grimsby, J., Coffey, J.W., Dvorozniak, M.T., Magram, J., Li, G., Matschinsky, F.M., Shiota, C., Kaur, S., Magnuson, M.A., Grippo, J.F. J. Biol. Chem. (2000)
- Increasing fructose 2,6-bisphosphate overcomes hepatic insulin resistance of type 2 diabetes. Wu, C., Okar, D.A., Newgard, C.B., Lange, A.J. Am. J. Physiol. Endocrinol. Metab. (2002)
- BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Danial, N.N., Gramm, C.F., Scorrano, L., Zhang, C.Y., Krauss, S., Ranger, A.M., Datta, S.R., Greenberg, M.E., Licklider, L.J., Lowell, B.B., Gygi, S.P., Korsmeyer, S.J. Nature (2003)
- Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes. Shiota, M., Postic, C., Fujimoto, Y., Jetton, T.L., Dixon, K., Pan, D., Grimsby, J., Grippo, J.F., Magnuson, M.A., Cherrington, A.D. Diabetes (2001)
- Partial structure of the mouse glucokinase gene. Ishimura-Oka, K., Nakamuta, M., Chu, M.J., Sullivan, M., Chan, L., Oka, K. Genomics (1995)
- Establishment of liver specific glucokinase gene knockout mice: a new animal model for screening anti-diabetic drugs. Zhang, Y.L., Tan, X.H., Xiao, M.F., Li, H., Mao, Y.Q., Yang, X., Tan, H.R. Acta Pharmacol. Sin. (2004)
- A glucose sensor role for glucokinase in anterior pituitary cells. Zelent, D., Golson, M.L., Koeberlein, B., Quintens, R., van Lommel, L., Buettger, C., Weik-Collins, H., Taub, R., Grimsby, J., Schuit, F., Kaestner, K.H., Matschinsky, F.M. Diabetes (2006)
- Reversal of type 1 diabetes by engineering a glucose sensor in skeletal muscle. Mas, A., Montané, J., Anguela, X.M., Muñoz, S., Douar, A.M., Riu, E., Otaegui, P., Bosch, F. Diabetes (2006)