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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1.

Aneuploidy, resulting from chromosome missegregation during meiosis, is a major cause of human infertility and birth defects. However, its molecular basis remains incompletely understood. Here we have identified a spectrum of chromosome anomalies in embryos of zebrafish homozygous for a hypomorphic mutation in Mps1, a kinase required for the mitotic checkpoint. These aneuploidies are caused by meiotic error and result in severe developmental defects. Our results reveal Mps1 as a critical regulator of chromosome number in zebrafish, and demonstrate how slight genetic perturbation of a mitotic checkpoint factor can dramatically reduce the fidelity of chromosome segregation during vertebrate meiosis.[1]

References

  1. Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1. Poss, K.D., Nechiporuk, A., Stringer, K.F., Lee, C., Keating, M.T. Genes Dev. (2004) [Pubmed]
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