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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effects of glucose on fsr-mediated biofilm formation in Enterococcus faecalis.

Biofilm production is frequently dependent on such environmental factors as cell density and glucose concentration. The Enterococcus faecalis quorum-sensing locus (fsr) increases enterococcal virulence in multiple animal models. To date, fsr has been shown to regulate the transcription of 2 downstream protease genes. We demonstrate that the effect of fsr mutations on biofilm formation, as well as the fsr-mediated catabolite control of biofilm, is mediated via these proteases. The present study provides additional insight into the mechanisms used by E. faecalis to establish nosocomial infection.[1]

References

  1. Effects of glucose on fsr-mediated biofilm formation in Enterococcus faecalis. Pillai, S.K., Sakoulas, G., Eliopoulos, G.M., Moellering, R.C., Murray, B.E., Inouye, R.T. J. Infect. Dis. (2004) [Pubmed]
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