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Gene Review

MSMB  -  microseminoprotein, beta-

Homo sapiens

Synonyms: Beta-microseminoprotein, HPC13, IGBF, Immunoglobulin-binding factor, MSP, ...
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Disease relevance of MSMB


Psychiatry related information on MSMB

  • OBJECTIVE: To assess the reliability and validity of the Physical Self-Perception Profile (PSPP) and the Perceived Importance Profile (PIP) and to assess relationships between these scales and disease, function, and negative affect in rheumatoid arthritis (RA) patients [5].
  • CONCLUSION: The PSPP and PIP are both reliable and valid and are sensitive to significant constructs in the mental health of women with RA [5].
  • Here, Pin1 distribution in AD, and its colocalization with pThr231 tau in AD, FTDP-17 (P301L), Pick's disease (PiD), and PSP was investigated using TG-3, a monoclonal antibody to conformationally altered pThr231 tau [6].
  • We investigated the acquisition and long-term retention of new skills in patients with cortical (Alzheimer's disease, AD) and subcortical (progressive supranuclear palsy, PSP; Parkinson's disease, PD) degeneration [7].
  • The awareness of the treatment was similar in the IMD (51%) and MSP (59%) groups, but was significantly lower in the T group (37%; p less than .01) [8].

High impact information on MSMB

  • We performed two multicenter, randomized, double-blind, placebo-controlled crossover trials, one involving 42 subjects with hypokalemic periodic paralysis (HypoPP) and the other involving 31 subjects with potassium-sensitive periodic paralysis (PSPP) [9].
  • The mechanosensory afferents and interneurons are excited by sensory nerve shock, and the components of the resulting LG PSP can be similarly modulated by the same postsynaptic potential changes [10].
  • Alanine replacement of Met12 (M12A) resulted in a peptide with biological activity indistinguishable from PSP [11].
  • METHODS: Fifty-two women (mean+/-SD age 48.4+/-10.4 years) completed the PSPP, PIP, and other measurements: the core measures of European League Against Rheumatism; the Hospital Anxiety and Depression Scale; distance walked; and peak and extrapolated maximal oxygen consumption during a 10-meter shuttle walk test [5].
  • Interestingly, constitutive phosphorylation of the PSP motif was suppressed by PD98059 but not by staurosporine under conditions in which both agents inhibited mitogen-activated protein kinases [12].

Chemical compound and disease context of MSMB


Biological context of MSMB


Anatomical context of MSMB


Associations of MSMB with chemical compounds

  • The cationic peptide Substance P had no inhibitory effect in these assays, confirming the specificity of the PSP peptides [24].
  • PSP peptides directly inhibited the binding of LPS to LPS-binding protein [24].
  • To identify residues important for plasmatocyte spreading activity, we bioassayed PSP mutants in which amino acids were either replaced with alanine or deleted [25].
  • There were also significant correlations with serum creatinine, blood urea nitrogen, and PSP (r = 0.6, 0.63, and -0.62, respectively) [26].
  • The subsequent conversion of PSPP to squalene (SQ) involves an extensive rearrangement of the carbon skeleton and a NADPH-dependent reduction [27].

Regulatory relationships of MSMB


Other interactions of MSMB

  • Due to far higher abundance of MSP in prostatic fluid, it manifests large overcapacity for CRISP-3 binding [23].
  • Multivariate analysis showed that PSPBP, as well as the bound/free PSP94 ratio, were independent predictors of biochemical relapse risk adjusting for tPSA, Gleason score, and margin status [29].
  • Computer-assisted serial section reconstruction was used to visualize the complete expression domains for MSMB, SBP, and TGM4 in the mouse prostate [30].
  • Moreover, three proteins that have previously not been associated with upper airway irritation were identified: statherin, calgranulin B and IgBF [31].
  • RESULTS: A, DHEA, DHEAS, and IGF-I were significantly lower than controls in all groups, whereas T, FT, SHBG, and IGBFP-3 were lower only in groups B and C. All hormones and carriers were negatively correlated with the number of years of postmenopause; DHEA and T also showed a positive correlation with the age of onset of menopause [32].
  • The overexpression of EZH2 was associated with a decreased expression of the MSMB gene [33].

Analytical, diagnostic and therapeutic context of MSMB


  1. Assignment of the human beta-microseminoprotein gene (MSMB) to chromosome 10q11.2. Sasaki, T., Matsumoto, N., Jinno, Y., Niikawa, N., Sakai, H., Kanetake, H., Saito, Y. Cytogenet. Cell Genet. (1996) [Pubmed]
  2. Prostatic secretory protein (PSP94) expression in human female reproductive tissues, breast and in endometrial cancer cell lines. Baijal-Gupta, M., Clarke, M.W., Finkelman, M.A., McLachlin, C.M., Han, V.K. J. Endocrinol. (2000) [Pubmed]
  3. Induction of cell cycle changes and modulation of apoptogenic/anti-apoptotic and extracellular signaling regulatory protein expression by water extracts of I'm-Yunitytrade mark (PSP). Hsieh, T.C., Wu, P., Park, S., Wu, J.M. BMC complementary and alternative medicine [electronic resource]. (2006) [Pubmed]
  4. The H1c haplotype at the MAPT locus is associated with Alzheimer's disease. Myers, A.J., Kaleem, M., Marlowe, L., Pittman, A.M., Lees, A.J., Fung, H.C., Duckworth, J., Leung, D., Gibson, A., Morris, C.M., de Silva, R., Hardy, J. Hum. Mol. Genet. (2005) [Pubmed]
  5. Physical self perceptions of women with rheumatoid arthritis. Macsween, A., Brydson, G., Fox, K.R. Arthritis Rheum. (2004) [Pubmed]
  6. Pin1 colocalization with phosphorylated tau in Alzheimer's disease and other tauopathies. Ramakrishnan, P., Dickson, D.W., Davies, P. Neurobiol. Dis. (2003) [Pubmed]
  7. Deficits in long-term retention of learned motor skills in patients with cortical or subcortical degeneration. Mochizuki-Kawai, H., Kawamura, M., Hasegawa, Y., Mochizuki, S., Oeda, R., Yamanaka, K., Tagaya, H. Neuropsychologia. (2004) [Pubmed]
  8. Patient experiences during respirator treatment--reason for intermittent positive-pressure ventilation treatment and patient awareness in the intensive care unit. Bergbom-Engberg, I., Haljamäe, H. Crit. Care Med. (1989) [Pubmed]
  9. Randomized trials of dichlorphenamide in the periodic paralyses. Working Group on Periodic Paralysis. Tawil, R., McDermott, M.P., Brown, R., Shapiro, B.C., Ptacek, L.J., McManis, P.G., Dalakas, M.C., Spector, S.A., Mendell, J.R., Hahn, A.F., Griggs, R.C. Ann. Neurol. (2000) [Pubmed]
  10. Postsynaptic modulation of rectifying electrical synaptic inputs to the LG escape command neuron in crayfish. Edwards, D.H., Heitler, W.J., Leise, E.M., Fricke, R.A. J. Neurosci. (1991) [Pubmed]
  11. Specific residues in plasmatocyte-spreading peptide are required for receptor binding and functional antagonism of insect immune cells. Clark, K.D., Garczynski, S.F., Arora, A., Crim, J.W., Strand, M.R. J. Biol. Chem. (2004) [Pubmed]
  12. Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitive cells. Yamashita, H., Xu, J., Erwin, R.A., Farrar, W.L., Kirken, R.A., Rui, H. J. Biol. Chem. (1998) [Pubmed]
  13. PSP94 expression after androgen deprivation therapy: a comparative study with prostate specific antigen in benign prostate and prostate cancer. Imasato, Y., Xuan, J.W., Sakai, H., Izawa, J.I., Saito, Y., Chin, J.L., Moussa, M. J. Urol. (2000) [Pubmed]
  14. Mortality and growth performance of broilers given drinking water supplemented with chicken-specific probiotics. Timmerman, H.M., Veldman, A., van den Elsen, E., Rombouts, F.M., Beynen, A.C. Poult. Sci. (2006) [Pubmed]
  15. Performance in practice: bacteriological efficacy in patients with drug-resistant S. pneumoniae. Garau, J. Clin. Microbiol. Infect. (2004) [Pubmed]
  16. In vitro activities of new ketolide, telithromycin, and eight other macrolide antibiotics against Streptococcus pneumoniae having mefA and ermB genes that mediate macrolide resistance. Ubukata, K., Iwata, S., Sunakawa, K. J. Infect. Chemother. (2003) [Pubmed]
  17. Immune enhancement of a polysaccharides peptides isolated from Coriolus versicolor. Li, X.Y., Wang, J.F., Zhu, P.P., Liu, L., Ge, J.B., Yang, S.X. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1990) [Pubmed]
  18. Assignment of the human gene for beta-microseminoprotein (MSMB) to chromosome 10 and demonstration of related genes in other vertebrates. Ulvsbäck, M., Spurr, N.K., Lundwall, A. Genomics (1991) [Pubmed]
  19. Alternative splicing of PSP94 (prostatic secretory protein of 94 amino acids) mRNA in prostate tissue. Xuan, J.W., Chin, J.L., Guo, Y., Chambers, A.F., Finkelman, M.A., Clarke, M.W. Oncogene (1995) [Pubmed]
  20. Complete amino acid sequence of human seminal plasma beta-inhibin. Prediction of post Gln-Arg cleavage as a maturation site. Seidah, N.G., Arbatti, N.J., Rochemont, J., Sheth, A.R., Chrétien, M. FEBS Lett. (1984) [Pubmed]
  21. Human gene for beta-microseminoprotein: its promoter structure and chromosomal localization. Ochiai, Y., Inazawa, J., Ueyama, H., Ohkubo, I. J. Biochem. (1995) [Pubmed]
  22. Solution Structures of Human and Porcine beta-Microseminoprotein. Ghasriani, H., Teilum, K., Johnsson, Y., Fernlund, P., Drakenberg, T. J. Mol. Biol. (2006) [Pubmed]
  23. beta-Microseminoprotein binds CRISP-3 in human seminal plasma. Udby, L., Lundwall, A., Johnsen, A.H., Fernlund, P., Valtonen-André, C., Blom, A.M., Lilja, H., Borregaard, N., Kjeldsen, L., Bjartell, A. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  24. Design and validation of anti-inflammatory peptides from human parotid secretory protein. Geetha, C., Venkatesh, S.G., Bingle, L., Bingle, C.D., Gorr, S.U. J. Dent. Res. (2005) [Pubmed]
  25. Alanine-scanning mutagenesis of plasmatocyte spreading peptide identifies critical residues for biological activity. Clark, K.D., Volkman, B.F., Thoetkiattikul, H., King, D., Hayakawa, Y., Strand, M.R. J. Biol. Chem. (2001) [Pubmed]
  26. Relationship between insulin response to oral glucose load and creatinine clearance. Yasuda, K., Sato, T., Furuyama, T., Yashinaga, K. Diabetes (1975) [Pubmed]
  27. Recombinant squalene synthase. Synthesis of non-head-to-tail isoprenoids in the absence of NADPH. Jarstfer, M.B., Zhang, D.L., Poulter, C.D. J. Am. Chem. Soc. (2002) [Pubmed]
  28. A PSP94-derived peptide PCK3145 inhibits MMP-9 secretion and triggers CD44 cell surface shedding: implication in tumor metastasis. Annabi, B., Bouzeghrane, M., Currie, J.C., Hawkins, R., Dulude, H., Daigneault, L., Ruiz, M., Wisniewski, J., Garde, S., Rabbani, S.A., Panchal, C., Wu, J.J., Béliveau, R. Clin. Exp. Metastasis (2005) [Pubmed]
  29. Prognostic value of prostate secretory protein of 94 amino acids and its binding protein after radical prostatectomy. Reeves, J.R., Dulude, H., Panchal, C., Daigneault, L., Ramnani, D.M. Clin. Cancer Res. (2006) [Pubmed]
  30. Markers of prostate region-specific epithelial identity define anatomical locations in the mouse prostate that are molecularly similar to human prostate cancers. Thielen, J.L., Volzing, K.G., Collier, L.S., Green, L.E., Largaespada, D.A., Marker, P.C. Differentiation (2007) [Pubmed]
  31. Nasal lavage fluid and proteomics as means to identify the effects of the irritating epoxy chemical dimethylbenzylamine. Lindahl, M., Irander, K., Tagesson, C., Ståhlbom, B. Biomarkers (2004) [Pubmed]
  32. Androgens, insulin-like growth factor-I (IGF-I), and carrier proteins (SHBG, IGFBP-3) in postmenopause. Gambera, A., Scagliola, P., Falsetti, L., Sartori, E., Bianchi, U. Menopause (New York, N.Y.) (2004) [Pubmed]
  33. The gene encoding the prostatic tumor suppressor PSP94 is a target for repression by the Polycomb group protein EZH2. Beke, L., Nuytten, M., Van Eynde, A., Beullens, M., Bollen, M. Oncogene (2007) [Pubmed]
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