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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Hydrophobic acetal and ketal derivatives of mannopeptimycin-alpha and desmethylhexahydromannopeptimycin-alpha: semisynthetic glycopeptides with potent activity against Gram-positive bacteria.

The effect of introducing hydrophobic groups onto the disaccharide portion of the mannopeptimycins has been examined. Under acid-catalyzed conditions dimethyl acetals and ketals react on the terminal mannose of the disaccharide moiety of mannopeptimycin-alpha and the cyclohexylalanyl analogue 2. The preferentially formed monofunctionalized 4,6-acetals and -ketals display potent antibacterial activities against Gram-positive microorganisms, including MRSA, PRSP, and VRE pathogens.[1]

References

  1. Hydrophobic acetal and ketal derivatives of mannopeptimycin-alpha and desmethylhexahydromannopeptimycin-alpha: semisynthetic glycopeptides with potent activity against Gram-positive bacteria. Dushin, R.G., Wang, T.Z., Sum, P.E., He, H., Sutherland, A.G., Ashcroft, J.S., Graziani, E.I., Koehn, F.E., Bradford, P.A., Petersen, P.J., Wheless, K.L., How, D., Torres, N., Lenoy, E.B., Weiss, W.J., Lang, S.A., Projan, S.J., Shlaes, D.M., Mansour, T.S. J. Med. Chem. (2004) [Pubmed]
 
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