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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Minocycline in Huntington's disease: a pilot study.

Minocycline is a caspase inhibitor, decreases inducible nitric oxide synthase (iNOS), and has been shown to delay disease progression in the mouse model R6/2 of Huntington's disease (HD). This safety and tolerability study included 30 patients with HD who were given minocycline over a 6-month period and underwent assessments every 2 months with laboratory studies, the Abnormal Involuntary Movements Scale, the Unified Huntington's Disease Rating Scale, and the Mini-Mental State Examination. Minocycline was well tolerated during this study period and no serious adverse events were noted.[1]


  1. Minocycline in Huntington's disease: a pilot study. Thomas, M., Ashizawa, T., Jankovic, J. Mov. Disord. (2004) [Pubmed]
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